Efficacy and Safety of GMRx2 Compared to Dual Combinations for the Treatment of Hypertension
Public ClinicalTrials.gov record NCT04518293. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
Efficacy and Safety of GMRx2 (a Single Pill Combination Containing Telmisartan/Amlodipine/Indapamide) Compared to Dual Combinations for the Treatment of Hypertension
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
Recent hypertension guidelines recommend combination therapy as initial treatment for many or most patients. Several trials suggest triple low-dose combination therapy may be highly effective in terms of achieving blood pressure (BP) control without increasing adverse effects. This trial is designed to investigate the efficacy and safety of GMRx2 in participants with high blood pressure compared to dual combinations.
Study identification
- NCT ID
- NCT04518293
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 1,385 participants
Conditions and interventions
Conditions
Interventions
- Telmisartan 20 mg/amlodipine 2.5 mg/indapamide 1.25 mg Drug
- telmisartan 40 mg/amlodipine 5 mg/indapamide 2.5 mg Drug
- Telmisartan 20 mg/amlodipine 2.5 mg Drug
- telmisartan 40 mg/amlodipine 5 mg Drug
- Telmisartan 20 mg/indapamide 1.25 mg Drug
- telmisartan 40 mg/indapamide 2.5 mg Drug
- Amlodipine 2.5 mg/indapamide 1.25 mg Drug
- amlodipine 5 mg/indapamide 2.5 mg Drug
Drug
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Jul 9, 2021 (Actual)
- Primary completion
- Aug 11, 2023 (Actual)
- Completion
- Sep 1, 2023 (Actual)
- Last update posted
- Jun 3, 2025
2021 – 2023
United States locations
- U.S. sites
- 31
- U.S. states
- 11
- U.S. cities
- 27
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Elite Clinical Studies | Phoenix | Arizona | 85018 | — |
| Headlands Research | Scottsdale | Arizona | 85260 | — |
| Quality of Life Medical & Research Associates | Tucson | Arizona | 85712 | — |
| Valiance Clinical Research | South Gate | California | 90280 | — |
| Valiance Clinical Research | Tarzana | California | 91356 | — |
| Clinical Research of Brandon | Brandon | Florida | 33511 | — |
| Inpatient Research Clinic | Hialeah | Florida | 33013 | — |
| Multi-Speciality Research Associates | Lake City | Florida | 32055 | — |
| Suncoast Research Group | Miami | Florida | 33135 | — |
| New Horizon Research Center | Miami | Florida | 33165 | — |
| Ocala Research Institute | Ocala | Florida | 34471 | — |
| Suncoast Research Associates | St. Petersburg | Florida | 33173 | — |
| Accel Research | St. Petersburg | Florida | 33709 | — |
| Precision Research Center | Tampa | Florida | 33603 | — |
| Meridian Clinical Research | Savannah | Georgia | 31406 | — |
| Buckhead Primary Care Research | Snellville | Georgia | 30078 | — |
| Loyola University | Maywood | Illinois | 60153 | — |
| Meridian Clinical Research | Baton Rouge | Louisiana | 70809 | — |
| Meridian Clinical Research | Endwell | New York | 13760 | — |
| Javarra Research | Charlotte | North Carolina | 28210 | — |
| East Carolina University | Greenville | North Carolina | 27834 | — |
| The University of Tennessee Health Science Center | Memphis | Tennessee | 38105 | — |
| ACRC Trials - Southwest Medical Village | Austin | Texas | 78735 | — |
| ACRC Trials - Premier Family Physicians | Austin | Texas | 78746 | — |
| ACRC Trials - Family Medicine Associates of Texas | Carlton | Texas | 75010 | — |
| Synergy Groups Medical | Houston | Texas | 77036 | — |
| Synergy Groups Medical | Houston | Texas | 77087 | — |
| Synergy Groups Medical | Missouri City | Texas | 77459 | — |
| North Hills Medical Research | North Richland Hills | Texas | 76180 | — |
| ACRC Trials - Village Health Partners | Plano | Texas | 75093 | — |
| Meridian Clinical Research | Portsmouth | Virginia | 23703 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 58 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT04518293, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Jun 3, 2025 · Synced Oct 19, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT04518293 live on ClinicalTrials.gov.