ClinicalTrials.gov record
Pivotal, Randomized, Open-label Study of Optune® (Tumor Treating Fields) Concomitant With RT & TMZ for the Treatment of Newly Diagnosed GBM
ClinicalTrials.gov ID: NCT04471844
Public ClinicalTrials.gov record NCT04471844. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
EF-32: Pivotal, Randomized, Open-Label Study of Optune® (Tumor Treating Fields, 200kHz) Concomitant With Radiation Therapy and Temozolomide for the Treatment of Newly Diagnosed Glioblastoma
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
To test the effectiveness and safety of Optune® given concomitantly with radiation therapy (RT) and temozolomide (TMZ) in newly diagnosed GBM patients, compared to radiation therapy and temozolomide alone. In both arms, Optune® and maintenance temozolomide are continued following radiation therapy.
Study identification
- NCT ID
- NCT04471844
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Not applicable
- Enrollment
- 981 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Dec 7, 2020
- Primary completion
- Feb 18, 2026
- Completion
- Feb 18, 2026
- Last update posted
- Mar 29, 2026
2020 – 2026
United States locations
- U.S. sites
- 87
- U.S. states
- 35
- U.S. cities
- 71
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Grandview Cancer Center | Birmingham | Alabama | 35243 | — |
| Banner MD Anderson Cancer Center | Gilbert | Arizona | 85234 | — |
| Mayo Clinic- Arizona | Phoenix | Arizona | 85054 | — |
| University of Arizona Cancer Center | Tucson | Arizona | 85719 | — |
| Highlands Oncology Group | Fayetteville | Arkansas | 72762 | — |
| Providence St. Joseph Medical Center and The Roy and Patricia Disney Family Cancer Center | Burbank | California | 91505 | — |
| City of Hope National Medical Center | Duarte | California | 91010 | — |
| TRIO - St. Jude Heritage Healthcare/St. Jude Medical Center | Fullerton | California | 92835 | — |
| University of California at San Diego - Moores Cancer Center | La Jolla | California | 92093 | — |
| Norris Comprehensive Cancer Center at USC | Los Angeles | California | 90033 | — |
| Cedars - Sinai Medical Center | Los Angeles | California | 90048 | — |
| Hoag Memorial Hospital - Hoag Cancer Center | Newport Beach | California | 92663 | — |
| St. Joseph Hospital of Orange | Orange | California | 92868 | — |
| University of California - Irvine/UCI Medical Center | Orange | California | 92868 | — |
| Stanford University Cancer Institute | Palo Alto | California | 94303 | — |
| Sharp Memorial Hospital - X-Ray Medical Group Radiation Oncology | San Diego | California | 92123 | — |
| University of California San Francisco Medical Center | San Francisco | California | 94143 | — |
| John Wayne Cancer Institute at St. John's Health Center | Santa Monica | California | 90404 | — |
| University of Colorado Cancer Center Anschutz | Aurora | Colorado | 80045 | — |
| HCA Research Institute - Blue Sky Neurology - Denver | Englewood | Colorado | 80113 | — |
| Hartford Healthcare Medical Group - Hartford Hospital The Gray Cancer Center | Hartford | Connecticut | 06106 | — |
| Lynn Cancer Institute, Marcus Neuroscience Institute | Boca Raton | Florida | 33486 | — |
| Baptist Health - Jacksonville | Jacksonville | Florida | 32207 | — |
| Mayo Clinic | Jacksonville | Florida | 32224 | — |
| AdventHealth | Orlando | Florida | 32804 | — |
| Orlando Health UF Health Cancer Center | Orlando | Florida | 32806 | — |
| H. Lee Moffitt Cancer Center and Research Institute, Inc | Tampa | Florida | 33612 | — |
| Piedmont Healthcare Brain Tumor Center | Atlanta | Georgia | 30309 | — |
| The Emory Clinic - Emory Healthcare - Winship Cancer Institute | Atlanta | Georgia | 30322 | — |
| Northside Hospital, Inc. | Atlanta | Georgia | 30342 | — |
| Rush University Medical Center | Chicago | Illinois | 60612 | — |
| University of Chicago | Chicago | Illinois | 60617 | — |
| Parkview Cancer Institute - Fort Wayne Radiation Oncology Associates | Fort Wayne | Indiana | 46845 | — |
| The University of Kansas Cancer Center | Topeka | Kansas | 66606 | — |
| University of Louisville - James Graham Brown Cancer Center | Louisville | Kentucky | 40202 | — |
| Norton Cancer Institute | Louisville | Kentucky | 40241 | — |
| Mary Bird Cancer Center Neuromedical Center | Baton Rouge | Louisiana | 70810 | — |
| LSU Health Sciences Center, New Orleans | New Orleans | Louisiana | 70072 | — |
| Ochsner Health System | New Orleans | Louisiana | 70121-2429 | — |
| Maine Medical Partners Neurology - Neurosurgery & Spine Associates | South Portland | Maine | 04106 | — |
| John Hopkins School of Medicine | Baltimore | Maryland | 21287 | — |
| Tufts Medical Center | Boston | Massachusetts | 02111 | — |
| University of Massachusetts Chan Medical School | Worcester | Massachusetts | 01655 | — |
| University of Michigan Comprehensive Cancer Center | Ann Arbor | Michigan | 48109 | — |
| Abbott Northwestern Hospital - Givens Brain Tumor Center | Minneapolis | Minnesota | 55407 | — |
| University of Mississippi Medical Center | Jackson | Mississippi | 39216 | — |
| University of Missouri - Ellis Fischel Cancer Center | Columbia | Missouri | 65212 | — |
| Health Midwest Ventures Group, Inc - Sarah Cannon HCA Midwest Brain and Spine | Kansas City | Missouri | 64132 | — |
| Washington University School of Medicine | St Louis | Missouri | 63110 | — |
| Dartmouth-Hitchcock Medical Center | Lebanon | New Hampshire | 03756 | — |
| JFK Neuroscience Institute, HMH JFK University Medical Center | Edison | New Jersey | 08820 | — |
| Hackensack University Medical Center - John Theurer Cancer Center | Hackensack | New Jersey | 07601 | — |
| Jersey Shore University Medical Center | Neptune City | New Jersey | 07753 | — |
| Northwell Health System Brain Tumor Center | Lake Success | New York | 11042 | — |
| NYU Langone - Laura & Issac Perimutter Cancer Center | New York | New York | 10016 | — |
| Mount Sinai - Icahn School of Medicine | New York | New York | 10029 | — |
| New York Presbyterian - Columbia University | New York | New York | 10032 | — |
| University of Rochester Medical Center | Rochester | New York | 14642 | — |
| SUNY Upstate Medical University | Syracuse | New York | 13210 | — |
| University of North Carolina Brain Tumor Program - UNC Lineberger Comprehensive Cancer Center | Chapel Hill | North Carolina | 27599 | — |
| Novant Health Cancer Institute Radiation Oncology | Charlotte | North Carolina | 28204 | — |
| Vidant Medical Center | Greenville | North Carolina | 27834 | — |
| Forsyth Medical Center-Novant Health | Winston-Salem | North Carolina | 27103 | — |
| Wake Forest Baptist Comprehensive Cancer Center | Winston-Salem | North Carolina | 27157 | — |
| University of Cincinnati Cancer Institute | Cincinnati | Ohio | 45219 | — |
| The James Cancer Hospital and Solove Research Institute - Arthur G James Cancer Hospital | Columbus | Ohio | 43210 | — |
| Oregon Health & Science University (OHSU) | Portland | Oregon | 97239 | — |
| Neuroscience Center, Philadelphia - University of Pennsylvania | Philadelphia | Pennsylvania | 19104 | — |
| Thomas Jefferson University Hospital | Philadelphia | Pennsylvania | 19107 | — |
| Allegheny Health Network Cancer Institute | Pittsburgh | Pennsylvania | 15212 | — |
| UPMC Hillman Cancer Center | Pittsburgh | Pennsylvania | 15232 | — |
| Rhode Island Hospital | Providence | Rhode Island | 02903 | — |
| MUSC Radiation Oncology Brain & Spine Tumor Program | Charleston | South Carolina | 29425 | — |
| SCRI - Tennessee Oncology | Chattanooga | Tennessee | 37404 | — |
| West Cancer Center - Germantown | Germantown | Tennessee | 38138 | — |
| SCRI - Tennessee Oncology | Nashville | Tennessee | 37203 | — |
| Texas Oncology Midtown - Austin Brain Tumor Center | Austin | Texas | 78705 | — |
| Baylor Charles A. Sammons Cancer Center - Baylor University Medical Center | Dallas | Texas | 75246 | — |
| John Peter Smith Health Network - JPS Cancer Center | Fort Worth | Texas | 76104 | — |
| Houston Methodist Hospital | Houston | Texas | 77030 | — |
| UT Health Mischer Neuroscience - Memorial Herman - UT Neurosciences | Houston | Texas | 77030 | — |
| Baylor Scott & White Medical Center | Temple | Texas | 76508 | — |
| The University of Vermont Medical Center - University of Vermont Cancer Center | Burlington | Vermont | 05401 | — |
| Massey Cancer Center - VCU Medical Center | Richmond | Virginia | 23298 | — |
| UW Medical Center - Alvord Brain Tumor Center | Seattle | Washington | 98109 | — |
| Swedish Health Services | Seattle | Washington | 98122 | — |
| West Virginia University Cancer Institute | Morgantown | West Virginia | 26506 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 46 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT04471844, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Mar 29, 2026 · Synced Sep 2, 2026
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Open the official record
The complete protocol, eligibility criteria, and contact information for NCT04471844 live on ClinicalTrials.gov.