ClinicalTrials.gov record
ACTIV-3: Therapeutics for Inpatients With COVID-19
ClinicalTrials.gov ID: NCT04501978
Public ClinicalTrials.gov record NCT04501978. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Multicenter, Adaptive, Randomized, Blinded Controlled Trial of the Safety and Efficacy of Investigational Therapeutics for Hospitalized Patients With COVID-19
Study identification
- NCT ID
- NCT04501978
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 3
- Lead sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
- NIH
- Enrollment
- 2,753 participants
Conditions and interventions
Conditions
Interventions
- AZD7442 Biological
- BRII-196/BRII-198 Biological
- LY3819253 Biological
- MP0420 Drug
- PF-07304814 Drug
- Placebo Drug
- Remdesivir Biological
- VIR-7831 Biological
Biological · Drug
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Not listed
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Aug 3, 2020
- Primary completion
- Apr 5, 2022
- Completion
- Jul 13, 2023
- Last update posted
- Aug 24, 2023
2020 – 2023
United States locations
- U.S. sites
- 98
- U.S. states
- 32
- U.S. cities
- 67
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Banner University Medical Center Tucson (Site 206-004), 1625 N. Campbell Avenue | Tucson | Arizona | 85719 | — |
| Southern Arizona VA Healthcare System (Site 074-009), 3601 S. 6th Ave. | Tucson | Arizona | 85723 | — |
| Velocity Chula Vista (Site 080-034), 752 Medical Center Ct., Ste. 304 | Chula Vista | California | 91911 | — |
| Community Regional Medical Center (Site 203-005), 2823 Fresno Street | Fresno | California | 93701 | — |
| Velocity San Diego (Site 080-035), 5565 Grossmont Center Drive, Building 2, Suite 1 | La Mesa | California | 91942 | — |
| VA Loma Linda Healthcare System (Site 074-017), 11201 Benton Street | Loma Linda | California | 92357 | — |
| VA Long Beach Healthcare System (Site 074-026), 5901 East 7th Street (09/151-M2) | Long Beach | California | 90822 | — |
| Keck Hospital of USC (Site 301-020), 1500 San Pablo Street | Los Angeles | California | 90033 | — |
| Cedars-Sinai Medical Center (Site 208-002), 8700 Beverly Blvd. | Los Angeles | California | 90048 | — |
| Ronald Reagan UCLA Medical Center (Site 203-002), 757 Westwood Plaza | Los Angeles | California | 90095 | — |
| Sacramento VA Medical Center (Site 074-023), 10535 Hospital Way | Mather | California | 95655 | — |
| Hoag Memorial Hospital Presbyterian (Site 080-026), One Hoag Drive | Newport Beach | California | 92663 | — |
| Palo Alto VAMC (Site 074-005), 3801 Miranda Avenue | Palo Alto | California | 94304 | — |
| UC Davis Health (Site 203-004), 2315 Stockton Blvd. | Sacramento | California | 95817 | — |
| VA San Diego Healthcare System (Site 074-016), 3350 La Jolla Village Drive | San Diego | California | 92161 | — |
| UCSF Medical Center at Mount Zion (Site 203-007), 1600 Divisadero St. | San Francisco | California | 94115 | — |
| San Francisco VAMC (Site 074-002), 4150 Clement St. | San Francisco | California | 94121 | — |
| UCSF Medical Center (Site 203-001), Moffitt-Long Hospital, 505 Parnassus Ave. | San Francisco | California | 94143 | — |
| Stanford University Hospital & Clinics (Site 203-003), 300 Pasteur Dr. | Stanford | California | 94305 | — |
| Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center (Site 066-002), 1124 W. Carson Street, CDCRC Building | Torrance | California | 90502 | — |
| University of Colorado Hospital (Site 204-001), 12605 E. 16th Avenue | Aurora | Colorado | 80045 | — |
| Denver Public Health (Site 017-004), 660 Bannock St., MC2600 (Infectious Disease Clinic) | Denver | Colorado | 80204 | — |
| National Jewish Health / St. Joseph Hospital (Site 204-003), 1400 Jackson Street | Denver | Colorado | 80206 | — |
| West Haven VA Medical Center (Site 025-007), 950 Campbell Avenue | West Haven | Connecticut | 06516 | — |
| MedStar Georgetown University Hospital (Site 067-001), 3800 Reservoir Road NW | Washington D.C. | District of Columbia | 20007 | — |
| MedStar Health Research Institute (Site 009-021), MedStar Washington Hospital Center, 110 Irving St., NW. | Washington D.C. | District of Columbia | 20010 | — |
| Washington DC VA Medical Center (Site 009-004), 50 Irving Street NW | Washington D.C. | District of Columbia | 20422 | — |
| Bay Pines VAMC (Site 074-004), 10000 Bay Pines Blvd., Bldg. 100, Room 5B-104 | Bay Pines | Florida | 33744 | — |
| Baycare Health System (Site 301-025), Morton Plant Hospital, 300 Pinellas Street | Clearwater | Florida | 33756 | — |
| North Florida/South Georgia Veterans Health System (Site 074-011), 1601 SW. Archer Road | Gainesville | Florida | 32608-1197 | — |
| Memorial Healthcare System (Site 648-002), Memorial Regional Hospital, 3501 Johnson Street | Hollywood | Florida | 33021 | — |
| Miami VAMC (Site 074-003), 1201 NW 16 Street | Miami | Florida | 33125 | — |
| Hillsborough County Health Department, University of South Florida (Site 032-001) | Tampa | Florida | 33602 | — |
| Emory University (Site 301-008), The Emory Clinic, Bldg. A, Suite 2236, 1365 Clifton Rd., NE | Atlanta | Georgia | 30322 | — |
| Lutheran Medical Group (Site 301-010), 7916 W. Jefferson Boulevard | Fort Wayne | Indiana | 46804 | — |
| Cotton O'Neil Clinical Research Center (Site 080-030), Stormont Vail Health, 1500 SW 10th Avenue | Topeka | Kansas | 66604 | — |
| University of Kentucky Hospital (Site 210-004), 1000 South Limestone St. | Lexington | Kentucky | 40536 | — |
| Ochsner Clinic Foundation (Site 301-015), 1514 Jefferson Highway | New Orleans | Louisiana | 70121 | — |
| University of Maryland Medical Center (Site 301-019), 22 South Greene Street | Baltimore | Maryland | 21201 | — |
| Massachusetts General Hospital (Site 202-002), 55 Fruit Street | Boston | Massachusetts | 02114 | — |
| Beth Israel Deaconess Medical Center (Site 202-001), 330 Brookline Ave. | Boston | Massachusetts | 02215 | — |
| Baystate Medical Center (Site 201-001), 759 Chestnut Street | Springfield | Massachusetts | 01199 | — |
| University of Michigan (Site 205-001), 1500 East Medical Center Drive | Ann Arbor | Michigan | 48109 | — |
| Henry Ford Health System, Henry Ford Hospital (Site 014-001), 2799 W. Grand Blvd. | Detroit | Michigan | 48202 | — |
| Minneapolis Heart Institute Foundation (Site 301-026), Abbott Northwestern Hospital, 920 E 28th St. #100 | Minneapolis | Minnesota | 55407 | — |
| Hennepin Healthcare (Site 027-001), 701 Park Avenue | Minneapolis | Minnesota | 55415 | — |
| Minneapolis VA Health Care System (Site 105-001), 1 Veterans Drive, Bldg 70 | Minneapolis | Minnesota | 55417 | — |
| M Health Fairview University of Minnesota Medical Center (Site 112-001), 500 Harvard St. SE. | Minneapolis | Minnesota | 55455 | — |
| University of Mississippi Medical Center (Site 202-005), 2500 North State Street | Jackson | Mississippi | 39216 | — |
| VA St. Louis Healthcare System (Site 074-027), 915 North Grand Blvd., Rm. C201 | St Louis | Missouri | 63106 | — |
| Dartmouth-Hitchcock Medical Center/Mary Hitchcock Memorial Hospital (Site 301-024), One Medical Center Drive | Lebanon | New Hampshire | 03756 | — |
| Cooper University Hospital (Site 019-001), One Cooper Plaza | Camden | New Jersey | 08103 | — |
| SUNY Downstate Medical Center (Site 033-001), 450 Clarkson Ave. | Brooklyn | New York | 11203 | — |
| Maimonides Medical Center (Site 033-002), 4802 10th Avenue | Brooklyn | New York | 11219 | — |
| Ichan School of Medicine at Mount Sinai (Site 301-012), One Gustave L. Levy Place, Box 1620 | New York | New York | 10029 | — |
| Lincoln Medical Center (New York Health and Hospitals/Lincoln) (Site 003-016), 234 E. 149th Street | The Bronx | New York | 10451 | — |
| Montefiore Medical Center Weiler Hospital (Site 206-003), 1825 Eastchester Road | The Bronx | New York | 10461 | — |
| Montefiore Medical Center Moses Hospital (Site 206-001), 111 E. 210th Street | The Bronx | New York | 10467 | — |
| Duke University Hospital (Site 301-006), 2301 Erwin Road | Durham | North Carolina | 27710 | — |
| Wake Forest University Health Sciences (Site 210-001), Medical Center Blvd | Winston-Salem | North Carolina | 27157 | — |
| University of Cincinnati Medical Center (Site 207-003), 234 Goodman Ave. | Cincinnati | Ohio | 45219 | — |
| University Hospitals Cleveland Medical Center (Site 108-001), 11100 Euclid Avenue | Cleveland | Ohio | 44106 | — |
| Cleveland Clinic Fairview Hospital (Site 207-005), 18101 Lorain Avenue | Cleveland | Ohio | 44111 | — |
| Cleveland Clinic Foundation (Site 207-001), 9500 Euclid Avenue | Cleveland | Ohio | 44195 | — |
| Cleveland Clinic Marymount Hospital (Site 207-006), 12300 McCraken Road | Garfield Heights | Ohio | 44125 | — |
| Oregon Health & Science University (Site 208-003), 3181 SW Sam Jackson Park Rd. | Portland | Oregon | 97239-3098 | — |
| Portland VA Healthcare System (Site 074-024), 3710 SW. US Veterans Hospital Road | Portland | Oregon | 97239 | — |
| UPMC Magee-Womens Hospital (Site 209-003), 300 Halket Street | Pittsburgh | Pennsylvania | 15213 | — |
| UPMC Presbyterian Hospital (Site 209-001), 200 Lothrop Street | Pittsburgh | Pennsylvania | 15213 | — |
| UPMC Shadyside Hospital (Site 209-005), 5230 Centre Avenue | Pittsburgh | Pennsylvania | 15232 | — |
| Rhode Island Hospital (Site 080-036), 593 Eddy Street | Providence | Rhode Island | 02903 | — |
| The Miriam Hospital (Site 080-039), 164 Summit Ave. | Providence | Rhode Island | 02906 | — |
| VA Providence Healthcare System (Site 074-025), 830 Chalkstone Ave. | Providence | Rhode Island | 02908 | — |
| Ralph H. Johnson VA Medical Center (Site 074-015), 109 Bee Street | Charleston | South Carolina | 29401 | — |
| MUSC Research Nexus Clinic (Site 210-002), 96 Jonathan Lucas St., CSB 214 | Charleston | South Carolina | 29425 | — |
| MUSC Health Florence Medical Center (Site 210-006), 805 Pamplico Highway | Florence | South Carolina | 29505 | — |
| VA TVHS Nashville Campus (Site 074-022), 1310 24th Avenue South | Nashville | Tennessee | 37212 | — |
| Vanderbilt University Medical Center (Site 212-001), 1211 Medical Center Drive | Nashville | Tennessee | 37232 | — |
| Hendrick Medical Center (Site 080-014), 1900 Pine Street | Abilene | Texas | 79601 | — |
| CHRISTUS Spohn Shoreline Hospital (Site 080-001), 600 Elizabeth Street | Corpus Christi | Texas | 78404 | — |
| Parkland Health and Hospital Systems (Site 084-002), 5200 Harry Hines Blvd | Dallas | Texas | 75235 | — |
| UT Southwestern Medical Center (Site 084-001), 1936 Amelia Court, 2nd Floor | Dallas | Texas | 75235 | — |
| Baylor, Scott and White Health (Site 301-003), Baylor University Medical Center, 3500 Gaston Ave. | Dallas | Texas | 75246 | — |
| Memorial Hermann Hospital (Site 203-006), 6411 Fannin Street | Houston | Texas | 77030 | — |
| Michael E. DeBakey Veterans Affairs Medical Center (MEDV AMC) (Site 074-006), 2002 Holcombe Blvd. | Houston | Texas | 77030 | — |
| Texas Heart Institute (Site 301-017), 6770 Bertner, MC4-266 | Houston | Texas | 77030 | — |
| CHRISTUS Good Shepherd Medical Center (Site 080-031), 700 E. Marshall Ave. | Longview | Texas | 75601 | — |
| Intermountain Medical Center (Site 211-001), 5121 South Cottonwood Street | Murray | Utah | 84107 | — |
| University of Utah Hospital (Site 211-002), 419 Wakara Way, Suite 207 | Salt Lake City | Utah | 84108 | — |
| LDS Hospital (Site 211-004), 8th Ave. C Street | Salt Lake City | Utah | 84143 | — |
| University of Virginia Health Systems (Site 301-021), 1215 Lee Street | Charlottesville | Virginia | 22903 | — |
| Virginia Commonwealth University Health System (Site 210-005), 1250 East Marshall Street | Richmond | Virginia | 23298 | — |
| Carilion Roanoke Memorial Hospital (Site 080-018), 1906 Belleview Avenue | Roanoke | Virginia | 24014 | — |
| Salem VA Medical Center (Site 074-014), 1970 Roanoke Blvd. | Salem | Virginia | 24153 | — |
| Harborview Medical Center (Site 208-001), 325 9th Avenue | Seattle | Washington | 98104 | — |
| Swedish Hospital First Hill (Site 208-005), 747 Broadway | Seattle | Washington | 98122 | — |
| University of Washington Medical Center - Montlake (Site 208-006), 1959 NE Pacific Street | Seattle | Washington | 98195 | — |
| West Virginia University (Site 301-023), One Medical Center Drive | Morgantown | West Virginia | 26506 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 37 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT04501978, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Aug 24, 2023 · Synced Apr 22, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete protocol, eligibility criteria, and contact information for NCT04501978 live on ClinicalTrials.gov.