Phase 2a Study of VX-147 in Adults With APOL1-mediated Focal Segmental Glomerulosclerosis
Public ClinicalTrials.gov record NCT04340362. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase 2a, Open-label, Single-arm, 2-Part Study to Evaluate the Efficacy, Safety, and Pharmacokinetics of VX-147 in Adults With APOL1-mediated Focal Segmental Glomerulosclerosis
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
This study will evaluate the efficacy, safety and pharmacokinetics (PK) of VX-147 in participants with apolipoprotein L1 (APOL1)-mediated focal segmental glomerulosclerosis (FSGS).
Study identification
- NCT ID
- NCT04340362
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 2
- Enrollment
- 16 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years to 65 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Jun 8, 2020 (Actual)
- Primary completion
- Nov 11, 2021 (Actual)
- Completion
- Dec 9, 2021 (Actual)
- Last update posted
- Sep 24, 2025
2020 – 2021
United States locations
- U.S. sites
- 33
- U.S. states
- 17
- U.S. cities
- 28
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| University of Alabama at Birmingham - The Kirklin Clinic | Birmingham | Alabama | 35294 | — |
| California Institute of Renal Research | San Diego | California | 92123 | — |
| The George Washington University Medical Faculty Associates - Kidney Disease & Hypertension | Washington D.C. | District of Columbia | 20037 | — |
| Howard University Hospital | Washington D.C. | District of Columbia | 20060 | — |
| Kidney and Hypertension Specialists of Miami | Miami | Florida | 33150 | — |
| Florida Premier Research Institute | Winter Park | Florida | 32789 | — |
| Morehouse School of Medicine, Grady Memorial Hospital | Atlanta | Georgia | 30310 | — |
| Children's Healthcare of Atlanta | Atlanta | Georgia | 30329 | — |
| Georgia Nehphrology | Lawrenceville | Georgia | 30046 | — |
| Central Georgia Kidney Specialists PC | Macon | Georgia | 31201 | — |
| Renal Associates of Baton Rouge | Baton Rouge | Louisiana | 70808 | — |
| Ochsner Medical Center - New Orleans | New Orleans | Louisiana | 70121 | — |
| Boston Medical Center | Boston | Massachusetts | 02118 | — |
| Beth Israel Deaconess Medical Center | Boston | Massachusetts | 02215 | — |
| Renal and Transplant Associates of New England, PC | Springfield | Massachusetts | 01107 | — |
| Paragon Health, PC d/b/a Nephrology Center, PC | Kalamazoo | Michigan | 49007 | — |
| Nephrology and Hypertension Associates, LTD | Tupelo | Mississippi | 38801 | — |
| St Louis Kidney Care | St Louis | Missouri | 63136 | — |
| Nevada Kidney Disease and Hypertension Centers | Las Vegas | Nevada | 89106 | — |
| SUNY Downstate | Brooklyn | New York | 11203 | — |
| Urban Family Practice | Buffalo | New York | 14201 | — |
| Icahn School of Medicine at Mount Sinai | New York | New York | 10029 | — |
| UNC Kidney Center Division of Nephrology & Hypertension | Chapel Hill | North Carolina | 27599 | — |
| Tryon Medical Partners | Charlotte | North Carolina | 28210 | — |
| Durham Nephrology Associates, PA | Durham | North Carolina | 27704 | — |
| Duke University School of Medicine - Duke Molecular Physiology Institute | Durham | North Carolina | 27710 | — |
| Temple University Hospital | Philadelphia | Pennsylvania | 19140 | — |
| Children's Hospital of Pittsburgh of UPMC | Pittsburgh | Pennsylvania | 15224 | — |
| Medical University of South Carolina | Charleston | South Carolina | 29425 | — |
| South Carolina Nephrology and Hypertension Center, Inc. | Orangeburg | South Carolina | 29118 | — |
| Vanderbilt University VU | Nashville | Tennessee | 37232 | — |
| Prolato Clinical Research Center | Houston | Texas | 77054 | — |
| Privia Medical Group | Houston | Texas | 77095 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 11 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT04340362, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Sep 24, 2025 · Synced Oct 24, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT04340362 live on ClinicalTrials.gov.