A Study to Evaluate the Safety and Efficacy of MSTT1041A (Astegolimab) or UTTR1147A in Patients With Severe COVID-19 Pneumonia
Public ClinicalTrials.gov record NCT04386616. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase II, Randomized, Double-Blind, Placebo-Controlled, Multicenter Study to Evaluate the Safety and Efficacy of MSTT1041A or UTTR1147A in Patients With Severe COVID-19 Pneumonia
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
This is a Phase II, randomized, double-blind, placebo-controlled, multicenter study to assess the efficacy and safety of MSTT1041A (astegolimab) compared with placebo and of UTTR1147A compared with placebo, in combination with standard of care (SOC), in patients hospitalized with severe coronavirus disease 2019 (COVID-19) pneumonia.
Study identification
- NCT ID
- NCT04386616
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 2
- Enrollment
- 396 participants
Conditions and interventions
Conditions
Interventions
- MSTT1041A Drug
- MSTT1041A-matched Placebo Drug
- UTTR1147A Drug
- UTTR1147A-matched Placebo Drug
Drug
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Jun 2, 2020 (Actual)
- Primary completion
- Jan 8, 2021 (Actual)
- Completion
- Feb 12, 2021 (Actual)
- Last update posted
- Jan 10, 2022
2020 – 2021
United States locations
- U.S. sites
- 24
- U.S. states
- 16
- U.S. cities
- 23
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| University of Arkansas For Medical Sciences | Little Rock | Arkansas | 72205 | — |
| eStudySite - Chula Vista - PPDS | Chula Vista | California | 91911 | — |
| eStudySite | La Mesa | California | 91942 | — |
| Torrance Memorial Medical Center | Torrance | California | 90505 | — |
| Denver Health Medical Center | Denver | Colorado | 80204 | — |
| Bay Pines VA Medical Center - NAVREF | Bay Pines | Florida | 33744 | — |
| WellStar Research Institute | Marietta | Georgia | 30060 | — |
| DM Clinical Research - Alexandria Cardiology Clinic - ERN - PPDS | Alexandria | Louisiana | 71301 | — |
| MedPharmics | Metairie | Louisiana | 70006 | — |
| Southeast Louisiana Veterans Health Care System - NAVREF | New Orleans | Louisiana | 70112 | — |
| Henry Ford Health System | Detroit | Michigan | 48202 | — |
| St. Joseph'S Regional Medical Center | Paterson | New Jersey | 07503 | — |
| San Juan Oncology Associates | Farmington | New Mexico | 87401 | — |
| Albany Medical Center | Albany | New York | 12208 | — |
| Staten Island University Hospital; Department of Pharmacy | Staten Island | New York | 10305 | — |
| Lincoln Medical Mental Health Center | The Bronx | New York | 10451 | — |
| Mercy St. Vincent Medical Center | Toledo | Ohio | 43608 | — |
| Providence Portland Medical Center; Investigational Drug Services/Regional Research | Portland | Oregon | 97213 | — |
| Lehigh Valley Health Network | Allentown | Pennsylvania | 18103 | — |
| Parkland Health & Hospital System | Dallas | Texas | 75235 | — |
| University of Texas Southwestern Medical Center | Dallas | Texas | 75390 | — |
| Virginia Commonwealth University | Richmond | Virginia | 23292 | — |
| Virginia Mason Medical Center | Seattle | Washington | 98101 | — |
| MultiCare Institute for Research and Innovation; Clinic/Outpatient Facility | Tacoma | Washington | 98405 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 17 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT04386616, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Jan 10, 2022 · Synced Oct 19, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT04386616 live on ClinicalTrials.gov.