EXPLORE: A Phase II Study to Evaluate the Safety and Efficacy of Two Doses of GT005
Public ClinicalTrials.gov record NCT04437368. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
EXPLORE: A Phase II, Outcomes Assessor-masked, Multicentre, Randomised Study to Evaluate the Safety and Efficacy of Two Doses of GT005 Administered as a Single Subretinal Injection in Subjects With Geographic Atrophy Secondary to Age-related Macular Degeneration
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
The purpose of this clinical study was to evaluate the safety and efficacy of two doses of GT005 administered as a single subretinal injection in subjects with geographic atrophy secondary to age-related macular degeneration (AMD).
Study identification
- NCT ID
- NCT04437368
- Recruitment status
- Terminated
- Study type
- Interventional
- Phase
- Phase 2
- Enrollment
- 98 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 55 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Apr 26, 2019 (Actual)
- Primary completion
- Apr 5, 2024 (Actual)
- Completion
- Apr 5, 2024 (Actual)
- Last update posted
- Jan 27, 2026
2019 – 2024
United States locations
- U.S. sites
- 32
- U.S. states
- 20
- U.S. cities
- 32
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Retinal Research Institute (retina consultants of AZ) | Phoenix | Arizona | 85053 | — |
| Retina Associates of Southern California | Huntington Beach | California | 92647 | — |
| Byers Eye Institute at Stanford | Palo Alto | California | 94303 | — |
| Retina Consultants San Diego | Poway | California | 92064 | — |
| VitreoRetinal Associates, P.A. | Gainesville | Florida | 32607 | — |
| Bascom Palmer Eye Institute | Miami | Florida | 33136 | — |
| Retina Vitreous Associates of Florida | St. Petersburg | Florida | 33711 | — |
| Southeast Retina Center | Augusta | Georgia | 30909 | — |
| University Retina Macula Associates PC | Lemont | Illinois | 60439 | — |
| Midwest Eye Institute Northside | Indianapolis | Indiana | 46290 | — |
| Wolfe Eye Clinic | West Des Moines | Iowa | 50266 | — |
| The Retina Care Center | Baltimore | Maryland | 21209 | — |
| Ophthalmic Consultants of Boston (OCB) | Boston | Massachusetts | 02114 | — |
| VitreoRetinal Surgery, PLLC | Minneapolis | Minnesota | 55435 | — |
| Sierra Eye Associates | Reno | Nevada | 89502 | — |
| Vision Research Center Eye Associates of New Mexico | Albuquerque | New Mexico | 87109 | — |
| Columbia University Medical Center | New York | New York | 10032 | — |
| Retina Associates of Western New York | Rochester | New York | 14620 | — |
| Cincinnati Eye Institute | Cincinnati | Ohio | 45242 | — |
| Cleveland Clinic | Cleveland | Ohio | 44195 | — |
| Oregon Retina | Eugene | Oregon | 97401 | — |
| Casey Eye Institute | Portland | Oregon | 97239 | — |
| Erie Retinal Surgery, INC | Erie | Pennsylvania | 16507 | — |
| Mid Atlantic Retina | Philadelphia | Pennsylvania | 19107 | — |
| Southeastern Retina Associates, PC | Knoxville | Tennessee | 37922 | — |
| Charles Retina Institute | Memphis | Tennessee | 38138 | — |
| Austin Research Center for Retina, PLLC | Austin | Texas | 78705 | — |
| Retina Consultants of Houston-TMC | Bellaire | Texas | 77401 | — |
| Texas Retina Associates | Dallas | Texas | 75231 | — |
| Retinal Consultants of San Antonio | San Antonio | Texas | 78240 | — |
| Department of Ophthalmology UW Medicine | Seattle | Washington | 98104-2499 | — |
| West Virginia University | Morgantown | West Virginia | 26506 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 23 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT04437368, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Jan 27, 2026 · Synced Oct 17, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT04437368 live on ClinicalTrials.gov.