Safety, Tolerability, and Efficacy of Anti-Spike (S) SARS-CoV-2 Monoclonal Antibodies for Hospitalized Adult Patients With COVID-19
Public ClinicalTrials.gov record NCT04426695. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Master Protocol Assessing the Safety, Tolerability, and Efficacy of Anti-Spike (S) SARS-CoV-2 Monoclonal Antibodies for the Treatment of Hospitalized Patients With COVID-19
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
The primary objectives are: Pooled Phase 3 (Cohort 1) and Phase 2 (Cohort 1A) * To evaluate the virologic efficacy of REGN10933+REGN10987 compared to placebo in reducing viral load of SARS-CoV-2 * To evaluate the clinical efficacy of REGN10933+REGN10987 compared to placebo, as measured by death or mechanical ventilation Phase 1/2 (Cohort 1) * To exclude futility of REGN10933+REGN10987 compared to placebo, as measured by death or mechanical ventilation * To evaluate the safety and tolerability of REGN10933+REGN10987 compared to placebo
Study identification
- NCT ID
- NCT04426695
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 1, Phase 2
- Enrollment
- 2,252 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Jun 10, 2020 (Actual)
- Primary completion
- May 7, 2021 (Actual)
- Completion
- Oct 22, 2021 (Actual)
- Last update posted
- Jan 27, 2023
2020 – 2021
United States locations
- U.S. sites
- 96
- U.S. states
- 32
- U.S. cities
- 73
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Regeneron Study Site | Birmingham | Alabama | 35249 | — |
| Regeneron Study Site | Chandler | Arizona | 85224 | — |
| Regeneron Study Site | Phoenix | Arizona | 85006 | — |
| Regeneron Study Site 1 | Tucson | Arizona | 85724 | — |
| Regeneron Study Site | Long Beach | California | 90806 | — |
| Regeneron Study Site | Mission Hills | California | 91345 | — |
| Regeneron Study Site | Sacramento | California | 95817 | — |
| Regeneron Study Site | Santa Monica | California | 90404 | — |
| Regeneron Study Site | Stanford | California | 94305 | — |
| Regeneron Study Site | Aurora | Colorado | 80045 | — |
| Regeneron Study Site | Boca Raton | Florida | 33486 | — |
| Regeneron Study Site | Ft. Pierce | Florida | 34982 | — |
| Regeneron Study Site | Gainesville | Florida | 32610 | — |
| Regeneron Study Site | Orlando | Florida | 32803 | — |
| Regeneron Study Site | Pensacola | Florida | 32504 | — |
| Regeneron Study Site | Sarasota | Florida | 34239 | — |
| Regeneron Study Site | Tampa | Florida | 33612 | — |
| Regeneron Study Site | Atlanta | Georgia | 30309 | — |
| Regeneron Study Site | Atlanta | Georgia | 30322 | — |
| Regeneron Study Site | Augusta | Georgia | 30912 | — |
| Regeneron Study Site | Marietta | Georgia | 30060 | — |
| Regeneron Study Site | Chicago | Illinois | 60611 | — |
| Regeneron Study Site | Chicago | Illinois | 60612 | — |
| Regeneron Study Site | Glenview | Illinois | 60026 | — |
| Regeneron Study Site | Urbana | Illinois | 61801 | — |
| Regeneron Study Site | Indianapolis | Indiana | 46260 | — |
| Regeneron Study Site | Iowa City | Iowa | 52242 | — |
| Regeneron Study Site | Louisville | Kentucky | 40202 | — |
| Regeneron Study Site | Louisville | Kentucky | 40217 | — |
| Regeneron Study Site | New Orleans | Louisiana | 70112 | — |
| Regeneron Study Site | New Orleans | Louisiana | 70122 | — |
| Regeneron Study Site | Baltimore | Maryland | 21201 | — |
| Regeneron Study Site | Boston | Massachusetts | 02111 | — |
| Regeneron Study Site | Boston | Massachusetts | 02115 | — |
| Regeneron Study Site | Boston | Massachusetts | 02118 | — |
| Regeneron Study Site | Grand Rapids | Michigan | 49503 | — |
| Regeneron Study Site | Royal Oak | Michigan | 48073 | — |
| Regeneron Study Site | Rochester | Minnesota | 55905 | — |
| Regeneron Study Site | Chesterfield | Missouri | 63017 | — |
| Regeneron Study Site | St Louis | Missouri | 63104 | — |
| Regeneron Study Site | St Louis | Missouri | 63110 | — |
| Regeneron Study Site | Omaha | Nebraska | 68198-5400 | — |
| Regeneron Study Site | Las Vegas | Nevada | 89109 | — |
| Regeneron Study Site | Englewood | New Jersey | 07631 | — |
| Regeneron Study Site | Hackensack | New Jersey | 07601 | — |
| Regeneron Study Site | Morristown | New Jersey | 07960 | — |
| Regeneron Study Site | Neptune City | New Jersey | 07753 | — |
| Regeneron Study Site | Pennington | New Jersey | 08534 | — |
| Regeneron Study Site | Summit | New Jersey | 07901 | — |
| Regeneron Study Site | Teaneck | New Jersey | 07666 | — |
| Regeneron Study Site | Albuquerque | New Mexico | 87108 | — |
| Regeneron Study Site | Brooklyn | New York | 11219 | — |
| Regeneron Study Site | Buffalo | New York | 14203 | — |
| Regeneron Study Site 1 | Buffalo | New York | 14215 | — |
| Regeneron Study Site 2 | Buffalo | New York | 14215 | — |
| Regeneron Study Site | Jamaica | New York | 11432 | — |
| Regeneron Study Site | New York | New York | 10003 | — |
| Regeneron Study Site | New York | New York | 10019 | — |
| Regeneron Study Site | New York | New York | 10025 | — |
| Regeneron Study Site | New York | New York | 10029 | — |
| Regeneron Study Site | New York | New York | 10032 | — |
| Regeneron Study Site | New York | New York | 10037 | — |
| Regeneron Study Site | Rochester | New York | 14642 | — |
| Regeneron Study Site | Syracuse | New York | 13210 | — |
| Regeneron Study Site | The Bronx | New York | 10451 | — |
| Regeneron Study Site | The Bronx | New York | 10461 | — |
| Regeneron Study Site | West Islip | New York | 11795 | — |
| Regeneron Study Site | White Plains | New York | 10601 | — |
| Regeneron Study Site | Chapel Hill | North Carolina | 27599 | — |
| Regeneron Study Site | Greensboro | North Carolina | 27408 | — |
| Regeneron Study Site | Columbus | Ohio | 43210 | — |
| Regeneron Study Site | Columbus | Ohio | 43215 | — |
| Regeneron Study Site | Dayton | Ohio | 45409 | — |
| Regeneron Study Site | Portland | Oregon | 97213 | — |
| Regeneron Study Site | Portland | Oregon | 97239 | — |
| Regeneron Study Site | Philadelphia | Pennsylvania | 19140 | — |
| Regeneron Study Site | Providence | Rhode Island | 02903 | — |
| Regeneron Study Site | Providence | Rhode Island | 02906 | — |
| Regeneron Study Site | Sioux Falls | South Dakota | 57108 | — |
| Regeneron Study Site 1 | Amarillo | Texas | 79106 | — |
| Regeneron Study Site 2 | Amarillo | Texas | 79106 | — |
| Regeneron Study Site | Dallas | Texas | 75235 | — |
| Regeneron Study Site | Dallas | Texas | 75246 | — |
| Regeneron Study Site | Dallas | Texas | 75390 | — |
| Regeneron Study Site | Houston | Texas | 77004 | — |
| Regeneron Study Site | Houston | Texas | 77024 | — |
| Regeneron Study Site | Houston | Texas | 77030 | — |
| Regeneron Study Site | Lubbock | Texas | 79410 | — |
| Regeneron Study Site | Sugar Land | Texas | 77479 | — |
| Regeneron Study Site | Tyler | Texas | 75701 | — |
| Regeneron Study Site | Murray | Utah | 84107 | — |
| Regeneron Study Site | Salt Lake City | Utah | 84143 | — |
| Regeneron Study Site | Richmond | Virginia | 23298 | — |
| Regeneron Study Site | Everett | Washington | 98201 | — |
| Regeneron Study Site 1 | Seattle | Washington | 98122 | — |
| Regeneron Study Site | Madison | Wisconsin | 53792 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 27 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT04426695, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Jan 27, 2023 · Synced Oct 22, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT04426695 live on ClinicalTrials.gov.