Patient-Reported Outcomes in Evaluating Lorecivivint (SM04690) for Moderate to Severe Knee Osteoarthritis (STRIDES-1)
Public ClinicalTrials.gov record NCT04385303. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A 28-Week, Multicenter, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate a Single Injection of SM04690 Injected in the Target Knee Joint of Moderately to Severely Symptomatic Osteoarthritis Subjects
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
This phase 3 study is a multicenter, randomized, double-blind, placebo-controlled study of lorecivivint injected intraarticularly (IA) into the target knee (most painful) joint of moderately to severely symptomatic osteoarthritis (OA) subjects at a single dose of 0.07 mg lorecivivint per 2 mL injection. This study will utilize patient reported outcomes (PROs) to evaluate the safety and efficacy of lorecivivint.
Study identification
- NCT ID
- NCT04385303
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 496 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 40 Years to 80 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- May 26, 2020 (Actual)
- Primary completion
- Sep 8, 2021 (Actual)
- Completion
- Sep 8, 2021 (Actual)
- Last update posted
- Feb 4, 2026
2020 – 2021
United States locations
- U.S. sites
- 76
- U.S. states
- 30
- U.S. cities
- 72
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Research Site | Birmingham | Alabama | 35205 | — |
| Research Site | Birmingham | Alabama | 35215 | — |
| Research Site | Mobile | Alabama | 36608 | — |
| Research Site | Phoenix | Arizona | 85018 | — |
| Research Site | Phoenix | Arizona | 85053 | — |
| Research Site | Tucson | Arizona | 85712 | — |
| Research Site | Little Rock | Arkansas | 72205 | — |
| Research Site | Anaheim | California | 92805 | — |
| Research Site | Beverly Hills | California | 90211 | — |
| Research Site | Canoga Park | California | 91303 | — |
| Research Site | Garden Grove | California | 92840 | — |
| Research Site | La Mesa | California | 91942 | — |
| Research Site | Norco | California | 92860 | — |
| Research Site | Pomona | California | 91767 | — |
| Research Site | San Diego | California | 92103 | — |
| Research Site | Santa Monica | California | 90404 | — |
| Research Site | Thousand Oaks | California | 91360 | — |
| Research Site | Westminster | California | 92683 | — |
| Research Site | Boulder | Colorado | 80301 | — |
| Research Site | Hamden | Connecticut | 06517 | — |
| Reserach Site | Clearwater | Florida | 33761 | — |
| Research Site | Edgewater | Florida | 32132 | — |
| Research Site | Gulf Breeze | Florida | 32561 | — |
| Research Site | Miami | Florida | 33125 | — |
| Research Site | Miami | Florida | 33173 | — |
| Research Site | Miami Lakes | Florida | 33014 | — |
| Research Site | Sunrise | Florida | 33351 | — |
| Research Site | Sweetwater | Florida | 33172 | — |
| Research Site | West Palm Beach | Florida | 33409 | — |
| Research Site | Winter Haven | Florida | 33880 | — |
| Research Site 1 | Winter Park | Florida | 32789 | — |
| Research Site | Marietta | Georgia | 30060 | — |
| Research Site | Newnan | Georgia | 30265 | — |
| Research Site | Woodstock | Georgia | 30189 | — |
| Research Site | Boise | Idaho | 83713 | — |
| Research Site | Chicago | Illinois | 60607 | — |
| Research Site | Gurnee | Illinois | 60031 | — |
| Research Site | Oak Brook | Illinois | 60523 | — |
| Research Site | Evansville | Indiana | 47714 | — |
| Research Site | Greenwood | Indiana | 46143 | — |
| Research Site | Valparaiso | Indiana | 46383 | — |
| Research Site | New Orleans | Louisiana | 70124 | — |
| Research Site | Wheaton | Maryland | 20902 | — |
| Research Site | Boston | Massachusetts | 02111 | — |
| Research Site | Troy | Michigan | 48085 | — |
| Research Site | Hazelwood | Missouri | 63042 | — |
| Research Site | Kansas City | Missouri | 64114 | — |
| Research Site 1 | St Louis | Missouri | 63141 | — |
| Research Site 2 | St Louis | Missouri | 63141 | — |
| Research Site | Omaha | Nebraska | 68114 | — |
| Research Site | Las Vegas | Nevada | 89119 | — |
| Research Site | Reno | Nevada | 89519 | — |
| Research Site | Freehold | New Jersey | 07728 | — |
| Research Site | Albuquerque | New Mexico | 87102 | — |
| Research Site | Hartsdale | New York | 10530 | — |
| Research Site | Rochester | New York | 14642 | — |
| Research Site | Greensboro | North Carolina | 27408 | — |
| Research Site | Salisbury | North Carolina | 28144 | — |
| Research Site | Winston-Salem | North Carolina | 27103 | — |
| Research Site | Cincinnati | Ohio | 45224 | — |
| Research Site | Edmond | Oklahoma | 73013 | — |
| Research Site | Duncansville | Pennsylvania | 16635 | — |
| Research Site | Charleston | South Carolina | 29406 | — |
| Research Site | Fort Mill | South Carolina | 29707 | — |
| Research Site | Mt. Pleasant | South Carolina | 29464 | — |
| Research Site | Rapid City | South Dakota | 57702 | — |
| Research Site | Bellaire | Texas | 77401 | — |
| Research Site | Carrollton | Texas | 75007 | — |
| Research Site | Dallas | Texas | 75231 | — |
| Research Site | Houston | Texas | 77029 | — |
| Research Site | Plano | Texas | 75075 | — |
| Research Site | Draper | Utah | 84020 | — |
| Research Site | Ogden | Utah | 84405 | — |
| Research Site | Salt Lake City | Utah | 84107 | — |
| Research Site | Charlottesville | Virginia | 22911 | — |
| Research Site | Richmond | Virginia | 23219 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT04385303, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Feb 4, 2026 · Synced Oct 18, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT04385303 live on ClinicalTrials.gov.