ClinicalTrials.gov record
Terminated Phase 3 Interventional Results available

Testing the Addition of an Anti-cancer Immune Therapy Drug (Nivolumab) to the Usual Chemotherapy Treatment (Cisplatin or Carboplatin With Gemcitabine) for Recurrent or Metastatic Nasopharyngeal Cancer

ClinicalTrials.gov ID: NCT04458909

Public ClinicalTrials.gov record NCT04458909. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

ClinicalTrials.gov public records Last synced May 19, 2026, 11:21 AM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Official title

An Open-Label, Phase III Study of Platinum-Gemcitabine With or Without Nivolumab in the First-Line Treatment of Recurrent or Metastatic Nasopharyngeal Carcinoma

Study identification

NCT ID
NCT04458909
Recruitment status
Terminated
Study type
Interventional
Phase
Phase 3
Lead sponsor
National Cancer Institute (NCI)
NIH
Enrollment
15 participants

Conditions and interventions

Eligibility (public fields only)

Age range
18 Years and older
Sex
All
Healthy volunteers
Healthy volunteers not accepted

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date
Dec 8, 2020
Primary completion
Aug 14, 2023
Completion
Aug 14, 2023
Last update posted
Oct 2, 2025

2020 – 2023

United States locations

U.S. sites
322
U.S. states
33
U.S. cities
207
Facility City State ZIP Site status
University of Alabama at Birmingham Cancer Center Birmingham Alabama 35233
Anchorage Associates in Radiation Medicine Anchorage Alaska 98508
Anchorage Radiation Therapy Center Anchorage Alaska 99504
Alaska Breast Care and Surgery LLC Anchorage Alaska 99508
Alaska Oncology and Hematology LLC Anchorage Alaska 99508
Alaska Women's Cancer Care Anchorage Alaska 99508
Anchorage Oncology Centre Anchorage Alaska 99508
Katmai Oncology Group Anchorage Alaska 99508
Providence Alaska Medical Center Anchorage Alaska 99508
Cancer Center at Saint Joseph's Phoenix Arizona 85004
Mercy Hospital Fort Smith Fort Smith Arkansas 72903
CHI Saint Vincent Cancer Center Hot Springs Hot Springs Arkansas 71913
Mission Hope Medical Oncology - Arroyo Grande Arroyo Grande California 93420
Providence Saint Joseph Medical Center/Disney Family Cancer Center Burbank California 91505
Epic Care-Dublin Dublin California 94568
Bay Area Breast Surgeons Inc Emeryville California 94608
Epic Care Partners in Cancer Care Emeryville California 94608
Contra Costa Regional Medical Center Martinez California 94553-3156
Alta Bates Summit Medical Center - Summit Campus Oakland California 94609
Bay Area Tumor Institute Oakland California 94609
Stanford Cancer Institute Palo Alto Palo Alto California 94304
Pacific Central Coast Health Center-San Luis Obispo San Luis Obispo California 93401
Mission Hope Medical Oncology - Santa Maria Santa Maria California 93444
Epic Care Cyberknife Center Walnut Creek California 94597
Penrose-Saint Francis Healthcare Colorado Springs Colorado 80907
Rocky Mountain Cancer Centers-Penrose Colorado Springs Colorado 80907
Porter Adventist Hospital Denver Colorado 80210
Mercy Medical Center Durango Colorado 81301
Southwest Oncology PC Durango Colorado 81301
Saint Anthony Hospital Lakewood Colorado 80228
Littleton Adventist Hospital Littleton Colorado 80122
Longmont United Hospital Longmont Colorado 80501
Rocky Mountain Cancer Centers-Longmont Longmont Colorado 80501
Parker Adventist Hospital Parker Colorado 80138
Saint Mary Corwin Medical Center Pueblo Colorado 81004
Holy Cross Hospital Fort Lauderdale Florida 33308
Memorial Regional Hospital/Joe DiMaggio Children's Hospital Hollywood Florida 33021
Mayo Clinic in Florida Jacksonville Florida 32224-9980
Memorial Hospital West Pembroke Pines Florida 33028
Hawaii Cancer Care Inc - Waterfront Plaza Honolulu Hawaii 96813
Queen's Cancer Cenrer - POB I Honolulu Hawaii 96813
Queen's Medical Center Honolulu Hawaii 96813
Straub Clinic and Hospital Honolulu Hawaii 96813
University of Hawaii Cancer Center Honolulu Hawaii 96813
Kuakini Medical Center Honolulu Hawaii 96817
Queen's Cancer Center - Kuakini Honolulu Hawaii 96817
The Cancer Center of Hawaii-Liliha Honolulu Hawaii 96817
Kapiolani Medical Center for Women and Children Honolulu Hawaii 96826
Wilcox Memorial Hospital and Kauai Medical Clinic Lihue Hawaii 96766
Hawaii Cancer Care - Westridge ‘Aiea Hawaii 96701
Pali Momi Medical Center ‘Aiea Hawaii 96701
Queen's Cancer Center - Pearlridge ‘Aiea Hawaii 96701
The Cancer Center of Hawaii-Pali Momi ‘Aiea Hawaii 96701
Saint Alphonsus Cancer Care Center-Boise Boise Idaho 83706
Saint Luke's Cancer Institute - Boise Boise Idaho 83712
Saint Alphonsus Cancer Care Center-Caldwell Caldwell Idaho 83605
Kootenai Health - Coeur d'Alene Coeur d'Alene Idaho 83814
Walter Knox Memorial Hospital Emmett Idaho 83617
Saint Luke's Cancer Institute - Fruitland Fruitland Idaho 83619
Idaho Urologic Institute-Meridian Meridian Idaho 83642
Saint Luke's Cancer Institute - Meridian Meridian Idaho 83642
Saint Luke's Cancer Institute - Nampa Nampa Idaho 83686
Saint Alphonsus Cancer Care Center-Nampa Nampa Idaho 83687
Kootenai Clinic Cancer Services - Post Falls Post Falls Idaho 83854
Kootenai Cancer Clinic Sandpoint Idaho 83864
Saint Luke's Cancer Institute - Twin Falls Twin Falls Idaho 83301
Saint Anthony's Health Alton Illinois 62002
Rush - Copley Medical Center Aurora Illinois 60504
Illinois CancerCare-Bloomington Bloomington Illinois 61704
Illinois CancerCare-Canton Canton Illinois 61520
Memorial Hospital of Carbondale Carbondale Illinois 62902
SIH Cancer Institute Carterville Illinois 62918
Illinois CancerCare-Carthage Carthage Illinois 62321
Centralia Oncology Clinic Centralia Illinois 62801
Carle at The Riverfront Danville Illinois 61832
Cancer Care Specialists of Illinois - Decatur Decatur Illinois 62526
Decatur Memorial Hospital Decatur Illinois 62526
Illinois CancerCare-Dixon Dixon Illinois 61021
Carle Physician Group-Effingham Effingham Illinois 62401
Crossroads Cancer Center Effingham Illinois 62401
Illinois CancerCare-Eureka Eureka Illinois 61530
Illinois CancerCare-Galesburg Galesburg Illinois 61401
Western Illinois Cancer Treatment Center Galesburg Illinois 61401
Illinois CancerCare-Kewanee Clinic Kewanee Illinois 61443
Illinois CancerCare-Macomb Macomb Illinois 61455
Carle Physician Group-Mattoon/Charleston Mattoon Illinois 61938
Good Samaritan Regional Health Center Mount Vernon Illinois 62864
Cancer Care Center of O'Fallon O'Fallon Illinois 62269
Illinois CancerCare-Ottawa Clinic Ottawa Illinois 61350
Illinois CancerCare-Pekin Pekin Illinois 61554
Illinois CancerCare-Peoria Peoria Illinois 61615
Methodist Medical Center of Illinois Peoria Illinois 61636
Illinois CancerCare-Peru Peru Illinois 61354
Valley Radiation Oncology Peru Illinois 61354
Illinois CancerCare-Princeton Princeton Illinois 61356
Southern Illinois University School of Medicine Springfield Illinois 62702
Springfield Clinic Springfield Illinois 62702
Memorial Medical Center Springfield Illinois 62781
Carle Cancer Center Urbana Illinois 61801
The Carle Foundation Hospital Urbana Illinois 61801
Rush-Copley Healthcare Center Yorkville Illinois 60560
Reid Health Richmond Indiana 47374
Mary Greeley Medical Center Ames Iowa 50010
McFarland Clinic - Ames Ames Iowa 50010
McFarland Clinic - Boone Boone Iowa 50036
Saint Anthony Regional Hospital Carroll Iowa 51401
Medical Oncology and Hematology Associates-West Des Moines Clive Iowa 50325
Mercy Cancer Center-West Lakes Clive Iowa 50325
Alegent Health Mercy Hospital Council Bluffs Iowa 51503
Greater Regional Medical Center Creston Iowa 50801
Iowa Methodist Medical Center Des Moines Iowa 50309
Medical Oncology and Hematology Associates-Des Moines Des Moines Iowa 50309
Broadlawns Medical Center Des Moines Iowa 50314
Mercy Medical Center - Des Moines Des Moines Iowa 50314
Mission Cancer and Blood - Laurel Des Moines Iowa 50314
Iowa Lutheran Hospital Des Moines Iowa 50316
McFarland Clinic - Trinity Cancer Center Fort Dodge Iowa 50501
Trinity Regional Medical Center Fort Dodge Iowa 50501
McFarland Clinic - Jefferson Jefferson Iowa 50129
McFarland Clinic - Marshalltown Marshalltown Iowa 50158
Methodist West Hospital West Des Moines Iowa 50266-7700
Mercy Medical Center-West Lakes West Des Moines Iowa 50266
Central Care Cancer Center - Garden City Garden City Kansas 67846
Central Care Cancer Center - Great Bend Great Bend Kansas 67530
Flaget Memorial Hospital Bardstown Kentucky 40004
Commonwealth Cancer Center-Corbin Corbin Kentucky 40701
Saint Joseph Radiation Oncology Resource Center Lexington Kentucky 40504
Saint Joseph Hospital East Lexington Kentucky 40509
Saint Joseph London London Kentucky 40741
Jewish Hospital Louisville Kentucky 40202
Saints Mary and Elizabeth Hospital Louisville Kentucky 40215
UofL Health Medical Center Northeast Louisville Kentucky 40245
Jewish Hospital Medical Center South Shepherdsville Kentucky 40165
LSU Health Baton Rouge-North Clinic Baton Rouge Louisiana 70805
Louisiana Hematology Oncology Associates LLC Baton Rouge Louisiana 70809
Mary Bird Perkins Cancer Center Baton Rouge Louisiana 70809
Our Lady of the Lake Physicians Group - Medical Oncology Baton Rouge Louisiana 70809
Saint Joseph Mercy Hospital Ann Arbor Michigan 48106
Saint Joseph Mercy Brighton Brighton Michigan 48114
Trinity Health IHA Medical Group Hematology Oncology - Brighton Brighton Michigan 48114
Saint Joseph Mercy Canton Canton Michigan 48188
Trinity Health IHA Medical Group Hematology Oncology - Canton Canton Michigan 48188
Caro Cancer Center Caro Michigan 48723
Saint Joseph Mercy Chelsea Chelsea Michigan 48118
Trinity Health IHA Medical Group Hematology Oncology - Chelsea Hospital Chelsea Michigan 48118
Hematology Oncology Consultants-Clarkston Clarkston Michigan 48346
Newland Medical Associates-Clarkston Clarkston Michigan 48346
Ascension Saint John Hospital Detroit Michigan 48236
Great Lakes Cancer Management Specialists-Doctors Park East China Township Michigan 48054
Genesee Cancer and Blood Disease Treatment Center Flint Michigan 48503
Genesee Hematology Oncology PC Flint Michigan 48503
Genesys Hurley Cancer Institute Flint Michigan 48503
Hurley Medical Center Flint Michigan 48503
Academic Hematology Oncology Specialists Grosse Pointe Woods Michigan 48236
Great Lakes Cancer Management Specialists-Van Elslander Cancer Center Grosse Pointe Woods Michigan 48236
Michigan Breast Specialists-Grosse Pointe Woods Grosse Pointe Woods Michigan 48236
Sparrow Hospital Lansing Michigan 48912
Hope Cancer Clinic Livonia Michigan 48154
Trinity Health Saint Mary Mercy Livonia Hospital Livonia Michigan 48154
Great Lakes Cancer Management Specialists-Macomb Medical Campus Macomb Michigan 48044
Michigan Breast Specialists-Macomb Township Macomb Michigan 48044
Saint Mary's Oncology/Hematology Associates of Marlette Marlette Michigan 48453
21st Century Oncology-Pontiac Pontiac Michigan 48341
Hope Cancer Center Pontiac Michigan 48341
Newland Medical Associates-Pontiac Pontiac Michigan 48341
Saint Joseph Mercy Oakland Pontiac Michigan 48341
Great Lakes Cancer Management Specialists-Rochester Hills Rochester Hills Michigan 48309
Ascension Saint Mary's Hospital Saginaw Michigan 48601
Oncology Hematology Associates of Saginaw Valley PC Saginaw Michigan 48604
Bhadresh Nayak MD PC-Sterling Heights Sterling Heights Michigan 48312
Ascension Saint Joseph Hospital Tawas City Michigan 48764
Advanced Breast Care Center PLLC Warren Michigan 48088
Great Lakes Cancer Management Specialists-Macomb Professional Building Warren Michigan 48093
Macomb Hematology Oncology PC Warren Michigan 48093
Michigan Breast Specialists-Warren Warren Michigan 48093
Saint John Macomb-Oakland Hospital Warren Michigan 48093
Saint Mary's Oncology/Hematology Associates of West Branch West Branch Michigan 48661
Huron Gastroenterology PC Ypsilanti Michigan 48106
Trinity Health IHA Medical Group Hematology Oncology Ann Arbor Campus Ypsilanti Michigan 48197
Sanford Joe Lueken Cancer Center Bemidji Minnesota 56601
Mayo Clinic in Rochester Rochester Minnesota 55905
Sanford Thief River Falls Medical Center Thief River Falls Minnesota 56701
Sanford Cancer Center Worthington Worthington Minnesota 56187
Saint Louis Cancer and Breast Institute-Ballwin Ballwin Missouri 63011
Central Care Cancer Center - Bolivar Bolivar Missouri 65613
Saint Francis Medical Center Cape Girardeau Missouri 63703
Southeast Cancer Center Cape Girardeau Missouri 63703
Siteman Cancer Center at Saint Peters Hospital City of Saint Peters Missouri 63376
Siteman Cancer Center at West County Hospital Creve Coeur Missouri 63141
Parkland Health Center - Farmington Farmington Missouri 63640
Capital Region Southwest Campus Jefferson City Missouri 65109
Freeman Health System Joplin Missouri 64804
Mercy Hospital Joplin Joplin Missouri 64804
Delbert Day Cancer Institute at PCRMC Rolla Missouri 65401
Mercy Clinic-Rolla-Cancer and Hematology Rolla Missouri 65401
Heartland Regional Medical Center Saint Joseph Missouri 64506
Sainte Genevieve County Memorial Hospital Sainte Genevieve Missouri 63670
Mercy Hospital Springfield Springfield Missouri 65804
CoxHealth South Hospital Springfield Missouri 65807
Saint Louis Cancer and Breast Institute-South City St Louis Missouri 63109
Washington University School of Medicine St Louis Missouri 63110
Mercy Hospital South St Louis Missouri 63128
Siteman Cancer Center-South County St Louis Missouri 63129
Missouri Baptist Medical Center St Louis Missouri 63131
Siteman Cancer Center at Christian Hospital St Louis Missouri 63136
Mercy Hospital Saint Louis St Louis Missouri 63141
Missouri Baptist Sullivan Hospital Sullivan Missouri 63080
Missouri Baptist Outpatient Center-Sunset Hills Sunset Hills Missouri 63127
Mercy Hospital Washington Washington Missouri 63090
Community Hospital of Anaconda Anaconda Montana 59711
Billings Clinic Cancer Center Billings Montana 59101
Bozeman Deaconess Hospital Bozeman Montana 59715
Benefis Healthcare- Sletten Cancer Institute Great Falls Montana 59405
Great Falls Clinic Great Falls Montana 59405
Kalispell Regional Medical Center Kalispell Montana 59901
Saint Patrick Hospital - Community Hospital Missoula Montana 59802
Community Medical Hospital Missoula Montana 59804
CHI Health Saint Francis Grand Island Nebraska 68803
CHI Health Good Samaritan Kearney Nebraska 68847
Saint Elizabeth Regional Medical Center Lincoln Nebraska 68510
Nebraska Methodist Hospital Omaha Nebraska 68114
Alegent Health Immanuel Medical Center Omaha Nebraska 68122
Alegent Health Bergan Mercy Medical Center Omaha Nebraska 68124
Alegent Health Lakeside Hospital Omaha Nebraska 68130
Creighton University Medical Center Omaha Nebraska 68131
Midlands Community Hospital Papillion Nebraska 68046
Memorial Sloan Kettering Basking Ridge Basking Ridge New Jersey 07920
Memorial Sloan Kettering Monmouth Middletown New Jersey 07748
Memorial Sloan Kettering Bergen Montvale New Jersey 07645
Memorial Sloan Kettering Commack Commack New York 11725
Memorial Sloan Kettering Westchester Harrison New York 10604
Memorial Sloan Kettering Cancer Center New York New York 10065
Memorial Sloan Kettering Nassau Uniondale New York 11553
Sanford Bismarck Medical Center Bismarck North Dakota 58501
Sanford South University Medical Center Fargo North Dakota 58103
Southpointe-Sanford Medical Center Fargo Fargo North Dakota 58103
Sanford Medical Center Fargo Fargo North Dakota 58104
Sanford Broadway Medical Center Fargo North Dakota 58122
Sanford Roger Maris Cancer Center Fargo North Dakota 58122
Indu and Raj Soin Medical Center Beavercreek Ohio 45431
Saint Elizabeth Boardman Hospital Boardman Ohio 44512
Dayton Physicians LLC-Miami Valley South Centerville Ohio 45459
Miami Valley Hospital South Centerville Ohio 45459
University of Cincinnati Cancer Center-UC Medical Center Cincinnati Ohio 45219
Good Samaritan Hospital - Cincinnati Cincinnati Ohio 45220
Oncology Hematology Care Inc-Kenwood Cincinnati Ohio 45236
Bethesda North Hospital Cincinnati Ohio 45242
TriHealth Cancer Institute-Westside Cincinnati Ohio 45247
TriHealth Cancer Institute-Anderson Cincinnati Ohio 45255
Ohio State University Comprehensive Cancer Center Columbus Ohio 43210
Miami Valley Hospital Dayton Ohio 45409
Dayton Physician LLC-Miami Valley Hospital North Dayton Ohio 45415
Miami Valley Hospital North Dayton Ohio 45415
Armes Family Cancer Center Findlay Ohio 45840
Blanchard Valley Hospital Findlay Ohio 45840
Orion Cancer Care Findlay Ohio 45840
Atrium Medical Center-Middletown Regional Hospital Franklin Ohio 45005-1066
Dayton Physicians LLC-Atrium Franklin Ohio 45005
Dayton Physicians LLC-Wayne Greenville Ohio 45331
Wayne Hospital Greenville Ohio 45331
Greater Dayton Cancer Center Kettering Ohio 45409
Kettering Medical Center Kettering Ohio 45429
Springfield Regional Cancer Center Springfield Ohio 45504
Springfield Regional Medical Center Springfield Ohio 45505
Dayton Physicians LLC - Troy Troy Ohio 45373
Upper Valley Medical Center Troy Ohio 45373
Saint Joseph Warren Hospital Warren Ohio 44484
University of Cincinnati Cancer Center-West Chester West Chester Ohio 45069
Saint Elizabeth Youngstown Hospital Youngstown Ohio 44501
Cancer Centers of Southwest Oklahoma Research Lawton Oklahoma 73505
University of Oklahoma Health Sciences Center Oklahoma City Oklahoma 73104
Mercy Hospital Oklahoma City Oklahoma City Oklahoma 73120
Saint Alphonsus Medical Center-Baker City Baker City Oregon 97814
Saint Charles Health System Bend Oregon 97701
Clackamas Radiation Oncology Center Clackamas Oregon 97015
Providence Cancer Institute Clackamas Clinic Clackamas Oregon 97015
Bay Area Hospital Coos Bay Oregon 97420
Providence Newberg Medical Center Newberg Oregon 97132
Saint Alphonsus Medical Center-Ontario Ontario Oregon 97914
Providence Portland Medical Center Portland Oregon 97213
Providence Saint Vincent Medical Center Portland Oregon 97225
Saint Charles Health System-Redmond Redmond Oregon 97756
Lehigh Valley Hospital-Cedar Crest Allentown Pennsylvania 18103
Lehigh Valley Hospital - Muhlenberg Bethlehem Pennsylvania 18017
Pocono Medical Center East Stroudsburg Pennsylvania 18301
Lehigh Valley Hospital-Hazleton Hazleton Pennsylvania 18201
Sanford Cancer Center Oncology Clinic Sioux Falls South Dakota 57104
Sanford USD Medical Center - Sioux Falls Sioux Falls South Dakota 57117-5134
Saint Joseph Regional Cancer Center Bryan Texas 77802
VCU Massey Cancer Center at Stony Point Richmond Virginia 23235
Virginia Commonwealth University/Massey Cancer Center Richmond Virginia 23298
Providence Regional Cancer System-Aberdeen Aberdeen Washington 98520
PeaceHealth Saint Joseph Medical Center Bellingham Washington 98225
Harrison HealthPartners Hematology and Oncology-Bremerton Bremerton Washington 98310
Harrison Medical Center Bremerton Washington 98310
Highline Medical Center-Main Campus Burien Washington 98166
Providence Regional Cancer System-Centralia Centralia Washington 98531
Swedish Cancer Institute-Edmonds Edmonds Washington 98026
Saint Elizabeth Hospital Enumclaw Washington 98022
Providence Regional Cancer Partnership Everett Washington 98201
Saint Francis Hospital Federal Way Washington 98003
Swedish Cancer Institute-Issaquah Issaquah Washington 98029
Kadlec Clinic Hematology and Oncology Kennewick Washington 99336
Providence Regional Cancer System-Lacey Lacey Washington 98503
Saint Clare Hospital Lakewood Washington 98499
PeaceHealth Saint John Medical Center Longview Washington 98632
Harrison HealthPartners Hematology and Oncology-Poulsbo Poulsbo Washington 98370
Pacific Gynecology Specialists Seattle Washington 98104
Swedish Medical Center-Ballard Campus Seattle Washington 98107
Swedish Medical Center-Cherry Hill Seattle Washington 98122-5711
Swedish Medical Center-First Hill Seattle Washington 98122
PeaceHealth United General Medical Center Sedro-Woolley Washington 98284
Providence Regional Cancer System-Shelton Shelton Washington 98584
Franciscan Research Center-Northwest Medical Plaza Tacoma Washington 98405
Northwest Medical Specialties PLLC Tacoma Washington 98405
PeaceHealth Southwest Medical Center Vancouver Washington 98664
Providence Saint Mary Regional Cancer Center Walla Walla Washington 99362
Providence Regional Cancer System-Yelm Yelm Washington 98597
Saint Vincent Hospital Cancer Center Green Bay Green Bay Wisconsin 54301
Saint Vincent Hospital Cancer Center at Saint Mary's Green Bay Wisconsin 54303
Billings Clinic-Cody Cody Wyoming 82414
Welch Cancer Center Sheridan Wyoming 82801

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

Non-U.S. locations

This page focuses on the U.S. directory. The official record also lists 3 non-U.S. sites.

About this trial record page

What this page shows
Public field values for ClinicalTrials.gov record NCT04458909, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do
No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from
Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh
Last update posted Oct 2, 2025 · Synced May 19, 2026

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Open the official record

The complete protocol, eligibility criteria, and contact information for NCT04458909 live on ClinicalTrials.gov.

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