The Synergy Disc To Anterior Cervical Discectomy and Fusion
Public ClinicalTrials.gov record NCT04469231. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Multi-Center, Prospective, Historically Controlled Pivotal Trial Comparing The Safety And Effectiveness Of The Synergy Disc To Anterior Cervical Discectomy And Fusion In Patients With One-Level Symptomatic Cervical Degenerative Disc Disease (DDD).
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
A multicenter, prospective, non-randomized, historically controlled study. Demonstrate the Synergy Disc is at least as safe and effective as conventional anterior cervical discectomy and fusion (ACDF) to treat cervical degenerative disc disease (DDD) in subjects who are symptomatic at only one level from C3 to C7 that are unresponsive to conservative management. Patients will be evaluated preoperatively, at the time of surgery, and at 6 weeks, 3, 6, 12, and 24 months after surgery. Follow-up will continue annually until the last patient reaches 24-month follow-up. The primary analysis will occur at 24 months.
Study identification
- NCT ID
- NCT04469231
- Recruitment status
- Active, not recruiting
- Study type
- Interventional
- Phase
- Not applicable
- Enrollment
- 175 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years to 70 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Oct 30, 2020 (Actual)
- Primary completion
- Jun 19, 2025 (Actual)
- Completion
- Jan 1, 2026 (Estimated)
- Last update posted
- Nov 19, 2025
2020 – 2026
United States locations
- U.S. sites
- 20
- U.S. states
- 13
- U.S. cities
- 18
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Barrow Brain and Spine | Phoenix | Arizona | 85013 | — |
| HonorHealth Research Institute/Barrow Brain and Spine | Scottsdale | Arizona | 85251 | — |
| Todd H. Lanman, M.D. | Beverly Hills | California | 90210 | — |
| Orthopedic Specialty Institute | Orange | California | 92868 | — |
| Institute of Neuro Innovation | Santa Monica | California | 90404 | — |
| Anschutz Medical Center | Aurora | Colorado | 80045 | — |
| Kennedy White Orthopaedic Center | Sarasota | Florida | 34232 | — |
| Indiana Spine Group | Carmel | Indiana | 46032 | — |
| Michigan Orthopedic Surgeons (2) | Southfield | Michigan | 48033 | — |
| Michigan Orthopedic Surgeons | Southfield | Michigan | 48033 | — |
| Upstate Medical University | East Syracuse | New York | 13057 | — |
| Hospital for Special Surgery | New York | New York | 10021 | — |
| Exiamia EquiHealth | Durham | North Carolina | 27704 | — |
| Summit Spine | Portland | Oregon | 97225 | — |
| Center for Sports Medicine and Orthopaedic Surgery (CSMO) | Chattanooga | Tennessee | 37404 | — |
| Central Texas Brain & Spine | Austin | Texas | 78705 | — |
| Austin Neurosurgeons | Austin | Texas | 78746 | — |
| Texas Spine Care Center | San Antonio | Texas | 78231 | — |
| The Disc Replacement Center | West Jordan | Utah | 84088 | — |
| Atlantic Brain & Spine | Reston | Virginia | 20190 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT04469231, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Nov 19, 2025 · Synced Oct 21, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT04469231 live on ClinicalTrials.gov.