ClinicalTrials.gov record
Completed Phase 2Phase 3 Interventional Results available

Testing the Use of the Immunotherapy Drugs Ipilimumab and Nivolumab Plus Radiation Therapy Compared to the Usual Treatment (Temozolomide and Radiation Therapy) for Newly Diagnosed MGMT Unmethylated Glioblastoma

ClinicalTrials.gov ID: NCT04396860

Public ClinicalTrials.gov record NCT04396860. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

ClinicalTrials.gov public records Last synced May 20, 2026, 4:09 AM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Official title

A Randomized Phase II/III Open-Label Study of Ipilimumab and Nivolumab Versus Temozolomide in Patients With Newly Diagnosed MGMT (Tumor O-6-Methylguanine DNA Methyltransferase) Unmethylated Glioblastoma

Study identification

NCT ID
NCT04396860
Recruitment status
Completed
Study type
Interventional
Phase
Phase 2, Phase 3
Lead sponsor
National Cancer Institute (NCI)
NIH
Enrollment
159 participants

Conditions and interventions

Interventions

  • Contrast-enhanced Magnetic Resonance Imaging Procedure
  • Ipilimumab Biological
  • Nivolumab Biological
  • NovoTTF-100A Device Device
  • Quality-of-Life Assessment Other
  • Questionnaire Administration Other
  • Radiation Therapy Radiation
  • Temozolomide Drug

Procedure · Biological · Device + 3 more

Eligibility (public fields only)

Age range
18 Years and older
Sex
All
Healthy volunteers
Healthy volunteers not accepted

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date
Aug 31, 2020
Primary completion
Jan 12, 2023
Completion
Dec 22, 2025
Last update posted
Apr 21, 2026

2020 – 2025

United States locations

U.S. sites
285
U.S. states
42
U.S. cities
213
Facility City State ZIP Site status
University of Alabama at Birmingham Cancer Center Birmingham Alabama 35233
University of Arkansas for Medical Sciences Little Rock Arkansas 72205
Kaiser Permanente-Anaheim Anaheim California 92806
Sutter Auburn Faith Hospital Auburn California 95602
Sutter Cancer Centers Radiation Oncology Services-Auburn Auburn California 95603
John Muir Medical Center-Concord Concord California 94520
UC San Diego Moores Cancer Center La Jolla California 92093
Loma Linda University Medical Center Loma Linda California 92354
Kaiser Permanente Los Angeles Medical Center Los Angeles California 90027
Cedars Sinai Medical Center Los Angeles California 90048
Kaiser Permanente-Ontario Ontario California 91761
UC Irvine Health/Chao Family Comprehensive Cancer Center Orange California 92868
Sutter Cancer Centers Radiation Oncology Services-Roseville Roseville California 95661
Sutter Roseville Medical Center Roseville California 95661
Sutter Medical Center Sacramento Sacramento California 95816
University of California Davis Comprehensive Cancer Center Sacramento California 95817
Torrance Memorial Physician Network - Cancer Care Torrance California 90505
Torrance Memorial Medical Center Torrance California 90509
John Muir Medical Center-Walnut Creek Walnut Creek California 94598
Penrose-Saint Francis Healthcare Colorado Springs Colorado 80907
AdventHealth Porter Denver Colorado 80210
AdventHealth Littleton Littleton Colorado 80122
AdventHealth Parker Parker Colorado 80138
Hartford Hospital Hartford Connecticut 06102
The Hospital of Central Connecticut New Britain Connecticut 06050
Beebe Medical Center Lewes Delaware 19958
Beebe South Coastal Health Campus Millville Delaware 19967
Delaware Clinical and Laboratory Physicians PA Newark Delaware 19713
Helen F Graham Cancer Center Newark Delaware 19713
Medical Oncology Hematology Consultants PA Newark Delaware 19713
Christiana Care Health System-Christiana Hospital Newark Delaware 19718
Beebe Health Campus Rehoboth Beach Delaware 19971
Baptist MD Anderson Cancer Center Jacksonville Florida 32207
AdventHealth Orlando Orlando Florida 32803
Augusta University Medical Center Augusta Georgia 30912
Memorial Health University Medical Center Savannah Georgia 31404
Lewis Cancer and Research Pavilion at Saint Joseph's/Candler Savannah Georgia 31405
Lewis Hall Singletary Oncology Center Thomasville Georgia 31792
Hawaii Cancer Care Inc - Waterfront Plaza Honolulu Hawaii 96813
Island Urology Honolulu Hawaii 96813
Queen's Cancer Cenrer - POB I Honolulu Hawaii 96813
Queen's Medical Center Honolulu Hawaii 96813
Straub Clinic and Hospital Honolulu Hawaii 96813
University of Hawaii Cancer Center Honolulu Hawaii 96813
Hawaii Cancer Care Inc-Liliha Honolulu Hawaii 96817
Queen's Cancer Center - Kuakini Honolulu Hawaii 96817
The Cancer Center of Hawaii-Liliha Honolulu Hawaii 96817
Kapiolani Medical Center for Women and Children Honolulu Hawaii 96826
Castle Medical Center Kailua Hawaii 96734
Wilcox Memorial Hospital and Kauai Medical Clinic Lihue Hawaii 96766
Hawaii Cancer Care - Westridge ‘Aiea Hawaii 96701
Pali Momi Medical Center ‘Aiea Hawaii 96701
Queen's Cancer Center - Pearlridge ‘Aiea Hawaii 96701
The Cancer Center of Hawaii-Pali Momi ‘Aiea Hawaii 96701
Saint Luke's Cancer Institute - Boise Boise Idaho 83712
Saint Alphonsus Cancer Care Center-Caldwell Caldwell Idaho 83605
Saint Luke's Cancer Institute - Fruitland Fruitland Idaho 83619
Saint Luke's Cancer Institute - Meridian Meridian Idaho 83642
Saint Alphonsus Cancer Care Center-Nampa Nampa Idaho 83687
Saint Luke's Cancer Institute - Nampa Nampa Idaho 83687
Saint Luke's Cancer Institute - Twin Falls Twin Falls Idaho 83301
Illinois CancerCare-Bloomington Bloomington Illinois 61704
Illinois CancerCare-Canton Canton Illinois 61520
Illinois CancerCare-Carthage Carthage Illinois 62321
Centralia Oncology Clinic Centralia Illinois 62801
Northwestern University Chicago Illinois 60611
University of Illinois Chicago Illinois 60612
Carle at The Riverfront Danville Illinois 61832
Northwestern Medicine Cancer Center Kishwaukee DeKalb Illinois 60115
Cancer Care Specialists of Illinois - Decatur Decatur Illinois 62526
Decatur Memorial Hospital Decatur Illinois 62526
Carle Physician Group-Effingham Effingham Illinois 62401
Crossroads Cancer Center Effingham Illinois 62401
Elmhurst Memorial Hospital Elmhurst Illinois 60126
Illinois CancerCare-Eureka Eureka Illinois 61530
NorthShore University HealthSystem-Evanston Hospital Evanston Illinois 60201
Illinois CancerCare-Galesburg Galesburg Illinois 61401
Western Illinois Cancer Treatment Center Galesburg Illinois 61401
Northwestern Medicine Cancer Center Delnor Geneva Illinois 60134
NorthShore University HealthSystem-Glenbrook Hospital Glenview Illinois 60026
NorthShore University HealthSystem-Highland Park Hospital Highland Park Illinois 60035
Illinois CancerCare-Kewanee Clinic Kewanee Illinois 61443
Illinois CancerCare-Macomb Macomb Illinois 61455
Carle Physician Group-Mattoon/Charleston Mattoon Illinois 61938
Edward Hospital/Cancer Center Naperville Illinois 60540
Cancer Care Center of O'Fallon O'Fallon Illinois 62269
Illinois CancerCare-Ottawa Clinic Ottawa Illinois 61350
Advocate Lutheran General Hospital Park Ridge Illinois 60068
Illinois CancerCare-Pekin Pekin Illinois 61554
Illinois CancerCare-Peoria Peoria Illinois 61615
Methodist Medical Center of Illinois Peoria Illinois 61636
OSF Saint Francis Medical Center Peoria Illinois 61637
Illinois CancerCare-Peru Peru Illinois 61354
Illinois CancerCare-Princeton Princeton Illinois 61356
UW Health Carbone Cancer Center Rockford Rockford Illinois 61114
Southern Illinois University School of Medicine Springfield Illinois 62702
Springfield Clinic Springfield Illinois 62702
Springfield Memorial Hospital Springfield Illinois 62781
Carle Cancer Center Urbana Illinois 61801
The Carle Foundation Hospital Urbana Illinois 61801
Northwestern Medicine Cancer Center Warrenville Warrenville Illinois 60555
Illinois CancerCare - Washington Washington Illinois 61571
Indiana University/Melvin and Bren Simon Cancer Center Indianapolis Indiana 46202
IU Health Methodist Hospital Indianapolis Indiana 46202
Mary Greeley Medical Center Ames Iowa 50010
McFarland Clinic - Ames Ames Iowa 50010
Mercy Cancer Center-West Lakes Clive Iowa 50325
UI Health Care Mission Cancer and Blood - West Des Moines Clinic Clive Iowa 50325
Heartland Oncology and Hematology LLP Council Bluffs Iowa 51503
Methodist Jennie Edmundson Hospital Council Bluffs Iowa 51503
Greater Regional Medical Center Creston Iowa 50801
Iowa Methodist Medical Center Des Moines Iowa 50309
UI Health Care Mission Cancer and Blood - Des Moines Clinic Des Moines Iowa 50309
Broadlawns Medical Center Des Moines Iowa 50314
Mercy Medical Center - Des Moines Des Moines Iowa 50314
UI Health Care Mission Cancer and Blood - Laurel Clinic Des Moines Iowa 50314
University of Iowa/Holden Comprehensive Cancer Center Iowa City Iowa 52242
Mercy Medical Center-West Lakes West Des Moines Iowa 50266
University of Kentucky/Markey Cancer Center Lexington Kentucky 40536
Tulane University School of Medicine New Orleans Louisiana 70112
Ochsner Medical Center Jefferson New Orleans Louisiana 70121
Eastern Maine Medical Center Bangor Maine 04401
MaineHealth Coastal Cancer Treatment Center Bath Maine 04530
MaineHealth Waldo Hospital Belfast Maine 04915
Lafayette Family Cancer Center-EMMC Brewer Maine 04412
MaineHealth Maine Medical Center - Portland Portland Maine 04102
Penobscot Bay Medical Center Rockport Maine 04856
MaineHealth Cancer Care Center of York County Sanford Maine 04073
Maine Medical Partners Neurology Scarborough Maine 04074
MaineHealth Maine Medical Center- Scarborough Scarborough Maine 04074
MaineHealth Cancer Care and IV Therapy - South Portland South Portland Maine 04106
University of Maryland/Greenebaum Cancer Center Baltimore Maryland 21201
UM Upper Chesapeake Medical Center Bel Air Maryland 21014
Central Maryland Radiation Oncology in Howard County Columbia Maryland 21044
UM Baltimore Washington Medical Center/Tate Cancer Center Glen Burnie Maryland 21061
Trinity Health Saint Joseph Mercy Hospital Ann Arbor Ann Arbor Michigan 48106
Trinity Health IHA Medical Group Hematology Oncology - Brighton Brighton Michigan 48114
Trinity Health Medical Center - Brighton Brighton Michigan 48114
Trinity Health IHA Medical Group Hematology Oncology - Canton Canton Michigan 48188
Trinity Health Medical Center - Canton Canton Michigan 48188
Chelsea Hospital Chelsea Michigan 48118
Trinity Health IHA Medical Group Hematology Oncology - Chelsea Hospital Chelsea Michigan 48118
Corewell Health Dearborn Hospital Dearborn Michigan 48124
Henry Ford Health Saint John Hospital Detroit Michigan 48236
Genesys Hurley Cancer Institute Flint Michigan 48503
Hurley Medical Center Flint Michigan 48503
Corewell Health Grand Rapids Hospitals - Butterworth Hospital Grand Rapids Michigan 49503
Bronson Methodist Hospital Kalamazoo Michigan 49007
West Michigan Cancer Center Kalamazoo Michigan 49007
Beacon Kalamazoo Kalamazoo Michigan 49048
Trinity Health Saint Mary Mercy Livonia Hospital Livonia Michigan 48154
Michigan Healthcare Professionals Pontiac Pontiac Michigan 48341
Corewell Health William Beaumont University Hospital Royal Oak Michigan 48073
MyMichigan Medical Center Saginaw Saginaw Michigan 48601
Oncology Hematology Associates of Saginaw Valley PC Saginaw Michigan 48604
MyMichigan Medical Center Tawas Tawas City Michigan 48764
Corewell Health Beaumont Troy Hospital Troy Michigan 48085
Henry Ford Health Warren Hospital Warren Michigan 48093
Saint Mary's Oncology/Hematology Associates of West Branch West Branch Michigan 48661
University of Michigan Health - West Wyoming Michigan 49519
Trinity Health IHA Medical Group Hematology Oncology Ann Arbor Campus Ypsilanti Michigan 48197
Sanford Joe Lueken Cancer Center Bemidji Minnesota 56601
Fairview Ridges Hospital Burnsville Minnesota 55337
Minnesota Oncology - Burnsville Burnsville Minnesota 55337
Mercy Hospital Coon Rapids Minnesota 55433
Fairview Southdale Hospital Edina Minnesota 55435
Unity Hospital Fridley Minnesota 55432
Fairview Clinics and Surgery Center Maple Grove Maple Grove Minnesota 55369
Minnesota Oncology Hematology PA-Maplewood Maplewood Minnesota 55109
Hennepin County Medical Center Minneapolis Minnesota 55415
Health Partners Inc Minneapolis Minnesota 55454
Park Nicollet Clinic - Saint Louis Park Saint Louis Park Minnesota 55416
Regions Hospital Saint Paul Minnesota 55101
United Hospital Saint Paul Minnesota 55102
Lakeview Hospital Stillwater Minnesota 55082
University of Mississippi Medical Center Jackson Mississippi 39216
Baptist Memorial Hospital and Cancer Center-Desoto Southhaven Mississippi 38671
Saint Francis Medical Center Cape Girardeau Missouri 63703
Billings Clinic Cancer Center Billings Montana 59101
Bozeman Health Deaconess Hospital Bozeman Montana 59715
Saint James Community Hospital and Cancer Treatment Center Butte Montana 59701
Benefis Sletten Cancer Institute Great Falls Montana 59405
Logan Health Medical Center Kalispell Montana 59901
Nebraska Medicine-Bellevue Bellevue Nebraska 68123
Cancer Partners of Nebraska Lincoln Nebraska 68516
Nebraska Methodist Hospital Omaha Nebraska 68114
Nebraska Medicine-Village Pointe Omaha Nebraska 68118
University of Nebraska Medical Center Omaha Nebraska 68198
Dartmouth Hitchcock Medical Center/Dartmouth Cancer Center Lebanon New Hampshire 03756
Hackensack University Medical Center Hackensack New Jersey 07601
Saint Barnabas Medical Center Livingston New Jersey 07039
Morristown Medical Center Morristown New Jersey 07960
Jersey Shore Medical Center Neptune City New Jersey 07753
Rutgers Cancer Institute of New Jersey New Brunswick New Jersey 08903
Capital Health Medical Center-Hopewell Pennington New Jersey 08534
Overlook Hospital Summit New Jersey 07902
Laura and Isaac Perlmutter Cancer Center at NYU Langone New York New York 10016
NYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer Center New York New York 10032
NYP/Weill Cornell Medical Center New York New York 10065
University of Rochester Rochester New York 14642
State University of New York Upstate Medical University Syracuse New York 13210
Good Samaritan University Hospital West Islip New York 11795
Carolinas Medical Center/Levine Cancer Institute Charlotte North Carolina 28203
Atrium Health Pineville/LCI-Pineville Charlotte North Carolina 28210
Atrium Health Cabarrus/LCI-Concord Concord North Carolina 28025
Sanford Bismarck Medical Center Bismarck North Dakota 58501
Sanford Broadway Medical Center Fargo North Dakota 58122
Sanford Roger Maris Cancer Center Fargo North Dakota 58122
Summa Health System - Akron Campus Akron Ohio 44304
Case Western Reserve University Cleveland Ohio 44106
Cleveland Clinic Foundation Cleveland Ohio 44195
Riverside Methodist Hospital Columbus Ohio 43214
Dublin Methodist Hospital Dublin Ohio 43016
Cancer Centers of Southwest Oklahoma Research Lawton Oklahoma 73505
University of Oklahoma Health Sciences Center Oklahoma City Oklahoma 73104
Clackamas Radiation Oncology Center Clackamas Oregon 97015
Providence Cancer Institute Clackamas Clinic Clackamas Oregon 97015
Legacy Mount Hood Medical Center Gresham Oregon 97030
Providence Newberg Medical Center Newberg Oregon 97132
Legacy Good Samaritan Hospital and Medical Center Portland Oregon 97210
Providence Portland Medical Center Portland Oregon 97213
Providence Saint Vincent Medical Center Portland Oregon 97225
Kaiser Permanente Northwest Portland Oregon 97227
Legacy Meridian Park Hospital Tualatin Oregon 97062
Lehigh Valley Hospital-Cedar Crest Allentown Pennsylvania 18103
Crozer-Keystone Regional Cancer Center at Broomall Broomall Pennsylvania 19008
Christiana Care Health System-Concord Health Center Chadds Ford Pennsylvania 19317
Lancaster General Ann B Barshinger Cancer Institute Lancaster Pennsylvania 17601
Lancaster General Hospital Lancaster Pennsylvania 17602
Forbes Hospital Monroeville Pennsylvania 15146
Thomas Jefferson University Hospital Philadelphia Pennsylvania 19107
Allegheny General Hospital Pittsburgh Pennsylvania 15212
University of Pittsburgh Cancer Institute (UPCI) Pittsburgh Pennsylvania 15232
UPMC-Shadyside Hospital Pittsburgh Pennsylvania 15232
Reading Hospital West Reading Pennsylvania 19611
Wexford Health and Wellness Pavilion Wexford Pennsylvania 15090
Rock Hill Radiation Therapy Center Rock Hill South Carolina 29730
Avera Cancer Institute at Pierre Pierre South Dakota 57501
Sanford Cancer Center Oncology Clinic Sioux Falls South Dakota 57104
Avera Cancer Institute Sioux Falls South Dakota 57105
Sanford USD Medical Center - Sioux Falls Sioux Falls South Dakota 57117-5134
Baptist Memorial Hospital and Cancer Center-Collierville Collierville Tennessee 38017
Baptist Memorial Hospital and Cancer Center-Memphis Memphis Tennessee 38120
Memorial Hermann Texas Medical Center Houston Texas 77030
University of Texas Health Science Center at San Antonio San Antonio Texas 78229
American Fork Hospital / Huntsman Intermountain Cancer Center American Fork Utah 84003
Sandra L Maxwell Cancer Center Cedar City Utah 84720
Logan Regional Hospital Logan Utah 84321
Intermountain Medical Center Murray Utah 84107
McKay-Dee Hospital Center Ogden Utah 84403
Utah Valley Regional Medical Center Provo Utah 84604
Riverton Hospital Riverton Utah 84065
Huntsman Cancer Institute/University of Utah Salt Lake City Utah 84112
LDS Hospital Salt Lake City Utah 84143
Saint George Regional Medical Center St. George Utah 84770
Central Vermont Medical Center/National Life Cancer Treatment Berlin Corners Vermont 05602
University of Vermont Medical Center Burlington Vermont 05401
University of Vermont and State Agricultural College Burlington Vermont 05405
Inova Schar Cancer Institute Fairfax Virginia 22031
VCU Massey Comprehensive Cancer Center Richmond Virginia 23298
VCU Community Memorial Health Center South Hill Virginia 23970
Virginia Mason Medical Center Seattle Washington 98101
Legacy Cancer Institute Medical Oncology and Day Treatment Vancouver Washington 98684
Legacy Salmon Creek Hospital Vancouver Washington 98686
Wheeling Hospital/Schiffler Cancer Center Wheeling West Virginia 26003
Aurora Cancer Care-Southern Lakes VLCC Burlington Wisconsin 53105
Aurora Health Care Germantown Health Center Germantown Wisconsin 53022
Aurora Cancer Care-Grafton Grafton Wisconsin 53024
Aurora BayCare Medical Center Green Bay Wisconsin 54311
University of Wisconsin Carbone Cancer Center - Johnson Creek Johnson Creek Wisconsin 53038
Aurora Cancer Care-Kenosha South Kenosha Wisconsin 53142
University of Wisconsin Carbone Cancer Center - University Hospital Madison Wisconsin 53792
Aurora Bay Area Medical Group-Marinette Marinette Wisconsin 54143
Aurora Cancer Care-Milwaukee Milwaukee Wisconsin 53209
Aurora Saint Luke's Medical Center Milwaukee Wisconsin 53215
Aurora Sinai Medical Center Milwaukee Wisconsin 53233
Marshfield Medical Center - Minocqua Minocqua Wisconsin 54548
Cancer Center of Western Wisconsin New Richmond Wisconsin 54017
Vince Lombardi Cancer Clinic - Oshkosh Oshkosh Wisconsin 54904
Aurora Cancer Care-Racine Racine Wisconsin 53406
Vince Lombardi Cancer Clinic-Sheboygan Sheboygan Wisconsin 53081
Aurora Medical Center in Summit Summit Wisconsin 53066
Vince Lombardi Cancer Clinic-Two Rivers Two Rivers Wisconsin 54241
Aurora Cancer Care-Milwaukee West Wauwatosa Wisconsin 53226
Aurora West Allis Medical Center West Allis Wisconsin 53227

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

About this trial record page

What this page shows
Public field values for ClinicalTrials.gov record NCT04396860, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do
No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from
Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh
Last update posted Apr 21, 2026 · Synced May 20, 2026

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Open the official record

The complete protocol, eligibility criteria, and contact information for NCT04396860 live on ClinicalTrials.gov.

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