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Completed Phase 4 Interventional Results available

Accelerating COVID-19 Therapeutic Interventions and Vaccines 4 ACUTE

ClinicalTrials.gov ID: NCT04505774

Public ClinicalTrials.gov record NCT04505774. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

ClinicalTrials.gov public records Last synced Jul 22, 2026, 6:38 PM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Official title

A Multicenter, Adaptive, Randomized Controlled Platform Trial of the Safety and Efficacy of Antithrombotic and Additional Strategies in Hospitalized Adults With COVID-19

Study identification

NCT ID
NCT04505774
Recruitment status
Completed
Study type
Interventional
Phase
Phase 4
Lead sponsor
Matthew Neal MD
Other
Enrollment
3,591 participants

Conditions and interventions

Conditions

Interventions

  • theraputic heparin Drug
  • prophylactic heparin Drug
  • P2Y12 Drug
  • Crizanlizumab Injection Drug
  • SGLT2 inhibitor Drug

Drug

Eligibility (public fields only)

Age range
18 Years and older
Sex
All
Healthy volunteers
Healthy volunteers not accepted

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date
Sep 3, 2020
Primary completion
Aug 30, 2023
Completion
Jan 25, 2024
Last update posted
Dec 29, 2024

2020 – 2024

United States locations

U.S. sites
81
U.S. states
33
U.S. cities
68
Facility City State ZIP Site status
University of Alabama Birmingham Alabama 35233
University of Arizona Tucson Arizona 85719
University of Arkansas for Medical Sciences Little Rock Arkansas 72205
Kaiser Permanente Fontana Fontana California 92335
Kaiser Permanente Los Angeles Los Angeles California 90027
Smidt Heart Institute at Cedars-Sinai Los Angeles California 90048
Ronald Reagan UCLA Medical Center Los Angeles California 90095
UC San Diego Hillcrest San Diego California 92103
Zuckerberg San Francisco General Hospital San Francisco California 94110
UCSF San Francisco San Francisco California 94143
Zuckerberg San Francisco General Hospital San Francisco California 94410
Stanford University Medical Center Stanford California 94305
Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center Torrance California 90502
Denver Health and Hospital Authority Denver Colorado 80401
St. Mary's Hospital & Regional Medical Center Grand Junction Colorado 81501
Saint Francis Hospital and Medical Center Hartford Connecticut 06105
University of Florida Gainesville Florida 32608
Memorial Hospital Jacksonville Florida 32216
AdventHealth Tampa Tampa Florida 33613
Emory Atlanta Georgia 30308
Morehouse School of Medicine Atlanta Georgia 30310
Queens Medical Center Honolulu Hawaii 96813
Memorial Hospital Belleville Illinois 62226
Cook County Health Chicago Illinois 60612
University of Illinois at Chicago Health (UIH) Chicago Illinois 60612
OSF Little Company of Mary Medical Center (OSF LCM) Evergreen Park Illinois 60805
Indiana University Health Methodist Hospital Indianapolis Iowa 46202
Kansas University Medical Center Kansas City Kansas 66160
Ochsner Clinic Foundation New Orleans Louisiana 70121
Boston University Boston Massachusetts 02118
St Elizabeth's Medical Center Brighton Massachusetts 02135
Baystate Medical Center Springfield Massachusetts 01199
University of Massachusetts Worcester Massachusetts 01655
University of Michigan Ann Arbor Michigan 48109
Wayne State University Detroit Michigan 48201
Hennepin County Medical Center Minneapolis Minnesota 55415
University of Mississippi Medical Center Jackson Mississippi 39216
Washington University School of Medicine, ACCS Research St Louis Missouri 63110
University Medical Center of Southern Nevada Las Vegas Nevada 89102
Cooper Health Camden New Jersey 08103
Englewood Health Englewood New Jersey 07631
Atlantic Health System Morristown New Jersey 07960
Rutgers New Jersey Medical School Newark New Jersey 07103
AtlantiCare Regional Medical Center Pomona New Jersey 08240
Albany Medical College Albany New York 12208
Mercy Hospital Buffalo Buffalo New York 14220
VA New York Harbor Healthcare System New York New York 10010
NYU Langone New York New York 10016
Mt. Sinai Hospital New York New York 10029
SUNY Upstate University Hospital Syracuse New York 13210
Jacobi Medical Center The Bronx New York 10461
Montefiore Medical Center The Bronx New York 10461
Westchester Medical Center Valhalla New York 10595
Duke University Hospital Durham North Carolina 27704
Wake Forest Winston-Salem North Carolina 27157
Cleveland Clinic Akron General Akron Ohio 44307
University of Cincinnati Medical Center Cincinnati Ohio 45219
The MetroHealth System Cleveland Ohio 44109
Cleveland Clinic Foundation Cleveland Ohio 44195
Ohio State Universtiy Wexner Medical Center Columbus Ohio 43210
Mercy Health St Vincent Medical Center Toledo Ohio 43608
Ascension St. John Clinical Research Institute Tulsa Oklahoma 74104
Oregon Health and Science University Portland Oregon 97239
Geisinger Research Danville Pennsylvania 17822
Doylestown Cardiology Associates Doylestown Pennsylvania 18901
Penn State Health Milton S. Hershey Medical Center Hershey Pennsylvania 17033
Hospital of the University of Pennsylvania Philadelphia Pennsylvania 19104
Temple University Philadelphia Pennsylvania 19141
UPMC Presbyterian Pittsburgh Pennsylvania 15260
Rhode Island Hospital Providence Rhode Island 02903
The Miriam Hospital Providence Rhode Island 02906
Sarah Cannon and HCA Research Institute Nashville Tennessee 37203
Skyline Medical Center Nashville Tennessee 37207
University of Texas at Austin Austin Texas 78701
University of Texas Southwestern Medical Center Dallas Texas 75390
Medical City Ft Worth Fort Worth Texas 76104
Baylor Scott and White Medical Center - Temple Temple Texas 76508
HCA Henrico Doctors Hospital Richmond Virginia 23229
Swedish Hospital Seattle Washington 98122
West Virginia University CTR Morgantown West Virginia 26506
University of Wisconsin Hospital; Meriter Hospital (UW affiliated) Madison Wisconsin 53715

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

Non-U.S. locations

This page focuses on the U.S. directory. The official record also lists 20 non-U.S. sites.

About this trial record page

What this page shows
Public field values for ClinicalTrials.gov record NCT04505774, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do
No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from
Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh
Last update posted Dec 29, 2024 · Synced Jul 22, 2026

Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.

Open the official record

The complete protocol, eligibility criteria, and contact information for NCT04505774 live on ClinicalTrials.gov.

View official ClinicalTrials.gov record →