Study to Compare Adjuvant Immunotherapy of Bempegaldesleukin Combined With Nivolumab Versus Nivolumab After Complete Resection of Melanoma in Patients at High Risk for Recurrence
Public ClinicalTrials.gov record NCT04410445. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase 3, Randomized, Open-label Study to Compare Adjuvant Immunotherapy of Bempegaldesleukin Combined With Nivolumab Versus Nivolumab After Complete Resection of Melanoma in Patients at High Risk for Recurrence (PIVOT-12)
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
The main purpose of this study is to compare the efficacy of bempegaldesleukin plus nivolumab versus nivolumab in patients with completely resected Stage IIIA/B/C/D, or Stage IV cutaneous melanoma who are at high risk for recurrence.
Study identification
- NCT ID
- NCT04410445
- Recruitment status
- Terminated
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 765 participants
Conditions and interventions
Eligibility (public fields only)
- Age range
- 12 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Jul 27, 2020 (Actual)
- Primary completion
- Sep 22, 2022 (Actual)
- Completion
- Sep 22, 2022 (Actual)
- Last update posted
- Apr 21, 2023
2020 – 2022
United States locations
- U.S. sites
- 62
- U.S. states
- 28
- U.S. cities
- 47
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Honor Health | Scottsdale | Arizona | 85258 | — |
| Banner MD Anderson Cancer Center | Little Rock | Arkansas | 72205 | — |
| Kaiser Foundation Hospital, Inpatient Pharmacy | Anaheim | California | 92805 | — |
| Kaiser Permanente | Fontana | California | 92335 | — |
| St. Joseph Heritage Healthcare | Fullerton | California | 92835 | — |
| Hematology Oncology Medical Group of Orange County, Inc. | Orange | California | 92868 | — |
| University of California Irvine | Orange | California | 92868 | — |
| Emad Ibrahim, MD, Inc | Redlands | California | 92373 | — |
| Kaiser Permanente | Riverside | California | 92505 | — |
| Southern California Permanente Medical Group | Riverside | California | 92505 | — |
| San Francisco Oncology Associates | San Francisco | California | 94115 | — |
| California Cancer Associates for Research and Excellence | San Marcos | California | 92069 | — |
| Kaiser Permanente | San Marcos | California | 92078 | — |
| Angeles Clinic and Research Institute | Santa Monica | California | 90404 | — |
| John Wayne Cancer Institute | Santa Monica | California | 90404 | — |
| Rocky Mountain Cancer Centers (Littleton) - USOR | Aurora | Colorado | 80012 | — |
| University of Colorado - Cancer Center - PPDS | Aurora | Colorado | 80045 | — |
| MedStar Georgetown University Hospital | Washington D.C. | District of Columbia | 20007 | — |
| Orlando Health Cancer Institute | Longwood | Florida | 32750 | — |
| Rush University Medical Center | Chicago | Illinois | 60612 | — |
| Goshen Center For Cancer Care | Goshen | Indiana | 46526 | — |
| University of Kentucky | Lexington | Kentucky | 40536 | — |
| Ochsner Clinic Foundation | New Orleans | Louisiana | 70121 | — |
| Massachusetts General Hospital | Boston | Massachusetts | 02114 | — |
| Mayo Clinic - PIN | Rochester | Minnesota | 55905 | — |
| Washington University School of Medicine | St Louis | Missouri | 63110 | — |
| Frontier Cancer Center and Blood Institute | Billings | Montana | 59102 | — |
| Nebraska Cancer Specialists | Omaha | Nebraska | 68130 | — |
| Nebraska Methodist Hospital | Omaha | Nebraska | 68130 | — |
| University of Nebraska Medical Center | Omaha | Nebraska | 68198 | — |
| Hackensack University Medical Center | Hackensack | New Jersey | 07601 | — |
| Atlantic Health System | Morristown | New Jersey | 07960 | — |
| NYU Langone Medical Center | New York | New York | 10016 | — |
| Columbia University Medical Center - PIN | New York | New York | 10021 | — |
| Icahn School of Medicine at Mount Sinai | New York | New York | 10029 | — |
| University of North Carolina at Chapel Hill | Chapel Hill | North Carolina | 32750 | — |
| Duke Cancer Institute | Durham | North Carolina | 27710 | — |
| University Hospitals Cleveland Medical Center | Cleveland | Ohio | 44106 | — |
| The Cleveland Clinic Foundation | Cleveland | Ohio | 44195 | — |
| Providence Cancer Institute, Franz Clinic | Portland | Oregon | 97213 | — |
| Oregon Health and Science University | Portland | Oregon | 97216 | — |
| Lehigh Valley Physician Group (LVPG) - Hematology Oncology | Allentown | Pennsylvania | 18103 | — |
| Penn State Milton S Hershey Medical Center | Hershey | Pennsylvania | 17033 | — |
| Jefferson University Hospital | Philadelphia | Pennsylvania | 19107 | — |
| H Lee Moffitt Cancer Center and Research Institute | Pittsburgh | Pennsylvania | 15232 | — |
| Hillman Cancer Center | Pittsburgh | Pennsylvania | 15232 | — |
| Prisma Health Cancer Institute | Greenville | South Carolina | 29605 | — |
| SCRI Tennessee Oncology Chattanooga | Chattanooga | Tennessee | 37404 | — |
| University of Tennessee Medical Center | Knoxville | Tennessee | 37920 | — |
| SCRI Tennessee Oncology Nashville | Nashville | Tennessee | 37203 | — |
| Vanderbilt University Medical Center | Nashville | Tennessee | 37232 | — |
| Department of Pharmacy Investigational Drug Services | Dallas | Texas | 75235 | — |
| Texas Oncology (Loop) - USOR | Dallas | Texas | 75246 | — |
| University of Texas Southwestern Medical Center | Dallas | Texas | 75390 | — |
| MD Anderson Cancer Center | Houston | Texas | 77030 | — |
| Utah Cancer Specialists (Salt Lake City) | Salt Lake City | Utah | 90603 | — |
| University of Virginia Cancer Center | Charlottesville | Virginia | 22903 | — |
| Inova Schar Cancer Institute | Fairfax | Virginia | 22031 | — |
| Blue Ridge Cancer Care - USOR | Roanoke | Virginia | 24014 | — |
| Seattle Cancer Care Alliance | Seattle | Washington | 98109 | — |
| Northwest Medical Specialties | Tacoma | Washington | 98405 | — |
| University of Wisconsin | Madison | Wisconsin | 53792 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 150 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT04410445, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Apr 21, 2023 · Synced Oct 25, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT04410445 live on ClinicalTrials.gov.