ATHN Transcends: A Natural History Study of Non-Neoplastic Hematologic Disorders

ClinicalTrials.gov ID: NCT04398628

Public ClinicalTrials.gov record NCT04398628. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

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ClinicalTrials.gov public records Last synced Oct 16, 2026, 11:38 PM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Official title

ATHN Transcends: A Natural History Cohort Study of the Safety, Effectiveness, and Practice of Treatment in People With Non-Neoplastic Hematologic Disorders

Brief summary

Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.

In parallel with the growth of ATHN's clinical studies, the number of new therapies for all blood disorders is increasing significantly. Some of the recently FDA-approved therapies for congenital and acquired hematologic conditions have not yet demonstrated long-term safety and effectiveness beyond the pivotal trials that led to their approval. In addition, results from well controlled, pivotal studies often cannot be replicated once a therapy has been approved for general use.2,3,4,5 In 2019 alone, the FDA has issued approvals for 24 new therapies for congenital and acquired hematologic conditions.6 In addition, almost 10,000 new studies for hematologic diseases are currently registered on www.clinicaltrials.gov.7 With this increase in potential new therapies possible, it is imperative that clinicians and clinical researchers in the field of non-neoplastic hematology have a uniform, secure, unbiased, and enduring method to collect long-term safety and efficacy data. As emphasized in a recently published review, accurate, uniform and quality national data collection is critical in clinical research, particularly for longitudinal cohort studies covering a lifetime of biologic risk.8

Study identification

NCT ID: NCT04398628
Recruitment status: Recruiting
Study type: Observational
Phase: Not listed
Lead sponsor: American Thrombosis and Hemostasis Network; Network
Enrollment: 3,000 participants

Conditions and interventions

Conditions

Interventions

Not listed

Eligibility (public fields only)

Age range: Not listed
Sex: All
Healthy volunteers: Healthy volunteers not accepted

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date: Sep 30, 2020 (Actual)
Primary completion: Jun 2035 (Estimated)
Completion: Dec 2035 (Estimated)
Last update posted: Aug 17, 2026

2020 – 2035

United States locations

U.S. sites: 76
U.S. states: 31
U.S. cities: 63

Facility	City	State	ZIP	Site status
Arizona Hemophilia and Thrombosis Treatment Center at Phoenix Children's Hospital	Phoenix	Arizona	85016	Recruiting
Arkansas Center for Bleeding Disorders	Little Rock	Arkansas	72202	Recruiting
Orthopaedic Institute for Children HTC	Los Angeles	California	90007	Recruiting
Childrens Hospital Los Angeles	Los Angeles	California	90027-6016	Recruiting
UCSF Benioff Children's Hospital Oakland	Oakland	California	94610	Recruiting
University of California at Davis Hemophilia Treatment Center	Sacramento	California	95817	Recruiting
Loma Linda Hemoglobinopathy and Inherited Bleeding Disorder Program	San Bernardino	California	92408	Recruiting
Hemophilia & Thrombosis Treatment Center at UC San Diego Health	San Diego	California	92121	Recruiting
Rady Children's Hospital San Diego	San Diego	California	92123	Recruiting
University of California, San Francisco Hemophilia & Thrombosis Center	San Francisco	California	94143	Recruiting
Connecticut Children's Medical Center	Hartford	Connecticut	06106	Recruiting
Yale Hemophilia Treatment Center	New Haven	Connecticut	06520	Recruiting
Delaware Hemophilia Treatment Center	Wilmington	Delaware	19801	Recruiting
Georgetown University	Washington D.C.	District of Columbia	20007	Recruiting
Children's National Hemophilia Center	Washington D.C.	District of Columbia	20010	Recruiting
University of Florida Hemophilia Treatment Center	Gainesville	Florida	32610	Recruiting
University of Miami Comprehensive Hemophilia Treatment Center	Miami	Florida	33136	Recruiting
University of Miami Hospital and Clinics	Miami	Florida	33136	Recruiting
Arnold Palmer Hospital for Children - The Haley Center for Children's Cancer and Blood Disorders	Orlando	Florida	32806	Not yet recruiting
Johns Hopkins All Children's Hospital	St. Petersburg	Florida	33701	Recruiting
St. Joseph's Hospital Center for Bleeding & Clotting Disorders	Tampa	Florida	33607	Recruiting
University of South Florida - Adult	Tampa	Florida	33612	Recruiting
Comprehensive Bleeding Disorders Center at Emory University and Children's Healthcare of Atlanta	Atlanta	Georgia	30308	Recruiting
Emory/Children's Health Care of Atlanta	Atlanta	Georgia	30322	Recruiting
Memorial Health University Medical Center	Savannah	Georgia	31403	Recruiting
Rush University Medical Center	Chicago	Illinois	60612	Recruiting
Bleeding and Clotting Disorders Institute	Peoria	Illinois	61664	Recruiting
Indiana Hemophilia and Thrombosis Center	Indianapolis	Indiana	46260	Recruiting
Iowa Hemophilia and Thrombosis Center	Iowa City	Iowa	52242	Recruiting
Louisiana Center for Bleeding and Clotting Disorders, Tulane University	New Orleans	Louisiana	70112	Recruiting
Maine Hemophilia and Thrombosis Center	Scarborough	Maine	04074	Recruiting
Johns Hopkins University Hemophilia Treatment Center	Baltimore	Maryland	21287	Recruiting
Massachusetts General Hospital Comprehensive Hemophilia and Thrombosis Treatment Center	Boston	Massachusetts	02114	Not yet recruiting
Central Michigan Children's Hospital of Michigan	Detroit	Michigan	48201	Recruiting
Henry Ford Health System Bleeding and Thrombosis Treatment Center	Detroit	Michigan	48202	Recruiting
Mayo Comprehensive Hemophilia Center	Rochester	Minnesota	55905	Recruiting
Children's Mercy Hospital - Kansas City	Kansas City	Missouri	64108	Recruiting
The John Bouhasin Center for Children with Bleeding Disorders	St Louis	Missouri	63104	Recruiting
Cure 4 The Kids Foundation	Las Vegas	Nevada	89135	Recruiting
Hemostasis and Thrombosis Center of Nevada	Reno	Nevada	89509	Recruiting
Newark Beth Israel Medical Center - Hemophilia Center	Newark	New Jersey	07122	Recruiting
University of New Mexico Ted R. Montoya Hemophilia & Thrombosis Program	Albuquerque	New Mexico	87131	Recruiting
Western New York BloodCare	Buffalo	New York	14202	Recruiting
Northwell Health Hemostasis and Thrombosis Center at Long Island Jewish and Cohen Children's Medical Center	Hyde Park	New York	11040	Recruiting
Weill Cornell Medical College - New York Presbyterian Hospital	New York	New York	10065	Recruiting
American Thrombosis and Hemostasis Network	Rochester	New York	14626	Recruiting
Montefiore Medical Center	The Bronx	New York	10461	Recruiting
Comprehensive Hemophilia Treatment Center, University of North Carolina at Chapel Hill	Chapel Hill	North Carolina	27517	Recruiting
St. Jude Affiliate Clinic at Novant Health Hemby Children's Hospital	Charlotte	North Carolina	28204	Recruiting
East Carolina University Hemophilia Treatment Center	Greenville	North Carolina	27834	Recruiting
Wake Forest University Health Sciences	Winston-Salem	North Carolina	27157	Recruiting
Akron Children's Hospital - Showers Center for Cancer & Blood Disorders	Akron	Ohio	44308	Recruiting
Cincinnati Children's Hospital Medical Center, Hemophilia & Thrombosis Center	Cincinnati	Ohio	45229	Recruiting
University of Cincinnati Medical Center Hemophilia Treatment Center	Cincinnati	Ohio	45267	Recruiting
University Hospitals Health System Cleveland	Cleveland	Ohio	44106	Recruiting
Ohio State University Medical Center	Columbus	Ohio	43203	Recruiting
Nationwide Children's Hospital Columbus	Columbus	Ohio	43205	Recruiting
Dayton Children's Hemostasis and Thrombosis Center	Dayton	Ohio	45404	Recruiting
Northwest Ohio Hemophilia Treatment Center at the Toledo Hospital	Toledo	Ohio	43606	Recruiting
Children's Hospital of Philadelphia	Philadelphia	Pennsylvania	19104	Recruiting
Penn Comprehensive Hemophilia and Thrombophilia Program/Hospital of the University of Pennsylvania	Philadelphia	Pennsylvania	19104	Recruiting
St. Christopher's Hospital for Children	Philadelphia	Pennsylvania	19134	Recruiting
Hemophilia Center of Western Pennsylvania	Pittsburgh	Pennsylvania	15213	Recruiting
Rhode Island Hospital Hemostasis and Thrombosis Center	Providence	Rhode Island	02903	Recruiting
St. Jude Children's Research Hospital	Memphis	Tennessee	38105	Recruiting
Vanderbilt University Medical Center	Nashville	Tennessee	37212	Recruiting
Children's Blood and Cancer Center of Central Texas	Austin	Texas	78723	Recruiting
North Texas Hemophilia and Thrombosis Program - Pediatric Program / Center for Cancer & Blood Disorders	Dallas	Texas	75235	Recruiting
North Texas Comprehensive Hemophilia Treatment Center	Dallas	Texas	75390	Recruiting
Gulf States Hemophilia and Thrombophilia Center	Houston	Texas	77030	Recruiting
Texas Children's Hemophilia & Thrombosis Center/Baylor College of Medicine	Houston	Texas	77030	Recruiting
South Texas Comprehensive Hemophilia and Thrombophilia Treatment Center	San Antonio	Texas	78229	Recruiting
Children's Hospital of Kings Daughters	Norfolk	Virginia	23507	Recruiting
Washington Center for Bleeding Disorders	Seattle	Washington	98101	Recruiting
Hemophilia Outreach Center Green Bay	Green Bay	Wisconsin	54311	Recruiting
Comprehensive Center for Bleeding Disorders	Milwaukee	Wisconsin	53226	Recruiting

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

About this trial record page

What this page shows: Public field values for ClinicalTrials.gov record NCT04398628, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do: No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from: Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh: Last update posted Aug 17, 2026 · Synced Oct 16, 2026

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The complete public registry record, listed eligibility criteria, and available contact information for NCT04398628 live on ClinicalTrials.gov.

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