Comparing Sentinel Lymph Node (SLN) Biopsy With Standard Neck Dissection for Patients With Early-Stage Oral Cavity Cancer

ClinicalTrials.gov ID: NCT04333537

Public ClinicalTrials.gov record NCT04333537. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

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ClinicalTrials.gov public records Last synced May 10, 2026, 9:41 AM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Official title

Randomized Phase II/III Trial of Sentinel Lymph Node Biopsy Versus Elective Neck Dissection for Early-Stage Oral Cavity Cancer

Study identification

NCT ID: NCT04333537
Recruitment status: Recruiting
Study type: Interventional
Phase: Phase 2, Phase 3
Lead sponsor: NRG Oncology; Other
Enrollment: 686 participants

Conditions and interventions

Conditions

Interventions

Chest Radiography Procedure
Computed Tomography Procedure
Fludeoxyglucose F-18 Other
Imaging Agent Drug
Neck Dissection Procedure
Planar Imaging Procedure
Positron Emission Tomography Procedure
Questionnaire Administration Other
Sentinel Lymph Node Biopsy Procedure
Single Photon Emission Computed Tomography Procedure

Procedure · Other · Drug

Eligibility (public fields only)

Age range: 18 Years and older
Sex: All
Healthy volunteers: Healthy volunteers not accepted

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date: Sep 22, 2020
Primary completion: Apr 26, 2031
Completion: Apr 26, 2031
Last update posted: May 3, 2026

2020 – 2031

United States locations

U.S. sites: 105
U.S. states: 32
U.S. cities: 82

Facility	City	State	ZIP	Site status
University of Alabama at Birmingham Cancer Center	Birmingham	Alabama	35233	Active, not recruiting
Banner MD Anderson Cancer Center	Gilbert	Arizona	85234	Recruiting
Mayo Clinic Hospital in Arizona	Phoenix	Arizona	85054	Recruiting
Banner University Medical Center - Tucson	Tucson	Arizona	85719	Suspended
University of Arizona Cancer Center-North Campus	Tucson	Arizona	85719	Suspended
University of Arkansas for Medical Sciences	Little Rock	Arkansas	72205	Recruiting
City of Hope Comprehensive Cancer Center	Duarte	California	91010	Active, not recruiting
UC San Diego Moores Cancer Center	La Jolla	California	92093	Recruiting
Stanford Cancer Institute Palo Alto	Palo Alto	California	94304	Recruiting
University of California Davis Comprehensive Cancer Center	Sacramento	California	95817	Active, not recruiting
UC San Diego Medical Center - Hillcrest	San Diego	California	92103	Recruiting
UCSF Medical Center-Mission Bay	San Francisco	California	94158	Recruiting
Stanford Cancer Center South Bay	San Jose	California	95124	Recruiting
Yale University	New Haven	Connecticut	06520	Recruiting
Smilow Cancer Hospital Care Center-Trumbull	Trumbull	Connecticut	06611	Recruiting
UM Sylvester Comprehensive Cancer Center at Coral Gables	Coral Gables	Florida	33146	Recruiting
UM Sylvester Comprehensive Cancer Center at Deerfield Beach	Deerfield Beach	Florida	33442	Recruiting
University of Miami Miller School of Medicine-Sylvester Cancer Center	Miami	Florida	33136	Recruiting
Emory University Hospital Midtown	Atlanta	Georgia	30308	Recruiting
Emory University Hospital/Winship Cancer Institute	Atlanta	Georgia	30322	Recruiting
Northwestern University	Chicago	Illinois	60611	Recruiting
Rush MD Anderson Cancer Center	Chicago	Illinois	60612	Recruiting
Southern Illinois University School of Medicine	Springfield	Illinois	62702	Suspended
Springfield Memorial Hospital	Springfield	Illinois	62781	Suspended
Heartland Oncology and Hematology LLP	Council Bluffs	Iowa	51503	Suspended
Methodist Jennie Edmundson Hospital	Council Bluffs	Iowa	51503	Recruiting
University of Iowa/Holden Comprehensive Cancer Center	Iowa City	Iowa	52242	Recruiting
University of Kansas Cancer Center	Kansas City	Kansas	66160	Recruiting
University of Kansas Hospital-Westwood Cancer Center	Westwood	Kansas	66205	Recruiting
University of Kentucky/Markey Cancer Center	Lexington	Kentucky	40536	Recruiting
The James Graham Brown Cancer Center at University of Louisville	Louisville	Kentucky	40202	Suspended
LSU Health Sciences Center at Shreveport	Shreveport	Louisiana	71103	Suspended
Boston Medical Center	Boston	Massachusetts	02118	Suspended
University of Michigan Rogel Cancer Center	Ann Arbor	Michigan	48109	Recruiting
Wayne State University/Karmanos Cancer Institute	Detroit	Michigan	48201	Recruiting
Henry Ford Hospital	Detroit	Michigan	48202	Recruiting
Weisberg Cancer Treatment Center	Farmington Hills	Michigan	48334	Recruiting
Henry Ford Medical Center-Columbus	Novi	Michigan	48377	Recruiting
Henry Ford West Bloomfield Hospital	West Bloomfield	Michigan	48322	Recruiting
Mayo Clinic in Rochester	Rochester	Minnesota	55905	Recruiting
SSM Health Saint Louis University Hospital	St Louis	Missouri	63104	Recruiting
Nebraska Cancer Specialists/Oncology Hematology West PC - MECC	Omaha	Nebraska	68114	Recruiting
Nebraska Methodist Hospital	Omaha	Nebraska	68114	Recruiting
Oncology Associates PC	Omaha	Nebraska	68114	Suspended
Dartmouth Hitchcock Medical Center/Dartmouth Cancer Center	Lebanon	New Hampshire	03756	Recruiting
Memorial Sloan Kettering Basking Ridge	Basking Ridge	New Jersey	07920	Recruiting
Saint Barnabas Medical Center	Livingston	New Jersey	07039	Recruiting
Memorial Sloan Kettering Monmouth	Middletown	New Jersey	07748	Recruiting
Memorial Sloan Kettering Bergen	Montvale	New Jersey	07645	Recruiting
Rutgers Cancer Institute of New Jersey	New Brunswick	New Jersey	08903	Recruiting
Roswell Park Cancer Institute	Buffalo	New York	14263	Recruiting
Memorial Sloan Kettering Commack	Commack	New York	11725	Recruiting
Memorial Sloan Kettering Westchester	East White Plains	New York	10604	Recruiting
Northwell Health/Center for Advanced Medicine	Lake Success	New York	11042	Active, not recruiting
NYU Langone Hospital - Long Island	Mineola	New York	11501	Recruiting
Long Island Jewish Medical Center	New Hyde Park	New York	11040	Active, not recruiting
Laura and Isaac Perlmutter Cancer Center at NYU Langone	New York	New York	10016	Recruiting
Manhattan Eye Ear and Throat Hospital	New York	New York	10065	Active, not recruiting
Memorial Sloan Kettering Cancer Center	New York	New York	10065	Recruiting
Lenox Hill Hospital	New York	New York	10075	Active, not recruiting
Memorial Sloan Kettering Nassau	Uniondale	New York	11553	Recruiting
UNC Lineberger Comprehensive Cancer Center	Chapel Hill	North Carolina	27599	Recruiting
Sanford Broadway Medical Center	Fargo	North Dakota	58122	Suspended
Sanford Roger Maris Cancer Center	Fargo	North Dakota	58122	Suspended
Cleveland Clinic Foundation	Cleveland	Ohio	44195	Recruiting
Ohio State University Comprehensive Cancer Center	Columbus	Ohio	43210	Recruiting
University of Oklahoma Health Sciences Center	Oklahoma City	Oklahoma	73104	Recruiting
Clackamas Radiation Oncology Center	Clackamas	Oregon	97015	Recruiting
Providence Newberg Medical Center	Newberg	Oregon	97132	Suspended
Providence Portland Medical Center	Portland	Oregon	97213	Recruiting
Providence Saint Vincent Medical Center	Portland	Oregon	97225	Recruiting
Carlisle Regional Cancer Center	Carlisle	Pennsylvania	17015	Recruiting
Geisinger Medical Center	Danville	Pennsylvania	17822	Recruiting
UPMC Hillman Cancer Center Erie	Erie	Pennsylvania	16505	Recruiting
UPMC Pinnacle Cancer Center/Community Osteopathic Campus	Harrisburg	Pennsylvania	17109	Recruiting
Penn State Milton S Hershey Medical Center	Hershey	Pennsylvania	17033-0850	Recruiting
UPMC Hillman Cancer Center at Rocco And Nancy Ortenzio Cancer Pavilion	Mechanicsburg	Pennsylvania	17050	Recruiting
Thomas Jefferson University Hospital	Philadelphia	Pennsylvania	19107	Recruiting
Fox Chase Cancer Center	Philadelphia	Pennsylvania	19111	Active, not recruiting
UPMC-Magee Womens Hospital	Pittsburgh	Pennsylvania	15213	Recruiting
University of Pittsburgh Cancer Institute (UPCI)	Pittsburgh	Pennsylvania	15232	Recruiting
UPMC-Shadyside Hospital	Pittsburgh	Pennsylvania	15232	Recruiting
UPMC Memorial	York	Pennsylvania	17408	Recruiting
Medical University of South Carolina	Charleston	South Carolina	29425	Recruiting
Sanford Cancer Center Oncology Clinic	Sioux Falls	South Dakota	57104	Suspended
Avera Cancer Institute	Sioux Falls	South Dakota	57105	Recruiting
Sanford USD Medical Center - Sioux Falls	Sioux Falls	South Dakota	57117-5134	Suspended
Methodist Hospital	Memphis	Tennessee	38104	Recruiting
University of Tennessee Health Science Center	Memphis	Tennessee	38163	Recruiting
Vanderbilt University/Ingram Cancer Center	Nashville	Tennessee	37232	Recruiting
MD Anderson in The Woodlands	Conroe	Texas	77384	Recruiting
Baylor College of Medicine/Dan L Duncan Comprehensive Cancer Center	Houston	Texas	77030	Recruiting
M D Anderson Cancer Center	Houston	Texas	77030	Recruiting
Michael E DeBakey VA Medical Center	Houston	Texas	77030	Recruiting
MD Anderson West Houston	Houston	Texas	77079	Recruiting
MD Anderson League City	League City	Texas	77573	Recruiting
MD Anderson in Sugar Land	Sugar Land	Texas	77478	Recruiting
Central Vermont Medical Center/National Life Cancer Treatment	Berlin Corners	Vermont	05602	Recruiting
University of Vermont Medical Center	Burlington	Vermont	05401	Recruiting
University of Vermont and State Agricultural College	Burlington	Vermont	05405	Recruiting
Froedtert Menomonee Falls Hospital	Menomonee Falls	Wisconsin	53051	Recruiting
Medical College of Wisconsin	Milwaukee	Wisconsin	53226	Recruiting
Froedtert and MCW Moorland Reserve Health Center	New Berlin	Wisconsin	53151	Recruiting
Drexel Town Square Health Center	Oak Creek	Wisconsin	53154	Recruiting
Froedtert West Bend Hospital/Kraemer Cancer Center	West Bend	Wisconsin	53095	Recruiting

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

Non-U.S. locations

This page focuses on the U.S. directory. The official record also lists 1 non-U.S. site.

About this trial record page

What this page shows: Public field values for ClinicalTrials.gov record NCT04333537, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do: No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from: Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh: Last update posted May 3, 2026 · Synced May 10, 2026

Open the official record

The complete protocol, eligibility criteria, and contact information for NCT04333537 live on ClinicalTrials.gov.

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