ADVM-022 Intravitreal Gene Therapy for DME
Public ClinicalTrials.gov record NCT04418427. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase 2, Multi-Center, Randomized, Double-Masked, Active Controlled Study of ADVM-022 (AAV.7m8-aflibercept) in Subjects With Diabetic Macular Edema [INFINITY]
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
A Phase 2, Multi-Center, Randomized, Double-Masked\*, Active Controlled Study of ADVM-022 (AAV.7m8-aflibercept) in Subjects with Diabetic Macular Edema \[INFINITY\]
Study identification
- NCT ID
- NCT04418427
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 2
- Enrollment
- 36 participants
Conditions and interventions
Conditions
Interventions
- 6E11 vg/eye of ADVM-022 Biological
- 2E11 vg/eye of ADVM-022 Biological
- Aflibercept Biological
Biological
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- May 28, 2020 (Actual)
- Primary completion
- Nov 22, 2022 (Actual)
- Completion
- Jun 14, 2023 (Actual)
- Last update posted
- Jul 10, 2025
2020 – 2023
United States locations
- U.S. sites
- 13
- U.S. states
- 9
- U.S. cities
- 13
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Adverum Clinical Site | Phoenix | Arizona | 85014 | — |
| Adverum Clinical Site | Bakersfield | California | 93309 | — |
| Adverum Clinical Site | Beverly Hills | California | 90211 | — |
| Adverum Clinical Site | Golden | Colorado | 80401 | — |
| Adverum Clinical Site | Deerfield Beach | Florida | 33064 | — |
| Adverum Clinical Site | Reno | Nevada | 89502 | — |
| Adverum Clinical Site | Philadelphia | Pennsylvania | 19107 | — |
| Adverum Clinical Site | West Columbia | South Carolina | 29169 | — |
| Adverum Clinical Site | Nashville | Tennessee | 37203 | — |
| Adverum Clinical Site | Abilene | Texas | 79606 | — |
| Adverum Clinical Site | Austin | Texas | 78705 | — |
| Adverum Clinical Site | Houston | Texas | 77030 | — |
| Adverum Clinical Site | The Woodlands | Texas | 77384 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 1 non-U.S. site.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT04418427, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Jul 10, 2025 · Synced Oct 22, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT04418427 live on ClinicalTrials.gov.