AGN-193408 SR in the Treatment of Open-angle Glaucoma or Ocular Hypertension
Public ClinicalTrials.gov record NCT04499248. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase 1/2 Study to Evaluate the Safety and Efficacy of AGN-193408 SR in Participants With Open-Angle Glaucoma or Ocular Hypertension
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
This is a multicenter, open-label, dose escalation (Cohort 1) to masked, randomized, parallel-groups (Cohort 2) and (Cohort 3) study to evaluate the safety and efficacy of AGN-193408 SR in participants with open-angle glaucoma or ocular hypertension
Study identification
- NCT ID
- NCT04499248
- Recruitment status
- Active, not recruiting
- Study type
- Interventional
- Phase
- Phase 1, Phase 2
- Enrollment
- 100 participants
Conditions and interventions
Conditions
Interventions
- AGN-193408 SR Drug
- Lumigan Other
- Sham Administration Other
- Lumigan Vehicle Other
Drug · Other
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Nov 15, 2020
- Primary completion
- Mar 31, 2029
- Completion
- Mar 31, 2029
- Last update posted
- May 21, 2026
2020 – 2029
United States locations
- U.S. sites
- 42
- U.S. states
- 21
- U.S. cities
- 41
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Horizon Eye Specialists & Lasik Center - Sun City /ID# 252153 | Sun City | Arizona | 85351 | — |
| Global Research Management /ID# 241699 | Glendale | California | 91204-2500 | — |
| United Medical Research Institute /ID# 241701 | Inglewood | California | 90301 | — |
| Lakeside Vision Center /ID# 241698 | Irvine | California | 92604 | — |
| The Eye Research Foundation /ID# 234528 | Newport Beach | California | 92663-3637 | — |
| Sacramento Eye Consultants /ID# 241697 | Sacramento | California | 95815 | — |
| Premiere Practice Management LLC /ID# 235957 | Torrance | California | 90505 | — |
| Wolstan & Goldberg Eye Associates /ID# 241700 | Torrance | California | 90505 | — |
| Connecticut Eye Consultants P.C. /ID# 235862 | Danbury | Connecticut | 06810 | — |
| Brandon Eye Associates - Brandon /ID# 276600 | Brandon | Florida | 33511 | — |
| Nature Coast Clinical Research - Crystal River /ID# 237781 | Crystal River | Florida | 34429 | — |
| Advanced Research, LLC /ID# 276987 | Deerfield Beach | Florida | 33064-1346 | — |
| University of Florida Health Ophthalmology - Jacksonville /ID# 243122 | Jacksonville | Florida | 32209-6533 | — |
| East Florida Eye Institute /ID# 235762 | Stuart | Florida | 34994 | — |
| Logan Ophthalmic Research Inc. /ID# 252087 | Tamarac | Florida | 33321 | — |
| Coastal Research Associates /ID# 234649 | Roswell | Georgia | 30076 | — |
| Thomas Eye Group PC /ID# 266775 | Sandy Springs | Georgia | 30328 | — |
| University of Illinois Hospital and Health Sciences System /ID# 253630 | Chicago | Illinois | 60607 | — |
| Midwest Medical Advisors Inc /ID# 235845 | Carmel | Indiana | 46290 | — |
| Indiana University - Glick Eye Institute /ID# 235887 | Indianapolis | Indiana | 46202 | — |
| Ophthalmic Consultants of Boston /ID# 236535 | Boston | Massachusetts | 02129 | — |
| Fraser Eye Care Center /ID# 267100 | Fraser | Michigan | 48026 | — |
| Midwest Vision Research Foundation at Pepose Vision Institute /ID# 267094 | Chesterfield | Missouri | 63017 | — |
| Silverstein Eye Centers /ID# 266767 | Kansas City | Missouri | 64133 | — |
| Tekwani Vision Center /ID# 235149 | St Louis | Missouri | 63128 | — |
| Nv Eye Surgery - Henderson /ID# 276925 | Henderson | Nevada | 89052 | — |
| Rutgers New Jersey Medical School Campus, Doctors Office Center /ID# 234365 | Newark | New Jersey | 07103-2425 | — |
| Northern New Jersey Eye Institute /ID# 241545 | South Orange | New Jersey | 07079 | — |
| Asheville Eye Associates /ID# 234963 | Asheville | North Carolina | 28803 | — |
| Private Practice - Dr. James D. Branch /ID# 234560 | Winston-Salem | North Carolina | 27101 | — |
| The Ohio State University /ID# 267590 | Columbus | Ohio | 43210 | — |
| Oklahoma Eye Surgeons /ID# 252089 | Oklahoma City | Oklahoma | 73112 | — |
| Drs Fine Hoffman & Sims LLC /ID# 235919 | Eugene | Oregon | 97401 | — |
| Scott and Christie and Associates /ID# 252284 | Cranberry Township | Pennsylvania | 16066 | — |
| Eye Specialty Group /ID# 252201 | Memphis | Tennessee | 38120 | — |
| Vanderbilt Eye Institute /ID# 266915 | Nashville | Tennessee | 37232-0025 | — |
| Advancing Vision Research /ID# 236683 | Smyrna | Tennessee | 37167 | — |
| Macro Trials (SMO/Network/Consortium) /ID# 266772 | Austin | Texas | 78731 | — |
| San Antonio Eye Center /ID# 272087 | San Antonio | Texas | 78215 | — |
| St. George Eye Center /ID# 236200 | St. George | Utah | 84790 | — |
| Piedmont Eye Center /ID# 246455 | Lynchburg | Virginia | 24502 | — |
| Vistar Eye Center /ID# 234811 | Roanoke | Virginia | 24011 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 7 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT04499248, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted May 21, 2026 · Synced Sep 9, 2026
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Open the official record
The complete protocol, eligibility criteria, and contact information for NCT04499248 live on ClinicalTrials.gov.