Evaluation of the Efficacy and Safety of VX-864 in Subjects With the PiZZ Genotype
Public ClinicalTrials.gov record NCT04474197. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase 2, Randomized, Double-blind, Placebo-controlled Study of the Efficacy and Safety of VX-864 in PiZZ Subjects
Study identification
- NCT ID
- NCT04474197
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 2
- Lead sponsor
- Vertex Pharmaceuticals Incorporated
- Industry
- Enrollment
- 44 participants
Conditions and interventions
Conditions
Interventions
- VX-864 Drug
- Placebo Drug
Drug
Eligibility (public fields only)
- Age range
- 18 Years to 80 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Jul 23, 2020
- Primary completion
- May 3, 2021
- Completion
- May 3, 2021
- Last update posted
- May 25, 2022
2020 – 2021
United States locations
- U.S. sites
- 22
- U.S. states
- 16
- U.S. cities
- 22
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| University of Alabama at Birmingham | Birmingham | Alabama | 35233 | — |
| David Geffen School of Medicine at UCLA | Los Angeles | California | 90095 | — |
| University of California Davis Medical Center | Sacramento | California | 95817 | — |
| National Jewish Health | Denver | Colorado | 80206 | — |
| University of Florida | Gainesville | Florida | 11735 | — |
| University of Miami Miller School of Medicine | Miami | Florida | 33136 | — |
| Central Florida Pulmonary | Orlando | Florida | 32803 | — |
| The University of Iowa Hospitals and Clinics | Iowa City | Iowa | 52242 | — |
| University of Kansas Medical Center | Kansas City | Kansas | 66160 | — |
| University of Minnesota | Minneapolis | Minnesota | 55455 | — |
| Blessing Corporate Services, Inc., dba Blessing Health System | Hannibal | Missouri | 63401 | — |
| Cardinal Glennon Children's Hospital - St. Louis University | St Louis | Missouri | 63104 | — |
| University of North Carolina Medical Center | Chapel Hill | North Carolina | 27514 | — |
| Wake Forest University Baptist Medical Center | Winston-Salem | North Carolina | 27157 | — |
| University of Cincinnati | Cincinnati | Ohio | 45229 | — |
| Oregon Health & Science University | Portland | Oregon | 97239 | — |
| Temple University Hospital | Philadelphia | Pennsylvania | 19140 | — |
| Medical University of South Carolina | Charleston | South Carolina | 29425 | — |
| Renovatio Clinical | Houston | Texas | 77380 | — |
| The University of Texas Health Science Center at Tyler | Tyler | Texas | 75708 | — |
| University of Utah Health | Salt Lake City | Utah | 84108 | — |
| Inova Fairfax Medical Campus | Falls Church | Virginia | 22042 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 8 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT04474197, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted May 25, 2022 · Synced Jul 22, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete protocol, eligibility criteria, and contact information for NCT04474197 live on ClinicalTrials.gov.