Study of the Effects of High Dose Aflibercept Injected Into the Eye of Patients With an Age-related Disorder That Causes Loss of Vision Due to Growth of Abnormal Blood Vessels at the Back of the Eye
Public ClinicalTrials.gov record NCT04423718. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
Randomized, Double-Masked, Active-Controlled, Phase 3 Study of the Efficacy and Safety of High Dose Aflibercept in Patients With Neovascular Age-Related Macular Degeneration
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
In this study researchers want to learn more about changes in visual acuity (clarity of vision) with a high dose treatment with Aflibercept (Eylea) in patients suffering from neovascular age-related macular degeneration (nAMD). Neovascular AMD is an eye disease that causes blurred vision or a blind spot due to abnormal blood vessels that leak fluid or blood into the light sensitive lining inside the eye (retina). The fluid buildup causes the central part of the retina (macula) responsible for sharp, straight-ahead vision to swell and thicken (edema), which distorts vision.
Study identification
- NCT ID
- NCT04423718
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 1,011 participants
Conditions and interventions
Conditions
Interventions
- Aflibercept High Dose VEGF Trap-Eye (BAY86-5321) Drug
- Aflibercept VEGF Trap-Eye (Eylea, BAY86-5321) Drug
Drug
Eligibility (public fields only)
- Age range
- 50 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Aug 11, 2020 (Actual)
- Primary completion
- Jul 27, 2022 (Actual)
- Completion
- Aug 7, 2024 (Actual)
- Last update posted
- Aug 29, 2025
2020 – 2024
United States locations
- U.S. sites
- 57
- U.S. states
- 27
- U.S. cities
- 55
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Arizona Retina & Vitreous Consultants - Central Phoenix Phoenix | Phoenix | Arizona | 85021-8865 | — |
| Retina Consultants of Orange County - Fullerton | Fullerton | California | 92835 | — |
| Northern California Retina Vitreous Associates - Mountain View Office | Mountain View | California | 94040 | — |
| Azul Vision Pasadena | Pasadena | California | 91107 | — |
| Retina Consultants San Diego - Poway | Poway | California | 92064 | — |
| Retina Consultants of Southern California | Redlands | California | 92374 | — |
| Kaiser Permanente Riverside Medical Center - Cardiology | Riverside | California | 92505 | — |
| Perlman Medical Offices at UC San Diego Health - Endocrinology | San Diego | California | 92037 | — |
| Retina Consultants of Southern Colorado, PC | Colorado Springs | Colorado | 80909 | — |
| New England Retina Associates | New London | Connecticut | 06320 | — |
| Rand Eye Institute | Deerfield Beach | Florida | 33064 | — |
| Retina Group of Florida - Fort Lauderdale | Fort Lauderdale | Florida | 33308 | — |
| Vitreo Retinal Associates PA - The Millennium Center Location | Gainesville | Florida | 32607-2557 | — |
| Florida Retina Institute- Jacksonville Oak | Jacksonville | Florida | 32204 | — |
| Florida Eye Associates - Melbourne Main Office | Melbourne | Florida | 32901 | — |
| Retina Macula Specialists Of Miami - LeJeune Road Office | Miami | Florida | 33126 | — |
| Florida Retina Institute - Orlando | Orlando | Florida | 32806 | — |
| Retina Specialty Institute - Pensacola | Pensacola | Florida | 32503 | — |
| Retina Vitreous Associates of Florida - Saint Petersburg | St. Petersburg | Florida | 33711 | — |
| Southern Vitreoretinal Associates, P.L. - Tallahassee | Tallahassee | Florida | 32308 | — |
| Retina Consultants of Hawaii - Pali Momi Medical Center | ‘Aiea | Hawaii | 96701 | — |
| Retina Associates IL | Elmhurst | Illinois | 60126 | — |
| University Retina and Macula Associates | Oak Forest | Illinois | 60452 | — |
| Wolfe Eye Clinic - Des Moines | West Des Moines | Iowa | 50266-7705 | — |
| The Retina Care Center - Baltimore | Baltimore | Maryland | 21209 | — |
| Ophthalmic Consultants of Boston - Boston | Boston | Massachusetts | 02114 | — |
| Vitreo Retinal Surgery PA - Edina | Edina | Minnesota | 55435 | — |
| Retina Consultants of Nevada - Summerlin | Las Vegas | Nevada | 89144 | — |
| Retina Center of New Jersey | Bloomfield | New Jersey | 07003 | — |
| NJ Retina - Edison Office | Edison | New Jersey | 08820 | — |
| Eye Associates of New Mexico - Albuquerque - Retina Center | Albuquerque | New Mexico | 87109 | — |
| Long Island Vitreoretinal Consultants - Great Neck | Great Neck | New York | 11021 | — |
| Vitreoretinal Consultants of NY - Hauppauge | Hauppauge | New York | 11788 | — |
| Ophthalmic Consultants of Long Island | Lynbrook | New York | 11563 | — |
| Ophthalmic Consultants of the Capital Region - Troy | Troy | New York | 12180 | — |
| Wake Forest Baptist Health | Winston-Salem | North Carolina | 27157 | — |
| Midwest Retina - Main Office | Dublin | Ohio | 43016 | — |
| Retina Northwest - NW Lovejoy | Portland | Oregon | 97210 | — |
| Retina Consultants, LLC | Salem | Oregon | 97302 | — |
| Mid Atlantic Retina - Philadelphia / Wills Eye Hospital | Bethlehem | Pennsylvania | 18017 | — |
| Erie Retinal Research | Erie | Pennsylvania | 16507 | — |
| Eye Care Specialists - Kingston, PA | Kingston | Pennsylvania | 18704 | — |
| Charleston Neuroscience Institute - Charleston | Charleston | South Carolina | 29414 | — |
| Palmetto Retina Center - West Columbia | West Columbia | South Carolina | 29169 | — |
| Black Hills Regional Eye Institute | Rapid City | South Dakota | 57701 | — |
| Charles Retina Specialists - Germantown | Memphis | Tennessee | 38119 | — |
| Vanderbilt University Medical School | Nashville | Tennessee | 37212-1610 | — |
| Austin Retina Associates - Central | Austin | Texas | 78705 | — |
| Texas Retina Associates - Fort Worth | Fort Worth | Texas | 76104 | — |
| Medical Center Ophthalmology Associates - Northwest | San Antonio | Texas | 78240 | — |
| Retina Consultants of Texas - San Antonio Medical Center | San Antonio | Texas | 78240 | — |
| Retina Consultants of Texas (Retina Consultants of Houston) - Texas Medical Center | The Woodlands | Texas | 77384 | — |
| Retina Consultants of Texas - The Woodlands | The Woodlands | Texas | 77384 | — |
| The University of Vermont Medical Center (Fletcher Allen Health Care) - Main Campus | Burlington | Vermont | 05401-1473 | — |
| Spokane Eye Clinical Research | Spokane | Washington | 99204 | — |
| West Virginia University | Morgantown | West Virginia | 26505 | — |
| University of Wisconsin - Madison | Madison | Wisconsin | 53792 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 178 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT04423718, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Aug 29, 2025 · Synced Oct 19, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT04423718 live on ClinicalTrials.gov.