Study of Oral Navitoclax Tablet in Combination With Oral Ruxolitinib Tablet Versus Best Available Therapy to Assess Change in Spleen Volume in Adult Participants With Relapsed/Refractory Myelofibrosis
Public ClinicalTrials.gov record NCT04468984. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
Randomized, Open-Label, Phase 3 Study Evaluating Efficacy and Safety of Navitoclax in Combination With Ruxolitinib Versus Best Available Therapy in Subjects With Relapsed/Refractory Myelofibrosis (TRANSFORM-2), Incorporating Extension Arm C - Continued Access for Navitoclax to Roll Over Subjects From Studies M10-166, M16-109, M16-191, and M19-753
Study identification
- NCT ID
- NCT04468984
- Recruitment status
- Active, not recruiting
- Study type
- Interventional
- Phase
- Phase 3
- Lead sponsor
- AbbVie
- Industry
- Enrollment
- 330 participants
Conditions and interventions
Conditions
Interventions
- Navitoclax Drug
- Ruxolitinib Drug
- Best Available Therapy (BAT) Drug
Drug
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Aug 30, 2020
- Primary completion
- Jan 28, 2025
- Completion
- Nov 30, 2026
- Last update posted
- Jan 8, 2026
2020 – 2026
United States locations
- U.S. sites
- 41
- U.S. states
- 22
- U.S. cities
- 37
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Ironwood Cancer & Res Ctr /ID# 222162 | Chandler | Arizona | 85224-5665 | — |
| Highlands Oncology Group, PA /ID# 221826 | Springdale | Arkansas | 72762 | — |
| City of Hope /ID# 218996 | Duarte | California | 91010 | — |
| Providence - St. Jude Medical Center /ID# 271382 | Fullerton | California | 92835 | — |
| Moores Cancer Center /ID# 271596 | La Jolla | California | 92037 | — |
| Moores Cancer Center at UC San Diego /ID# 219009 | La Jolla | California | 92093 | — |
| Long Beach Memorial Medical Ct /ID# 224542 | Long Beach | California | 90806-1701 | — |
| Icri /Id# 221967 | Whittier | California | 90603 | — |
| St. Mary's Hospital Regional Cancer Center /ID# 224229 | Grand Junction | Colorado | 81501-6132 | — |
| Augusta University Georgia Cancer Center /ID# 219051 | Augusta | Georgia | 30912-0003 | — |
| Columbus Regional Research Institute /ID# 224410 | Columbus | Georgia | 31904-8915 | — |
| University of Chicago Medical Center /ID# 271373 | Chicago | Illinois | 60637 | — |
| Northwest Oncology & Hematology - Elk Grove Village /ID# 222818 | Elk Grove Village | Illinois | 60007-3361 | — |
| Loyola University Medical Ctr /ID# 219048 | Maywood | Illinois | 60153 | — |
| Indiana Blood & Marrow Transpl /ID# 221587 | Indianapolis | Indiana | 46237 | — |
| Tulane Medical Center - New Orleans /ID# 222940 | New Orleans | Louisiana | 70112-2600 | — |
| Duplicate_Ochsner Clinic Foundation-New Orleans /ID# 222777 | New Orleans | Louisiana | 70121 | — |
| American Oncology Partners of Maryland /ID# 222836 | Bethesda | Maryland | 20817 | — |
| Dana-Farber Cancer Institute /ID# 218998 | Boston | Massachusetts | 02215 | — |
| University of Michigan /ID# 218463 | Ann Arbor | Michigan | 48109 | — |
| Henry Ford Hospital /ID# 221190 | Detroit | Michigan | 48202 | — |
| William Beaumont Hospital /ID# 222705 | Royal Oak | Michigan | 48073-6710 | — |
| Saint Louis University Cancer Center /ID# 222287 | St Louis | Missouri | 63110-2539 | — |
| Summit Medical Group-Florham Park /ID# 222620 | Florham Park | New Jersey | 07932-1049 | — |
| Hackensack Univ Med Ctr /ID# 219047 | Hackensack | New Jersey | 07601 | — |
| The Cancer Institute at St. Francis Hospital /ID# 231782 | Greenvale | New York | 11548-1219 | — |
| Manhattan Hematology Oncology MHO Associates /ID# 223193 | New York | New York | 10016-6028 | — |
| Memorial Sloan Kettering Cancer Center-Koch Center /ID# 221081 | New York | New York | 10065-6007 | — |
| Atrium Health Wake Forest Baptist Medical Center /ID# 222899 | Winston-Salem | North Carolina | 27157-0001 | — |
| MetroHealth Medical Center /ID# 222650 | Cleveland | Ohio | 44109 | — |
| Pennsylvania Cancer Specialists & Research Institute /ID# 271376 | Gettysburg | Pennsylvania | 17325 | — |
| Hospital of the University of Pennsylvania /ID# 219001 | Philadelphia | Pennsylvania | 19104-4238 | — |
| Fox Chase Cancer Center /ID# 223955 | Philadelphia | Pennsylvania | 19111 | — |
| Texas Oncology - Abilene - Antilley Road /ID# 271379 | Abilene | Texas | 79606 | — |
| Duplicate_Houston Methodist Hospital /ID# 223103 | Houston | Texas | 77030 | — |
| University of Texas Health San Antonio MD Anderson Cancer Center /ID# 233942 | San Antonio | Texas | 78229 | — |
| Utah Cancer Specialists Salt Lake Clinic /ID# 221962 | Salt Lake City | Utah | 84106 | — |
| Virginia Cancer Specialists - Fairfax /ID# 223016 | Fairfax | Virginia | 22031 | — |
| Providence Everett /ID# 223130 | Everett | Washington | 98201 | — |
| Yakima Valley Memorial Hosp /ID# 224368 | Yakima | Washington | 98902-6388 | — |
| HSHS St. Vincent Hospital /ID# 224468 | Green Bay | Wisconsin | 54301 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 188 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT04468984, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Jan 8, 2026 · Synced Jul 22, 2026
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Open the official record
The complete protocol, eligibility criteria, and contact information for NCT04468984 live on ClinicalTrials.gov.