A Study of Sigvotatug Vedotin in Advanced Solid Tumors

ClinicalTrials.gov ID: NCT04389632

Public ClinicalTrials.gov record NCT04389632. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

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ClinicalTrials.gov public records Last synced May 3, 2026, 11:38 PM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Official title

A Phase 1 Study of Sigvotatug Vedotin in Advanced Solid Tumors

Study identification

NCT ID: NCT04389632
Recruitment status: Recruiting
Study type: Interventional
Phase: Phase 1
Lead sponsor: Seagen, a wholly owned subsidiary of Pfizer; Industry
Enrollment: 1,006 participants

Conditions and interventions

Conditions

Interventions

carboplatin Drug
cisplatin Drug
pembrolizumab Drug
sigvotatug vedotin Drug

Drug

Eligibility (public fields only)

Age range: 18 Years and older
Sex: All
Healthy volunteers: Healthy volunteers not accepted

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date: Jun 7, 2020
Primary completion: Jun 15, 2027
Completion: Mar 21, 2029
Last update posted: Apr 19, 2026

2020 – 2029

United States locations

U.S. sites: 106
U.S. states: 19
U.S. cities: 64

Facility	City	State	ZIP	Site status
Alaska Oncology and Hematology	Anchorage	Alaska	99508	Recruiting
Highlands Oncology Group	Fayetteville	Arkansas	72703	Recruiting
Highlands Oncology Group	Rogers	Arkansas	72758	Recruiting
Highlands Oncology Group	Springdale	Arkansas	72762	Recruiting
Providence Medical Foundation	Anaheim	California	92805	Recruiting
Providence Medical Foundation	Fullerton	California	92835	Recruiting
Providence St. Jude Medical Center Virginia K Crosson and Infusion Center	Fullerton	California	92835	Recruiting
Cancer and Blood Research Center, LLC	Los Alamitos	California	90720	Not yet recruiting
Cancer and Blood Specialty Clinic	Los Alamitos	California	90720	Not yet recruiting
Ronald Reagan UCLA Medical Center	Los Angeles	California	90095	Recruiting
The Regents of the University of California	Los Angeles	California	90095	Recruiting
UCLA Department of Medicine-Hematology/Oncology	Los Angeles	California	90095	Recruiting
UCLA Department of Medicine - Hematology & Oncology	Santa Monica	California	90404	Recruiting
Cancer AND Blood Specialty Clinic	Torrance	California	90505	Not yet recruiting
American Oncology Partners, PA. a Florida professional service corporation, d/b/a Vista Oncology	Fort Myers	Florida	33913	Recruiting
Florida Cancer Specialists & Research Institute, LLC	Fort Myers	Florida	33916	Recruiting
Memorial Cancer Institute	Hollywood	Florida	33021	Recruiting
Memorial Healthcare System	Hollywood	Florida	33021	Recruiting
Florida Cancer Specialists	Orlando	Florida	32827	Recruiting
Memorial Cancer Institute at Memorial Hospital West	Pembroke Pines	Florida	33028	Recruiting
Memorial Hospital West	Pembroke Pines	Florida	33028	Recruiting
Ingalls Family Care Center	Calumet City	Illinois	60409	Recruiting
UChicago Medicine - River East	Chicago	Illinois	60611	Recruiting
The University Of Chicago	Chicago	Illinois	60637	Recruiting
University of Chicago Medical Center	Chicago	Illinois	60637	Recruiting
UChicago Medicine at Ingalls - Flossmoor	Flossmoor	Illinois	60422	Recruiting
UChicago Medicine Ingalls Memorial	Harvey	Illinois	60426	Recruiting
University of Chicago Comprehensive Cancer Center at Silver Cross Hospital	New Lenox	Illinois	60451	Recruiting
The University of Chicago Medicine Center for Advanced Care Orland Park	Orland Park	Illinois	60462	Recruiting
Southern Illinois University - Simmons Cancer Institute	Springfield	Illinois	62702	Recruiting
Springfield Clinic Radiology - 800 Building	Springfield	Illinois	62702	Recruiting
Springfield Clinic	Springfield	Illinois	62702	Recruiting
Springfield Clinic Main Campus	Springfield	Illinois	62703	Recruiting
Springfield Clinic Radiology - Main Campus	Springfield	Illinois	62703	Recruiting
Springfield Memorial Hospital	Springfield	Illinois	62781	Recruiting
UChicago Medicine at Ingalls - Tinley Park	Tinley Park	Illinois	60477	Recruiting
UChicago Medicine - Northwest Indiana	Crown Point	Indiana	46307	Recruiting
Fort Wayne Medical Oncology and Hematology, Inc	Fort Wayne	Indiana	46804	Recruiting
Community Health Network, Inc	Indianapolis	Indiana	46219	Recruiting
Community Health Network, Inc.	Indianapolis	Indiana	46227	Recruiting
Community Health Network Investigational Drug Services	Indianapolis	Indiana	46250	Recruiting
Community Health Network, Inc.	Indianapolis	Indiana	46250	Recruiting
Community Health Network	Indianapolis	Indiana	46256	Recruiting
The University of Kansas Cancer Center, Investigational Drug Services	Fairway	Kansas	66205	Recruiting
The University of Kansas Clinical Research Center	Fairway	Kansas	66205	Recruiting
The University of Kansas Hospital	Kansas City	Kansas	66160	Recruiting
The University of Kansas Medical Center Medical Office Building	Kansas City	Kansas	66160	Recruiting
University of Kansas Hospital Cambridge North Tower A	Kansas City	Kansas	66160	Recruiting
University of Kansas Medical Center Research Institute	Kansas City	Kansas	66160	Recruiting
The University of Kansas Cancer Center - Indian Creek Campus	Overland Park	Kansas	66211	Recruiting
The University of Kansas Cancer Center - Westwood	Westwood	Kansas	66205	Recruiting
University of Kansas Cancer Center	Westwood	Kansas	66205	Recruiting
Massachusetts General Hospital	Boston	Massachusetts	02114	Recruiting
Brigham & Women's Hospital	Boston	Massachusetts	02115	Recruiting
Beth Israel Deaconess Medical Center,East Campus Research Pharmacy	Boston	Massachusetts	02215	Recruiting
Beth Israel Deaconess Medical Center	Boston	Massachusetts	02215	Recruiting
Dana Farber Cancer Institute	Boston	Massachusetts	02215	Recruiting
Dana-Farber Cancer Institute - Chestnut Hill	Newton	Massachusetts	02467	Recruiting
Allina Health Cancer Institute - Mercy Hospital	Coon Rapids	Minnesota	55433	Recruiting
Allina Health Cancer Institute - Abbott Northwestern Hospital	Minneapolis	Minnesota	55407	Recruiting
Allina Health Cancer Institute	Saint Paul	Minnesota	55102	Recruiting
Comprehensive Cancer Centers of Nevada	Las Vegas	Nevada	89169	Recruiting
North Shore Hematology Oncology Associates P.C. DBA New York Cancer and Blood Specialists	Babylon	New York	11702	Recruiting
North Shore Hematology Oncology Associates P.C. DBA New York Cancer and Blood Specialists	Brooklyn	New York	11210	Recruiting
North Shore Hematology Oncology Associates P.C. DBA New York Cancer and Blood Specialists	New Hyde Park	New York	11042	Recruiting
North Shore Hematology Oncology Associates P.C. DBA New York Cancer and Blood Specialists	New York	New York	10028	Recruiting
Columbia University Irving Medical Center	New York	New York	10032	Recruiting
North Shore Hematology Oncology Associates P.C. DBA New York Cancer and Blood Specialists	Patchogue	New York	11772	Recruiting
North Shore Hematology Oncology Associates P.C. DBA New York Cancer and Blood Specialists	Port Jefferson Station	New York	11776	Recruiting
North Shore Hematology Oncology Associates P.C. DBA New York Cancer and Blood Specialists	Riverhead	New York	11901	Recruiting
North Shore Hematology Oncology Associates P.C. DBA New York Cancer and Blood Specialists	Shirley	New York	11967	Recruiting
North Shore Hematology Oncology Associates P.C. DBA New York Cancer and Blood Specialists	The Bronx	New York	10469	Recruiting
University Hospitals Cleveland Medical Center	Cleveland	Ohio	44106	Active, not recruiting
OU Health University of Oklahoma Medical Center	Oklahoma City	Oklahoma	73104	Recruiting
Stephenson Cancer Center (chemo location)	Oklahoma City	Oklahoma	73104	Recruiting
University of Oklahoma Health Science Center	Oklahoma City	Oklahoma	73104	Recruiting
Providence Cancer Institute Franz Clinic	Portland	Oregon	97213	Recruiting
Providence Oncology and Hematology Care Clinic - Westside	Portland	Oregon	97225	Recruiting
Providence St. Vincent Medical Center- Investigational Drug Services	Portland	Oregon	97225	Recruiting
Providence St. Vincent Medical Center	Portland	Oregon	97225	Recruiting
Sanford Cancer Center	Sioux Falls	South Dakota	57104	Recruiting
Sanford Research	Sioux Falls	South Dakota	57104	Recruiting
Sanford USD Medical Center	Sioux Falls	South Dakota	57105	Recruiting
US Oncology Research LLC	Nashville	Tennessee	37203	Recruiting
Oncology Consultants, PA	Houston	Texas	77024	Recruiting
Oncology Consultants, PA.	Houston	Texas	77030	Recruiting
The University of Texas M.D. Anderson Cancer Center	Houston	Texas	77030	Recruiting
US Oncology Investigational Product Center (IPC)	Irving	Texas	75063	Recruiting
Houston Medical Imaging	Pearland	Texas	77581	Not yet recruiting
South Texas Accelerated Research Therapeutics, LLC	San Antonio	Texas	78229	Active, not recruiting
UT Health East Texas HOPE Cancer Center	Tyler	Texas	75701	Recruiting
UT Health East Texas Hope Cancer Center	Tyler	Texas	75708	Recruiting
Tranquil Clinical Research	Webster	Texas	77598	Not yet recruiting
Virginia Cancer Specialists	Fairfax	Virginia	22031	Recruiting
Northwest Medical Specialities. PLLC	Bonney Lake	Washington	98391	Not yet recruiting
Swedish Cancer Institute - Edmonds Campus	Edmonds	Washington	98026	Recruiting
Swedish Cancer Institute Edmonds Campus	Edmonds	Washington	98026	Recruiting
Northwest Medical Specialities.PLLC	Federal Way	Washington	98003	Not yet recruiting
Northwest Medical Specialities. PLLC	Gig Harbor	Washington	98332	Not yet recruiting
American Oncology Network Vista Oncology Division-West office	Olympia	Washington	98502	Recruiting
American Oncology Network Vista Oncology Division-East office	Olympia	Washington	98506	Recruiting
Northwest Medical Specialties, PPLC	Puyallup	Washington	98373	Not yet recruiting
Swedish Cancer Institute	Seattle	Washington	98104	Recruiting
Swedish Medical Center	Seattle	Washington	98122	Recruiting
Exigent Research, LLC	Tacoma	Washington	98405	Not yet recruiting
Northwest Medical Specialities, PLLC	Tacoma	Washington	98405	Not yet recruiting

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

Non-U.S. locations

This page focuses on the U.S. directory. The official record also lists 52 non-U.S. sites.

About this trial record page

What this page shows: Public field values for ClinicalTrials.gov record NCT04389632, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do: No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from: Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh: Last update posted Apr 19, 2026 · Synced May 3, 2026

Open the official record

The complete protocol, eligibility criteria, and contact information for NCT04389632 live on ClinicalTrials.gov.

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