Assessment of Efficacy and Safety of Ruxolitinib in Participants With COVID-19-Associated ARDS Who Require Mechanical Ventilation (RUXCOVID-DEVENT)
Public ClinicalTrials.gov record NCT04377620. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase 3, Randomized, Double-Blind, Placebo-Controlled, Multicenter Study to Assess the Efficacy and Safety of Ruxolitinib in Participants With COVID-19-Associated ARDS Who Require Mechanical Ventilation (RUXCOVID-DEVENT)
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
The purpose of this study is to evaluate the efficacy and safety of ruxolitinib in the treatment of participants with COVID-19-associated Acute Respiratory Distress Syndrome (ARDS) who require mechanical ventilation.
Study identification
- NCT ID
- NCT04377620
- Recruitment status
- Terminated
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 211 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 12 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- May 24, 2020 (Actual)
- Primary completion
- Feb 26, 2021 (Actual)
- Completion
- Feb 26, 2021 (Actual)
- Last update posted
- Jan 19, 2022
2020 – 2021
United States locations
- U.S. sites
- 35
- U.S. states
- 19
- U.S. cities
- 32
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Honor Health Research Institute | Scottsdale | Arizona | 85258 | — |
| Sharp Memorial Hospital | San Diego | California | 92123 | — |
| Georgetown University Hospital | Washington D.C. | District of Columbia | 20007 | — |
| Teradan Clinical Trials | Brandon | Florida | 33511 | — |
| University of Florida | Gainesville | Florida | 32610 | — |
| Tampa General Hospital | Tampa | Florida | 33606 | — |
| University of South Florida | Tampa | Florida | 33613 | — |
| Northshore University Health System | Chicago | Illinois | 60678 | — |
| Loyola University Medical Center | Maywood | Illinois | 60153 | — |
| Indiana University Simon Cancer Center | Indianapolis | Indiana | 46202 | — |
| Indiana University Health Central Indiana Cancer Centers | Indianapolis | Indiana | 46219 | — |
| East Jefferson General Hospital | Metairie | Louisiana | 70006 | — |
| Johns Hopkins University | Baltimore | Maryland | 21224 | — |
| Boston Medical Center | Boston | Massachusetts | 02118 | — |
| Lahey Hospital & Medical Center | Burlington | Massachusetts | 01805 | — |
| University of Massachusetts Medical School | Worcester | Massachusetts | 01655 | — |
| Healthpartners Cancer Care Center - Regions Hospital | Saint Paul | Minnesota | 55101 | — |
| Mercy Research | Springfield | Missouri | 65804 | — |
| Hackensack University Medical Center | Hackensack | New Jersey | 07601 | — |
| Rutgers Njms Clinical Research Unit | Newark | New Jersey | 07103 | — |
| Holy Name Medical Center | Teaneck | New Jersey | 07666 | — |
| University of Rochester Medical Center | Rochester | New York | 14642 | — |
| Duke University Medical Center | Durham | North Carolina | 27710 | — |
| East Carolina University | Greenville | North Carolina | 27858 | — |
| University of Cincinnati | Cincinnati | Ohio | 45219 | — |
| Kettering Cancer Care | Dayton | Ohio | 45429 | — |
| Jefferson University Hospitals | Philadelphia | Pennsylvania | 19107 | — |
| Temple University | Philadelphia | Pennsylvania | 19140 | — |
| West Penn Hospital | Pittsburgh | Pennsylvania | 15224 | — |
| Allegheny Health Network | Wexford | Pennsylvania | 15090 | — |
| St David'S Medical Center | Austin | Texas | 78705 | — |
| University of Texas Health Science Center At Houston - McGovern Medical School | Houston | Texas | 77030 | — |
| University of Texas Health Science Cente | San Antonio | Texas | 78229 | — |
| Wenatchee Valley Hospital and Clinics | Wenatchee | Washington | 98801 | — |
| Aurora Research Institute | Milwaukee | Wisconsin | 53233 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 1 non-U.S. site.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT04377620, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Jan 19, 2022 · Synced Oct 23, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT04377620 live on ClinicalTrials.gov.