SEMA4D Blockade Safety and Brain Metabolic Activity in Alzheimer's Disease (AD)
Public ClinicalTrials.gov record NCT04381468. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
SEMA4D Blockade Safety and Brain Metabolic Activity in Alzheimer's Disease (AD): A Multi-center, Randomized, Double-Blind, Placebo-Controlled Safety and Biomarker Study of Pepinemab Anti-SEMA4D Antibody in Early-AD
Study identification
- NCT ID
- NCT04381468
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 1, Phase 2
- Lead sponsor
- Vaccinex Inc.
- Industry
- Enrollment
- 50 participants
Conditions and interventions
Conditions
Interventions
- Pepinemab Drug
- Placebo Drug
Drug
Eligibility (public fields only)
- Age range
- 55 Years to 85 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Jul 21, 2021
- Primary completion
- Jun 4, 2024
- Completion
- Jun 4, 2024
- Last update posted
- Aug 21, 2024
2021 – 2024
United States locations
- U.S. sites
- 14
- U.S. states
- 7
- U.S. cities
- 14
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Pacific Research Network, Inc | San Diego | California | 92103 | — |
| Georgetown University | Washington D.C. | District of Columbia | 20057 | — |
| Brain Matters Research | Delray Beach | Florida | 33445 | — |
| Neuropsychiatric Research Center of Southwest Florida | Fort Myers | Florida | 33912 | — |
| JEM Research Institute | Lake Worth | Florida | 33462 | — |
| Premiere Research Institute of Palm Beach, Neurology | Palm Beach | Florida | 33480 | — |
| Brain Matters Research | Stuart | Florida | 34997 | — |
| Indiana University School of Medicine | Indianapolis | Indiana | 46202 | — |
| University of Kansas Medical Center | Fairway | Kansas | 66205 | — |
| Neurological Associates of Albany | Albany | New York | 12212 | — |
| Dent Neurological Associates | Amherst | New York | 14226 | — |
| Columbia University Irving Medical Center | New York | New York | 10032 | — |
| University of Rochester Medical Center | Rochester | New York | 14620 | — |
| Re-Cognition Health | Fairfax | Virginia | 22031 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT04381468, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Aug 21, 2024 · Synced Jul 22, 2026
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Open the official record
The complete protocol, eligibility criteria, and contact information for NCT04381468 live on ClinicalTrials.gov.