Optimizing Retention, Duration and Discontinuation Strategies for Opioid Use Disorder Pharmacotherapy (RDD)
Public ClinicalTrials.gov record NCT04464980. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
NIDA-CTN-0100: Optimizing Retention, Duration and Discontinuation Strategies for Opioid Use Disorder Pharmacotherapy (RDD)
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
This is a two phase study investigating combinations of pharmacological and behavioral interventions to optimize the treatment of Opioid Use Disorder (OUD). The Retention Phase will assess strategies for improving retention on buprenorphine (BUP) and extended-release injectable naltrexone (XR-NTX). The Discontinuation Phase will assess which approaches are most likely to lead to long-term success (absence of relapse), and what characteristics of participants distinguish those who can safely discontinue Medications for Opioid Use Disorder (MOUD) from those who remain at risk of relapse and should not discontinue.
Study identification
- NCT ID
- NCT04464980
- Recruitment status
- Active, not recruiting
- Study type
- Interventional
- Phase
- Phase 2
- Enrollment
- 1,516 participants
Conditions and interventions
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Jun 7, 2021
- Primary completion
- Dec 30, 2026
- Completion
- Jan 30, 2027
- Last update posted
- Aug 31, 2026
2021 – 2027
United States locations
- U.S. sites
- 21
- U.S. states
- 15
- U.S. cities
- 20
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| University of Arkansas for Medical Sciences (UAMS) / Center for Addiction Services and Treatment (CAST) | Little Rock | Arkansas | 72205 | — |
| Tarzana Treatment Centers, Inc. | Tarzana | California | 91356 | — |
| Liberation Programs, Inc. | Bridgeport | Connecticut | 06610 | — |
| Operation PAR | Clearwater | Florida | 33760 | — |
| Gateway Community Services | Jacksonville | Florida | 32204 | — |
| Aspire Health Partners | Orlando | Florida | 32806 | — |
| Mountain Manor / Maryland Treatment Centers | Baltimore | Maryland | 21229 | — |
| McLean Hospital | Belmont | Massachusetts | 02478 | — |
| Stanley Street Treatment and Resources, Inc. | Fall River | Massachusetts | 02720 | — |
| Square Medical Group, LLC | Newton | Massachusetts | 02458 | — |
| Gibson Center for Behavioral Change | Cape Girardeau | Missouri | 63703 | — |
| Dartmouth Hitchcock - ATP | Lebanon | New Hampshire | 03766 | — |
| University of New Mexico Addiction and Substance Abuse Program | Albuquerque | New Mexico | 87106 | — |
| Bellevue Hospital Center | New York | New York | 10016 | — |
| Adapt Integrated Health Care | Roseburg | Oregon | 97470 | — |
| Adapt Integrated Health Care | Winston | Oregon | 97496 | — |
| Center for Psychiatric and Chemical Dependency Services (CPCDS) | Pittsburgh | Pennsylvania | 15213 | — |
| Internal Medicine Recovery Engagement Program (IM-REP) | Pittsburgh | Pennsylvania | 15219 | — |
| Shoreline Behavioral Health Services | Conway | South Carolina | 29526 | — |
| Huntsman Mental Health Institute / University of Utah | Salt Lake City | Utah | 84108 | — |
| Chestnut Ridge Center | Morgantown | West Virginia | 26505 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT04464980, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Aug 31, 2026 · Synced Sep 5, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete protocol, eligibility criteria, and contact information for NCT04464980 live on ClinicalTrials.gov.