ClinicalTrials.gov record
COVID-19 Study Assessing the Efficacy and Safety of Anti-Spike SARS CoV-2 Monoclonal Antibodies for Prevention of SARS CoV-2 Infection Asymptomatic in Healthy Adults and Adolescents Who Are Household Contacts to an Individual With a Positive SARS-CoV-2 RT-PCR Assay
ClinicalTrials.gov ID: NCT04452318
Public ClinicalTrials.gov record NCT04452318. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase 3, Randomized, Double-Blind, Placebo-Controlled Study Assessing the Efficacy and Safety of Anti-Spike SARS-CoV-2 Monoclonal Antibodies in Preventing SARS-CoV-2 Infection in Household Contacts of Individuals Infected With SARS-CoV-2
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
Primary Objectives: Cohort A: • To evaluate the efficacy of REGN10933+REGN10987 compared to placebo in preventing symptomatic SARS-CoV-2 infection (broad-term) confirmed by RT-qPCR Cohort A and Cohort A1: • To evaluate the safety and tolerability of REGN10933+REGN10987 following subcutaneous (SC) administration compared to placebo Cohort B • To evaluate the efficacy of REGN10933+REGN10987 compared to placebo in preventing COVID-19 symptoms (broad-term) Cohort B and Cohort B1 • To evaluate the safety and tolerability of REGN10933+REGN10987 following SC administration compared to placebo
Study identification
- NCT ID
- NCT04452318
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 3,303 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 1 Day and older
- Sex
- All
- Healthy volunteers
- Accepts healthy volunteers
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Jul 12, 2020
- Primary completion
- Oct 3, 2021
- Completion
- Oct 3, 2021
- Last update posted
- May 14, 2023
2020 – 2021
United States locations
- U.S. sites
- 132
- U.S. states
- 29
- U.S. cities
- 97
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Regeneron Study Site | Mesa | Arizona | 85210 | — |
| Regeneron Study Site | Tucson | Arizona | 85712 | — |
| Regeneron Study Site | Tucson | Arizona | 85724 | — |
| Regeneron Study Site | La Mesa | California | 91942 | — |
| Regeneron Study Site | La Palma | California | 90623 | — |
| Regeneron Study Site | Long Beach | California | 90806 | — |
| Regeneron Study Site | Los Angeles | California | 90035 | — |
| Regeneron Study Site | Los Angeles | California | 90036 | — |
| Regeneron Study Site | Los Angeles | California | 90095 | — |
| Regeneron Study Site | Montclair | California | 91763 | — |
| Regeneron Study Site | Northridge | California | 91324 | — |
| Regeneron Study Site | Oxnard | California | 93030 | — |
| Regeneron Study Site | Sacramento | California | 95817 | — |
| Regeneron Study Site | Sacramento | California | 95821 | — |
| Regeneron Study Site | San Diego | California | 92108 | — |
| Regeneron Study Site | San Francisco | California | 94127 | — |
| Regeneron Study Site | Stanford | California | 94305 | — |
| Regeneron Study Site | Torrance | California | 90502 | — |
| Regeneron Study Site | Torrance | California | 90505 | — |
| Regeneron Study Site | Aurora | Colorado | 80045 | — |
| Regeneron Study Site | Colorado Springs | Colorado | 80907 | — |
| Regeneron Study Site | Washington D.C. | District of Columbia | 20005 | — |
| Regeneron Study Site | Boca Raton | Florida | 33487 | — |
| Regeneron Study Site | Clearwater | Florida | 33756 | — |
| Regeneron Study Site | DeLand | Florida | 32720 | — |
| Regeneron Study Site | Ft. Pierce | Florida | 34982 | — |
| Regeneron Study Site | Hialeah | Florida | 33010 | — |
| Regeneron Study Site | Jacksonville | Florida | 32216 | — |
| Regeneron Study Site | Lakeland | Florida | 33810 | — |
| Regeneron Study Site | Loxahatchee Groves | Florida | 33470 | — |
| Regeneron Study Site | Maitland | Florida | 32751 | — |
| Regeneron Study Site | Miami | Florida | 33012 | — |
| Regeneron Study Site | Miami | Florida | 33125 | — |
| Regeneron Study Site | Miami | Florida | 33126 | — |
| Regeneron Study Site | Miami | Florida | 33136 | — |
| Regeneron Study Site | Miami | Florida | 33144 | — |
| Regeneron Study Site | Miami | Florida | 33184 | — |
| Regeneron Study Site | Miami | Florida | 33186 | — |
| Regeneron Study Site | Orlando | Florida | 32803 | — |
| Regeneron Study Site | Sarasota | Florida | 34239 | — |
| Regeneron Study Site | Tampa | Florida | 33612 | — |
| Regeneron Study Site | West Palm Beach | Florida | 33407 | — |
| Regeneron Study Site | Winter Park | Florida | 32789 | — |
| Regeneron Study Site | Atlanta | Georgia | 30303 | — |
| Regeneron Study Site | Atlanta | Georgia | 30322 | — |
| Regeneron Study Site | Columbus | Georgia | 31904 | — |
| Regeneron Study Site | Decatur | Georgia | 30030 | — |
| Regeneron Study Site | Eatonton | Georgia | 31024 | — |
| Regeneron Study Site | Marietta | Georgia | 30060 | — |
| Regeneron Study Site | Sandy Springs | Georgia | 30328 | — |
| Regeneron Study Site | Chicago | Illinois | 60607 | — |
| Regeneron Study Site 2 | Chicago | Illinois | 60612 | — |
| Regeneron Study Site 3 | Chicago | Illinois | 60612 | — |
| Regeneron Study Site | Chicago | Illinois | 60612 | — |
| Regeneron Study Site 1 | Downers Grove | Illinois | 60515 | — |
| Regeneron Study Site 2 | Downers Grove | Illinois | 60515 | — |
| Regeneron Study Site | Ames | Iowa | 50010-3014 | — |
| Regeneron Study Site | Lake Charles | Louisiana | 70601 | — |
| Regeneron Study Site | Marrero | Louisiana | 70072 | — |
| Regeneron Study Site | Metairie | Louisiana | 70006 | — |
| Regeneron Study Site | New Orleans | Louisiana | 70112 | — |
| Regeneron Study Site | Baltimore | Maryland | 21201 | — |
| Regeneron Study Site | Boston | Massachusetts | 02111 | — |
| Regeneron Study Site | Boston | Massachusetts | 02114 | — |
| Regeneron Study Site | Boston | Massachusetts | 02115 | — |
| Regeneron Study Site | Boston | Massachusetts | 02118 | — |
| Regeneron Study Site | Boston | Massachusetts | 02215 | — |
| Regeneron Study Site | Detroit | Michigan | 48202 | — |
| Regeneron Study Site | Royal Oak | Michigan | 48073 | — |
| Regeneron Study Site | Minneapolis | Minnesota | 55455 | — |
| Regeneron Study Site | Gulfport | Mississippi | 39503 | — |
| Regeneron Study Site | Jackson | Mississippi | 39216 | — |
| Regeneron Study Site | Hazelwood | Missouri | 63042 | — |
| Regeneron Study Site | St Louis | Missouri | 63110 | — |
| Regeneron Study Site | Las Vegas | Nevada | 89104 | — |
| Regeneron Study Site | Las Vegas | Nevada | 89109 | — |
| Regeneron Study Site | Morristown | New Jersey | 07960 | — |
| Regeneron Study Site | Newark | New Jersey | 07103 | — |
| Regeneron Study Site | Summit | New Jersey | 07901 | — |
| Regeneron Study Site | Teaneck | New Jersey | 07666-4245 | — |
| Regeneron Study Site | Buffalo | New York | 14203 | — |
| Regeneron Study Site | New York | New York | 10016 | — |
| Regeneron Study Site | New York | New York | 10027 | — |
| Regeneron Study Site | New York | New York | 10029 | — |
| Regeneron Study Site | New York | New York | 10032 | — |
| Regeneron Study Site | New York | New York | 10037 | — |
| Regeneron Study Site | New York | New York | 10065 | — |
| Regeneron Study Site 1 | The Bronx | New York | 10451 | — |
| Regeneron Study Site 2 | The Bronx | New York | 10451 | — |
| Regeneron Study Site | The Bronx | New York | 10461 | — |
| Regeneron Study Site | Chapel Hill | North Carolina | 27599 | — |
| Regeneron Study Site | Charlotte | North Carolina | 28209 | — |
| Regeneron Study Site | Fayetteville | North Carolina | 28304 | — |
| Regeneron Study Site | Raleigh | North Carolina | 27612 | — |
| Regeneron Study Site | Wilmington | North Carolina | 28401 | — |
| Regeneron Study Site | Winston-Salem | North Carolina | 27103 | — |
| Regeneron Study Site | Cincinnati | Ohio | 45267-0405 | — |
| Regeneron Study Site | Columbus | Ohio | 43210 | — |
| Regeneron Study Site | Columbus | Ohio | 43215 | — |
| Regeneron Study Site | Dayton | Ohio | 45432 | — |
| Regeneron Study Site | Danville | Pennsylvania | 17822 | — |
| Regeneron Study Site | Philadelphia | Pennsylvania | 19104 | — |
| Regeneron Study Site | Philadelphia | Pennsylvania | 19140 | — |
| Regeneron Study Site | Wilkes-Barre | Pennsylvania | 18711 | — |
| Regeneron Study Site | Providence | Rhode Island | 02906 | — |
| Regeneron Study Site | Charleston | South Carolina | 29406 | — |
| Regeneron Study Site | Charleston | South Carolina | 29425 | — |
| Regeneron Study Site | Clinton | South Carolina | 29325 | — |
| Regeneron Study Site | Gaffney | South Carolina | 29340 | — |
| Regeneron Study Site | Sioux Falls | South Dakota | 57105 | — |
| Regeneron Study Site | Chattanooga | Tennessee | 37421 | — |
| Regeneron Study Site | Knoxville | Tennessee | 37920 | — |
| Regeneron Study Site | Memphis | Tennessee | 38103 | — |
| Regeneron Study Site | Nashville | Tennessee | 37232 | — |
| Regeneron Study Site | Bellaire | Texas | 77401 | — |
| Regeneron Study Site | Corpus Christi | Texas | 78413 | — |
| Regeneron Study Site | Dallas | Texas | 75224 | — |
| Regeneron Study Site | Houston | Texas | 77008 | — |
| Regeneron Study Site | Houston | Texas | 77024 | — |
| Regeneron Study Site | Houston | Texas | 77026 | — |
| Regeneron Study Site | Houston | Texas | 77057 | — |
| Regeneron Study Site | Houston | Texas | 77093 | — |
| Regeneron Study Site | Pearland | Texas | 77584 | — |
| Regeneron Study Site | Red Oak | Texas | 75154 | — |
| Regeneron Study Site | San Antonio | Texas | 78249 | — |
| Regeneron Study Site | Tyler | Texas | 75701 | — |
| Regeneron Study Site | Charlottesville | Virginia | 22903 | — |
| Regeneron Study Site | Richmond | Virginia | 23298 | — |
| Regeneron Study Site | Everett | Washington | 98201 | — |
| Regeneron Study Site | Seattle | Washington | 98104 | — |
| Regeneron Study Site | Yakima | Washington | 98902 | — |
| Regeneron Study Site | Madison | Wisconsin | 53792 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 2 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT04452318, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted May 14, 2023 · Synced Sep 1, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete protocol, eligibility criteria, and contact information for NCT04452318 live on ClinicalTrials.gov.