A Comparative Study of Sage-217 Plus an Antidepressant (ADT) Versus Placebo Plus an ADT in Adults With Major Depressive Disorder
Public ClinicalTrials.gov record NCT04476030. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase 3, Randomized, Double-Blind Study Comparing the Efficacy and Safety of SAGE-217 Plus an Antidepressant Versus Placebo Plus an Antidepressant in Adults With Major Depressive Disorder
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
The primary purpose of this study is to evaluate the efficacy of SAGE-217 plus an ADT in the treatment of major depressive disorder (MDD) compared to placebo plus an ADT.
Study identification
- NCT ID
- NCT04476030
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 440 participants
Conditions and interventions
Conditions
Interventions
- SAGE-217 Drug
- Matching Placebo Drug
- Sertraline Drug
- Escitalopram Drug
- Citalopram Drug
- Duloxetine Drug
- Desvenlafaxine Drug
Drug
Eligibility (public fields only)
- Age range
- 18 Years to 64 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Nov 9, 2020 (Actual)
- Primary completion
- Oct 25, 2021 (Actual)
- Completion
- Dec 22, 2021 (Actual)
- Last update posted
- Dec 22, 2023
2020 – 2021
United States locations
- U.S. sites
- 51
- U.S. states
- 21
- U.S. cities
- 45
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Sage Investigational Site | Dothan | Alabama | 36303 | — |
| Sage Investigational Site | Phoenix | Arizona | 85012 | — |
| Sage Investigational Site | Anaheim | California | 92805 | — |
| Sage Investigational Site | Costa Mesa | California | 92626 | — |
| Sage Investigational Site | Glendale | California | 91206 | — |
| Sage Investigational Site | Irvine | California | 92614 | — |
| Sage Investigational Site | Los Alamitos | California | 90720 | — |
| Sage Investigational Site | Oceanside | California | 92056 | — |
| Sage Investigational Site | Orange | California | 92868 | — |
| Sage Investigational Site | Riverside | California | 92503 | — |
| Sage Investigational Site | San Diego | California | 92103 | — |
| Sage Investigational Site | Temecula | California | 92591 | — |
| Sage Investigational Site | Colorado Springs | Colorado | 80910 | — |
| Sage Investigational Site | Cromwell | Connecticut | 06416 | — |
| Sage Investigational Site | Norwich | Connecticut | 06360 | — |
| Sage Investigational Site | Coral Springs | Florida | 33067 | — |
| Sage Investigational Site | Jacksonville | Florida | 32256 | — |
| Sage Investigational Site | Orlando | Florida | 32801 | — |
| Sage Investigational Site | Orlando | Florida | 32807 | — |
| Sage Investigational Site | Pensacola | Florida | 32502 | — |
| Sage Investigational Site | Alpharetta | Georgia | 30022 | — |
| Sage Investigational Site | Atlanta | Georgia | 30331 | — |
| Sage Investigational Site | Marietta | Georgia | 30060 | — |
| Sage Investigational Site | Savannah | Georgia | 31405 | — |
| Sage Investigational Site | Chicago | Illinois | 60634 | — |
| Sage Investigational Site | Chicago | Illinois | 60640 | — |
| Sage Investigational Site | Towson | Maryland | 21204 | — |
| Sage Investigational Site | Watertown | Massachusetts | 02472 | — |
| Sage Investigational Site | Ann Arbor | Michigan | 48109 | — |
| Sage Investigational Site | Saint Charles | Missouri | 63304 | — |
| Sage Investigational Site | Lincoln | Nebraska | 68526 | — |
| Sage Investigational Site | Cherry Hill | New Jersey | 08002 | — |
| Sage Investigational Site | Marlton | New Jersey | 08053 | — |
| Sage Investigational Site | Princeton | New Jersey | 08540 | — |
| Sage Investigational Site | Albuquerque | New Mexico | 87109 | — |
| Sage Investigational Site | Brooklyn | New York | 11229 | — |
| Sage Investigational Site | Brooklyn | New York | 11235 | — |
| Sage Investigational Site | Mount Kisco | New York | 10549 | — |
| Sage Investigational Site | Beachwood | Ohio | 44122 | — |
| Sage Investigational Site | Cincinnati | Ohio | 45212 | — |
| Sage Investigational Site | Cincinnati | Ohio | 45215 | — |
| Sage Investigational Site | Cincinnati | Ohio | 45219 | — |
| Sage Investigational Site | North Canton | Ohio | 44720 | — |
| Sage Investigational Site | Oklahoma City | Oklahoma | 73112 | — |
| Sage Investigational Site | Plymouth Meeting | Pennsylvania | 19462 | — |
| Sage Investigational Site | Austin | Texas | 78759 | — |
| Sage Investigational Site | Dallas | Texas | 75231 | — |
| Sage Investigational Site | Houston | Texas | 77030 | — |
| Sage Investigational Site | Houston | Texas | 77081 | — |
| Sage Investigational Site | Wichita Falls | Texas | 76309 | — |
| Sage Investigational Site | Bellevue | Washington | 98007 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT04476030, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Dec 22, 2023 · Synced Oct 23, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT04476030 live on ClinicalTrials.gov.