ClinicalTrials.gov record
Study to Describe the Safety, Tolerability, Immunogenicity, and Efficacy of RNA Vaccine Candidates Against COVID-19 in Healthy Individuals
ClinicalTrials.gov ID: NCT04368728
Public ClinicalTrials.gov record NCT04368728. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A PHASE 1/2/3, PLACEBO-CONTROLLED, RANDOMIZED, OBSERVER-BLIND, DOSE-FINDING STUDY TO EVALUATE THE SAFETY, TOLERABILITY, IMMUNOGENICITY, AND EFFICACY OF SARS-COV-2 RNA VACCINE CANDIDATES AGAINST COVID-19 IN HEALTHY INDIVIDUALS
Study identification
- NCT ID
- NCT04368728
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 2, Phase 3
- Lead sponsor
- BioNTech SE
- Industry
- Enrollment
- 46,969 participants
Conditions and interventions
Conditions
Interventions
- BNT162b1 Biological
- BNT162b2 Biological
- Placebo Other
- BNT162b2SA Biological
Biological · Other
Eligibility (public fields only)
- Age range
- 12 Years and older
- Sex
- All
- Healthy volunteers
- Accepts healthy volunteers
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Apr 28, 2020
- Primary completion
- Feb 9, 2023
- Completion
- Feb 9, 2023
- Last update posted
- Mar 24, 2026
2020 – 2023
United States locations
- U.S. sites
- 154
- U.S. states
- 38
- U.S. cities
- 109
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| North Alabama Research Center, LLC | Athens | Alabama | 35611 | — |
| Birmingham Clinical Research Unit | Birmingham | Alabama | 35216 | — |
| Medical Affiliated Research Center | Huntsville | Alabama | 35801 | — |
| Optimal Research, LLC | Huntsville | Alabama | 35802 | — |
| Alliance for Multispecialty Research, LLC | Mobile | Alabama | 36608 | — |
| Chinle Comprehensive Health Care Facility | Chinle | Arizona | 86503 | — |
| Johns Hopkins Center for American Indian Health | Chinle | Arizona | 86503 | — |
| HOPE Research Institute | Phoenix | Arizona | 85018 | — |
| The Pain Center of Arizona | Phoenix | Arizona | 85018 | — |
| HOPE Research Institute | Phoenix | Arizona | 85023 | — |
| Alliance for Multispecialty Research, LLC | Tempe | Arizona | 85281 | — |
| Johns Hopkins Center for American Indian Health | Whiteriver | Arizona | 85941 | — |
| Whiteriver Indian Hospital - Garrett Building | Whiteriver | Arizona | 85941 | — |
| Whiteriver Indian Hospital | Whiteriver | Arizona | 85941 | — |
| Anaheim Clinical Trials, LLC | Anaheim | California | 92801 | — |
| Collaborative Neuroscience Research, LLC. - Investigator Site File Location | Garden Grove | California | 92845 | — |
| Collaborative Neuroscience Research, LLC | Long Beach | California | 90806 | — |
| Long Beach Clinical Trials Services Inc. | Long Beach | California | 90806 | — |
| Kaiser Permanente Los Angeles Medical Center | Los Angeles | California | 90027 | — |
| National Research Institute | Los Angeles | California | 90057 | — |
| Velocity Clinical Research, North Hollywood | North Hollywood | California | 91606 | — |
| Paradigm Clinical Research Center | Redding | California | 96001 | — |
| Kaiser Permanente Sacramento | Sacramento | California | 95815 | — |
| Clinical and Translational Science Center (CTSC) Clinical Research Center (CCRC) | Sacramento | California | 95817 | — |
| University of California Davis Health | Sacramento | California | 95817 | — |
| California Research Foundation | San Diego | California | 92123 | — |
| Kaiser Permanente Santa Clara | Santa Clara | California | 95051 | — |
| Bayview Research Group | Valley Village | California | 91607 | — |
| Diablo Clinical Research, Inc. | Walnut Creek | California | 94598 | — |
| Lynn Institute of Denver | Aurora | Colorado | 80012 | — |
| Clinical Research Consulting, LLC | Milford | Connecticut | 06460 | — |
| Yale University | New Haven | Connecticut | 06510 | — |
| Yale Center for Clinical Investigations (CSRU) | New Haven | Connecticut | 06519 | — |
| Alliance for Multispecialty Research | Coral Gables | Florida | 33134 | — |
| DeLand Clinical Research Unit | DeLand | Florida | 32720 | — |
| Fleming Island Center for Clinical Research | Fleming Island | Florida | 32003 | — |
| Indago Research & Health Center, Inc | Hialeah | Florida | 33012 | — |
| Research Centers of America | Hollywood | Florida | 33024 | — |
| Jacksonville Center for Clinical Research | Jacksonville | Florida | 32216 | — |
| Clinical Neuroscience Solutions, Inc. | Jacksonville | Florida | 32256 | — |
| Acevedo Clinical Research Associates | Miami | Florida | 33142 | — |
| Clinical Neuroscience Solutions, Inc. dba CNS Healthcare | Orlando | Florida | 32801 | — |
| Atlanta Center for Medical Research | Atlanta | Georgia | 30331 | — |
| IACT Health | Columbus | Georgia | 31904 | — |
| Meridian Clinical Research | Savannah | Georgia | 31406 | — |
| Velocity Clinical Research, Washington DC | Savannah | Georgia | 31406 | — |
| Clinical Research Atlanta | Stockbridge | Georgia | 30281 | — |
| East-West Medical Research Institute | Honolulu | Hawaii | 96814 | — |
| Solaris Clinical Research | Meridian | Idaho | 83646 | — |
| Optimal Research | Peoria | Illinois | 61614 | — |
| University of Iowa Hospitals & Clinics Investigational Drug Servces | Iowa City | Iowa | 42242 | — |
| University of Iowa Hospitals & Clinics | Iowa City | Iowa | 52242 | — |
| Velocity Clinical Research, Norfolk | Sioux City | Iowa | 51106 | — |
| Alliance for Multispecialty Research, LLC | Newton | Kansas | 67114 | — |
| Alliance for Multispecialty Research, LLC | Wichita | Kansas | 67207 | — |
| Kentucky Pediatric/ Adult Research | Bardstown | Kentucky | 40004 | — |
| Benchmark Research | Metairie | Louisiana | 70006 | — |
| Ochsner Clinic Foundation | New Orleans | Louisiana | 70121 | — |
| LSU Health Sciences Center at Shreveport Clinical Trials Office | Shreveport | Louisiana | 71101 | — |
| LSUHSC-Shreveport | Shreveport | Louisiana | 71103 | — |
| Pharmaron CPC, Inc. | Baltimore | Maryland | 21201 | — |
| University of Maryland Medical Center Investigational Drug Service Pharmacy | Baltimore | Maryland | 21201 | — |
| University of Maryland, Baltimore, Health Sciences Research Facility III | Baltimore | Maryland | 21201 | — |
| University of Maryland, Center for Vaccine Development and Global Health | Baltimore | Maryland | 21201 | — |
| Johns Hopkins Bayview Medical Center | Baltimore | Maryland | 21224 | — |
| Boston Medical Center | Boston | Massachusetts | 02118 | — |
| UMass Memorial Medical Center - University Campus | Worcester | Massachusetts | 01655 | — |
| Michigan Center for Medical Research | Farmington Hills | Michigan | 48334 | — |
| MedPharmics, LLC | Gulfport | Mississippi | 39503 | — |
| Clinical Research Professionals | Chesterfield | Missouri | 63005 | — |
| Sundance Clinical Research, LLC | St Louis | Missouri | 63141 | — |
| Bozeman Health Deaconess Hospital dba Bozeman Health Clinical Research | Bozeman | Montana | 59715 | — |
| Bozeman Health Deaconess Hospital | Bozeman | Montana | 59715 | — |
| Methodist Physicians Clinic / CCT Research | Fremont | Nebraska | 68025 | — |
| Velocity Clinical Research, Norfolk | Norfolk | Nebraska | 68701 | — |
| Quality Clinical Research, Inc. | Omaha | Nebraska | 68114 | — |
| Meridian Clinical Research, LLC | Omaha | Nebraska | 68134 | — |
| Wake Research-Clinical Research Center of Nevada, LLC | Las Vegas | Nevada | 89106 | — |
| Amici Clinical Research | Raritan | New Jersey | 08869 | — |
| South Jersey Infectious Disease | Somers Point | New Jersey | 08244 | — |
| Gallup Indian Medical Center | Gallup | New Mexico | 87301 | — |
| Johns Hopkins Center for American Indian Health | Gallup | New Mexico | 87301 | — |
| Johns Hopkins Center for American Indian Health | Shiprock | New Mexico | 87420 | — |
| Northern Navajo Medical Center | Shiprock | New Mexico | 87420 | — |
| Meridian Clinical Research, LLC | Binghamton | New York | 13901 | — |
| Meridian Clinical Research LLC | Binghamton | New York | 13905 | — |
| NYU Langone Health | New York | New York | 10016 | — |
| Icahn School of Medicine at Mount Sinai - Investigational Drug Service | New York | New York | 10029 | — |
| Icahn School of Medicine at Mount Sinai | New York | New York | 10029 | — |
| Rochester Clinical Research, Inc. | Rochester | New York | 14609 | — |
| University of Rochester Medical Center- Kari Steinmetz | Rochester | New York | 14642 | — |
| University of Rochester Medical Center | Rochester | New York | 14642 | — |
| SUNY Upstate Medical University Global Health Research Unit | Syracuse | New York | 13215 | — |
| Meridian Clinical Research LLC | Vestal | New York | 13850 | — |
| PMG Research of Raleigh, LLC d/b/a PMG Research of Cary | Cary | North Carolina | 27518 | — |
| PMG Research of Charlotte LLC | Charlotte | North Carolina | 28209 | — |
| Duke University - Main Hospital and Clinics | Durham | North Carolina | 27703 | — |
| PharmQuest | Greensboro | North Carolina | 27408 | — |
| PMG Research of Hickory, LLC | Hickory | North Carolina | 28601 | — |
| PMG Research of Raleigh, LLC | Raleigh | North Carolina | 27609 | — |
| M3 Wake Research, Inc. | Raleigh | North Carolina | 27612 | — |
| PMG Research of Salisbury, LLC | Salisbury | North Carolina | 28144 | — |
| PMG Research of Wilmington, LLC | Wilmington | North Carolina | 28401 | — |
| PMG Research of Winston-Salem, LLC | Winston-Salem | North Carolina | 27103 | — |
| Lillestol Research Llc | Fargo | North Dakota | 58104 | — |
| Meridian Clinical Research, LLC | Cincinnati | Ohio | 45219 | — |
| Cincinnati Children's Hospital Medical Center | Cincinnati | Ohio | 45229 | — |
| Meridian Clinical Research LLC | Cincinnati | Ohio | 45246 | — |
| University Hospitals Cleveland Medical Center | Cleveland | Ohio | 44106 | — |
| VA Northeast Ohio Healthcare System | Cleveland | Ohio | 44106 | — |
| Velocity Clinical Research, Inc. | Cleveland | Ohio | 44122 | — |
| Aventiv Research Inc. | Columbus | Ohio | 43213 | — |
| Dayton Clinical Research | Dayton | Ohio | 45406 | — |
| Dayton Clinical Research | Dayton | Ohio | 45409 | — |
| PriMED Clinical Research | Dayton | Ohio | 45429 | — |
| Senders Pediatrics | South Euclid | Ohio | 44121 | — |
| Lynn Institute of Norman | Norman | Oklahoma | 73072 | — |
| Kaiser Permanente Northwest-Center for Health Research | Portland | Oregon | 97227 | — |
| Lehigh Valley Health Network/Network Office of Research and Innovation | Allentown | Pennsylvania | 18102 | — |
| Velocity Clinical Research, Providence | East Greenwich | Rhode Island | 02818 | — |
| Main Street Physician's Care | Little River | South Carolina | 29566 | — |
| Main Street Physician's Care | Loris | South Carolina | 29569 | — |
| Holston Medical Group-Clinical Research | Bristol | Tennessee | 37620 | — |
| Holston Medical Group | Kingsport | Tennessee | 37660 | — |
| Alliance for Multispecialty Research, LLC | Knoxville | Tennessee | 37909 | — |
| Alliance for Multispecialty Research, LLC | Knoxville | Tennessee | 37920 | — |
| Clinical Neuroscience Solutions, Inc. | Memphis | Tennessee | 38119 | — |
| Clinical Research Associates, Inc. | Nashville | Tennessee | 37203 | — |
| Trinity Clinical Research | Tullahoma | Tennessee | 37388 | — |
| Benchmark Research | Austin | Texas | 78705 | — |
| Innovo Research - Austin Regional Clinic | Austin | Texas | 78726 | — |
| Tekton Research, Inc. | Austin | Texas | 78745 | — |
| North Texas Infectious Diseases Consultants, P.A. | Dallas | Texas | 75246 | — |
| Ventavia Research Group, LLC | Fort Worth | Texas | 76104 | — |
| Benchmark Research | Fort Worth | Texas | 76135 | — |
| Texas Health Resources | Fort Worth | Texas | 76135 | — |
| University of Texas Medical Branch | Galveston | Texas | 77555 | — |
| Hany H. Ahmed, MD | Houston | Texas | 77008 | — |
| Ventavia Research Group, LLC | Houston | Texas | 77008 | — |
| Texas Center for Drug Development, Inc. | Houston | Texas | 77081 | — |
| Ventavia Research Group, LLC | Keller | Texas | 76248 | — |
| SMS Clinical Research, LLC | Mesquite | Texas | 75149 | — |
| LinQ Research, LLC | Pearland | Texas | 77584 | — |
| Benchmark Research. | San Angelo | Texas | 76904 | — |
| Clinical Trials of Texas, Inc. | San Antonio | Texas | 78229 | — |
| Diagnostics Research Group | San Antonio | Texas | 78229 | — |
| Martin Diagnostic Clinic | Tomball | Texas | 77375 | — |
| J. Lewis Research, Inc. / Foothill Family Clinic | Salt Lake City | Utah | 84109 | — |
| J. Lewis Research, Inc. / Foothill Family Clinic South | Salt Lake City | Utah | 84121 | — |
| Clinical Alliance for Research & Education - Infectious Diseases, LLC (CARE-ID) | Annandale | Virginia | 22003 | — |
| Infectious Diseases Physicians, LLC | Annandale | Virginia | 22003 | — |
| Virginia Research Center LLC | Midlothian | Virginia | 23114 | — |
| Benaroya Research Institute at Virginia Mason | Seattle | Washington | 98101 | — |
| Wenatchee Valley Hospital | Wenatchee | Washington | 98801 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 21 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT04368728, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Mar 24, 2026 · Synced Jul 24, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete protocol, eligibility criteria, and contact information for NCT04368728 live on ClinicalTrials.gov.