ClinicalTrials.gov record
A Phase 3 Safety and Efficacy Study of Intravitreal Administration of Zimura (Complement C5 Inhibitor)
ClinicalTrials.gov ID: NCT04435366
Public ClinicalTrials.gov record NCT04435366. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase 3 Multicenter, Randomized, Double Masked, Sham- Controlled Clinical Trial to Assess the Safety and Efficacy of Intravitreal Administration of Zimura (Complement C5 Inhibitor) in Patients With Geographic Atrophy Secondary to Age-Related Macular Degeneration
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
The objectives of this study was to evaluate the safety and efficacy of avacincaptad pegol intravitreal administration in participants with geographic atrophy secondary to age-related macular degeneration (AMD)
Study identification
- NCT ID
- NCT04435366
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 448 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 50 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Jun 21, 2020
- Primary completion
- Jul 24, 2022
- Completion
- Aug 21, 2023
- Last update posted
- Oct 20, 2025
2020 – 2023
United States locations
- U.S. sites
- 96
- U.S. states
- 30
- U.S. cities
- 89
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Retina-Vitreous Associates Medical Group | Beverly Hills | California | 90211 | — |
| Retinal Diagnostic Center | Campbell | California | 95008 | — |
| Eye Medical Center of Fresno | Fresno | California | 93720 | — |
| Retina Consultants of Orange County | Fullerton | California | 92835 | — |
| University of California, San Diego | La Jolla | California | 92093 | — |
| Jules Stein Eye Institute/David Geffen School of Medicine | Los Angeles | California | 90095 | — |
| Northern California Retina Vitreous Associates | Mountain View | California | 94040 | — |
| California Retina Consultants | Oxnard | California | 93036 | — |
| Southern California Desert Retina Consultants | Palm Desert | California | 92211 | — |
| Doheny Eye Center, UCLA | Pasadena | California | 91105 | — |
| Retina Consultants of Southern California | Redlands | California | 92374 | — |
| Retinal Consultants Medical Group, Inc. | Sacramento | California | 95825 | — |
| Orange County Retinal Medical Group | Santa Ana | California | 92705 | — |
| University of Colorado | Aurora | Colorado | 80045 | — |
| Retina Consultants of Southern Colorado, P.C. | Colorado Springs | Colorado | 80909 | — |
| Colorado Retina Associates | Lakewood | Colorado | 80228 | — |
| Connecticut Eye Consultants, P.C. | Danbury | Connecticut | 06810 | — |
| Retina Group of New England, PC | Waterford | Connecticut | 06385 | — |
| Florida Eye Clinic | Altamonte Springs | Florida | 32701 | — |
| Rand Eye Institute | Deerfield Beach | Florida | 33064 | — |
| Retina Group of Florida | Fort Lauderdale | Florida | 33308 | — |
| Retina Health Center | Fort Myers | Florida | 33907 | — |
| National Ophthalmic Research Institute | Fort Myers | Florida | 33912 | — |
| VitreoRetinal Associates, P.A. | Gainesville | Florida | 32607 | — |
| Florida Eye Associates | Melbourne | Florida | 32901 | — |
| University of Miami-Bascom Palmer Eye Institute | Miami | Florida | 33136 | — |
| Retina Care Specialists | Palm Beach Gardens | Florida | 33410 | — |
| Retina Specialty Institute | Pensacola | Florida | 32503 | — |
| Retina Associates of Sarasota | Sarasota | Florida | 34233 | — |
| Retina Vitreous Associates of Florida | St. Petersburg | Florida | 33711 | — |
| East Florida Eye Institute | Stuart | Florida | 34994 | — |
| Southern Vitreoretinal Associates, PL | Tallahassee | Florida | 32308 | — |
| Center for Retina and Macula Disease | Winter Haven | Florida | 33880 | — |
| Southeast Retina Center | Augusta | Georgia | 30909 | — |
| Georgia Retina, P.C. | Marietta | Georgia | 30060 | — |
| Retina Consultants of Hawaii, Inc | ‘Aiea | Hawaii | 96701 | — |
| University Retina and Macula Associates, PC | Lemont | Illinois | 60439 | — |
| Illinois Eye Center | Peoria | Illinois | 61615 | — |
| Midwest Eye Institute | Indianapolis | Indiana | 46290 | — |
| Wolfe Eye Clinic | West Des Moines | Iowa | 50266 | — |
| Retina Associates, LLC | Lenexa | Kansas | 66215 | — |
| Vitreo Retinal Consultants & Surgeons | Wichita | Kansas | 67214 | — |
| Ochsner Medical Center | New Orleans | Louisiana | 70121 | — |
| The Retina Care Center | Baltimore | Maryland | 21209 | — |
| The Retina Group of Washington | Chevy Chase | Maryland | 20815 | — |
| Cumberland Valley Retina Consultants | Hagerstown | Maryland | 21740 | — |
| Ophthalmic Consultants of Boston | Boston | Massachusetts | 02114 | — |
| Retina Research Institute at New England Retinal Consultants | Springfield | Massachusetts | 01107 | — |
| UMASS Memorial Eye Center | Worcester | Massachusetts | 01605 | — |
| Vitreoretinal Associates, PC | Worcester | Massachusetts | 01605 | — |
| Associated Retinal Consultants, P.C. | Royal Oak | Michigan | 48073 | — |
| Retina Center | Minneapolis | Minnesota | 55404 | — |
| St. Louis University | St Louis | Missouri | 63110 | — |
| Retina Consultants of Nevada | Henderson | Nevada | 89052 | — |
| Sierra Eye Associates | Reno | Nevada | 89502 | — |
| Retina Center of New Jersey, LLC | Bloomfield | New Jersey | 07003 | — |
| Long Island Vitreoretinal Consultant | Great Neck | New York | 11021 | — |
| Retina Vitreous Surgeons of Central New York, PC | Liverpool | New York | 13088 | — |
| Vitreous Retina Macula Consultants of New York (VRMNY) | New York | New York | 10022 | — |
| OCLI | Oceanside | New York | 11572 | — |
| Retina Associates of Western NY, PC | Rochester | New York | 14620 | — |
| Ophthalmic Consultants of the Capital Region | Troy | New York | 12180 | — |
| Western Carolina Retinal Associates | Asheville | North Carolina | 28803 | — |
| Cincinnati Eye Institute | Cincinnati | Ohio | 45242 | — |
| Retina and Vitreous Center of Southern Oregon | Ashland | Oregon | 97520 | — |
| Retina Northwest, PC | Portland | Oregon | 97221 | — |
| EyeHealth Northwest | Portland | Oregon | 97225 | — |
| Casey Eye Institute | Portland | Oregon | 97239 | — |
| Scheie Eye Institute, University of Pennsylvania | Philadelphia | Pennsylvania | 19104 | — |
| Mid Atlantic Retina | Philadelphia | Pennsylvania | 19107 | — |
| Associates in Ophthalmology, Ltd | West Mifflin | Pennsylvania | 15122 | — |
| Retina Research of Beaufort, LLC | Beaufort | South Carolina | 29902 | — |
| Charleston Neuroscience Institute | Ladson | South Carolina | 29456 | — |
| Carolina Macula and Retina | Mt. Pleasant | South Carolina | 29464 | — |
| Palmetto Retina Center | West Columbia | South Carolina | 29169 | — |
| Black Hills Regional Eye Institute | Rapid City | South Dakota | 57701 | — |
| Southeastern Retina Associates, PC | Johnson City | Tennessee | 37604 | — |
| Southeastern Retina Associates, PC | Knoxville | Tennessee | 37922 | — |
| Retina Research Institute of Texas | Abilene | Texas | 79606 | — |
| Southwest Retina Specialists | Amarillo | Texas | 79106 | — |
| Austin Retina Associates | Austin | Texas | 78705 | — |
| Retina Foundation of the Southwest | Dallas | Texas | 75231 | — |
| Retina and Vitreous of Texas, PLLC | Houston | Texas | 77025 | — |
| Valley Retina Institute | McAllen | Texas | 78503 | — |
| Medical Center Ophthalmology Associates | San Antonio | Texas | 78240 | — |
| Retina Center of Texas | Southlake | Texas | 76092 | — |
| Retinal Consultants of Houston | The Woodlands | Texas | 77384 | — |
| Strategic Clinical Research Group | Willow Park | Texas | 76087 | — |
| Retinal Associates of Utah | Salt Lake City | Utah | 84107 | — |
| Rocky Mountain Retina Consultants | Salt Lake City | Utah | 84107 | — |
| University of Utah, John A. Moran Eye Center | Salt Lake City | Utah | 84132 | — |
| Wagner Macular & Retina Center | Norfolk | Virginia | 23502 | — |
| Retina Institute of Virginia | Richmond | Virginia | 23235 | — |
| Vistar Eye Center | Roanoke | Virginia | 24018 | — |
| Pacific Northwest Retina | Bellevue | Washington | 98004 | — |
| Retina Center NW, PLLC | Silverdale | Washington | 98383 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 109 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT04435366, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Oct 20, 2025 · Synced Sep 2, 2026
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Open the official record
The complete protocol, eligibility criteria, and contact information for NCT04435366 live on ClinicalTrials.gov.