Abemaciclib and Letrozole to Treat Endometrial Cancer
Public ClinicalTrials.gov record NCT04393285. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase II Study of Abemaciclib in Combination With Letrozole in Advanced, Recurrent or Metastatic Endometroid Endometrial Cancer
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
This is a phase II single arm trial to determine the percentage of patients without evidence of disease progression on abemaciclib and letrozole in advanced stage, persistent or recurrent endometrioid endometrial cancer at 6 months. Treatment will continue until either unacceptable toxicity, progression of disease, or investigator/patient request for withdrawal.
Study identification
- NCT ID
- NCT04393285
- Recruitment status
- Active, not recruiting
- Study type
- Interventional
- Phase
- Phase 2
- Enrollment
- 53 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- Female
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Oct 10, 2020 (Actual)
- Primary completion
- Dec 1, 2026 (Estimated)
- Completion
- Dec 31, 2026 (Estimated)
- Last update posted
- Mar 9, 2026
2020 – 2026
United States locations
- U.S. sites
- 29
- U.S. states
- 16
- U.S. cities
- 27
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| University of South Alabama Mitchell Cancer Center | Mobile | Alabama | 36604 | — |
| Alaska Women's Cancer Care | Anchorage | Alaska | 99508 | — |
| Smillow Cancer Care at Greenwich | Greenwich | Connecticut | 06830 | — |
| Yale University | New Haven | Connecticut | 06520 | — |
| Sylvester Comprehensive Cancer Center-Lennar Foundation Medical Center | Coral Gables | Florida | 33146 | — |
| Sylevester Comprehensive Cancer Center-Deerfield Beach | Deerfield Beach | Florida | 33442 | — |
| UF Health Cancer Center | Gainesville | Florida | 32160 | — |
| University of Miami - Sylvester Cancer Center | Miami | Florida | 33136 | — |
| UT Health Tower | Miami | Florida | 33136 | — |
| Advent Health - Orlando | Orlando | Florida | 32804 | — |
| Sylvester Comprehensive Cancer Center-Plantation | Plantation | Florida | 33324 | — |
| Cleveland Clinic Florida | Weston | Florida | 33331 | — |
| Lewis Cancer & Research Pavilion | Savannah | Georgia | 31405 | — |
| University of Chicago | Chicago | Illinois | 60637 | — |
| Baptist Healthcare System | Lexington | Kentucky | 40503 | — |
| Tufts Medical Center | Boston | Massachusetts | 02111 | — |
| University of Massachusetts | Worcester | Massachusetts | 01605 | — |
| St. Joseph Mercy Hospital | Ann Arbor | Michigan | 48106 | — |
| Rutgers Cancer Institute of New Jersey | New Brunswick | New Jersey | 08903 | — |
| Holy Name Medical Center | Teaneck | New Jersey | 07666 | — |
| Columbia University Medical Center | New York | New York | 10032 | — |
| SUNY Upstate Medical University | Syracuse | New York | 13210 | — |
| Oklahoma Cancer Specialists and Research Institute | Tulsa | Oklahoma | 74146 | — |
| Reading Hospital-McGlinn Cancer Institute | Reading | Pennsylvania | 19611 | — |
| Abington Memorial Hospital | Willow Grove | Pennsylvania | 19090 | — |
| Baptist Health Center Lexington | Salt Lake City | Utah | 84112 | — |
| Huntsman Cancer Institute | Salt Lake City | Utah | 84112 | — |
| University of Virginia | Charlottesville | Virginia | 22908 | — |
| West Virginia University | Morgantown | West Virginia | 26506 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT04393285, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Mar 9, 2026 · Synced Oct 19, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT04393285 live on ClinicalTrials.gov.