ClinicalTrials.gov record
A Study of Tucatinib Plus Trastuzumab Deruxtecan in HER2+ Breast Cancer
ClinicalTrials.gov ID: NCT04539938
Public ClinicalTrials.gov record NCT04539938. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
ClinicalTrials.gov public records Last synced May 11, 2026, 4:40 PM EDT
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Single Arm, Open Label Phase 2 Study of Tucatinib in Combination With Trastuzumab Deruxtecan in Subjects With Previously Treated Unresectable Locally-Advanced or Metastatic HER2+ Breast Cancer
Study identification
- NCT ID
- NCT04539938
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 2
- Lead sponsor
- Seagen, a wholly owned subsidiary of Pfizer
- Industry
- Enrollment
- 70 participants
Conditions and interventions
Conditions
Interventions
- trastuzumab deruxtecan Drug
- tucatinib Drug
Drug
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Nov 30, 2020
- Primary completion
- Jul 14, 2024
- Completion
- Mar 6, 2025
- Last update posted
- Mar 22, 2026
2020 – 2025
United States locations
- U.S. sites
- 140
- U.S. states
- 20
- U.S. cities
- 95
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| University Of Alabama at Birmingham | Birmingham | Alabama | 35233 | — |
| University of Alabama at Birmingham, IDS Pharmacy | Birmingham | Alabama | 35249 | — |
| University Of Alabama at Birmingham | Birmingham | Alabama | 35249 | — |
| Arizona Oncology Associates, PC - HOPE | Tucson | Arizona | 85704 | — |
| Arizona Oncology Associates, PC - HOPE | Tucson | Arizona | 85711 | — |
| UCLA Hematology/Oncology - Alhambra | Alhambra | California | 91801 | — |
| UCLA Hematology/Oncology - Burbank | Burbank | California | 91505 | — |
| City of Hope (City of Hope National Medical Center, City of Hope Medical center) | Duarte | California | 91010 | — |
| City of Hope Investigational Drug Services (IDS) | Duarte | California | 91010 | — |
| UCLA Hematology/Oncology - Laguna Hills | Laguna Hills | California | 92653 | — |
| (IRB# 20-001502) Ronald Reagan UCLA Medical Center, Drug Information Center | Los Angeles | California | 90095 | — |
| UCLA Hematology/Oncology | Los Angeles | California | 90095 | — |
| UCLA Hematology/Oncology - Pasadena | Pasadena | California | 91105 | — |
| Zuckerberg San Francisco General Hospital- Breast Clinic | San Francisco | California | 94110 | — |
| Zuckerberg San Francisco General Hospital- Oncology Clinic | San Francisco | California | 94110 | — |
| University of California, San Francisco (UCSF) Helen Diller Family Comprehensive Cancer Center | San Francisco | California | 94158 | — |
| UCLA Hematology/Oncology - San Luis Obispo | San Luis Obispo | California | 93401 | — |
| UCLA Hematology/Oncology - Santa Barbara | Santa Barbara | California | 93105 | — |
| UCLA Hematology/Oncology - Santa Monica | Santa Monica | California | 90404 | — |
| UCLA Hematology/Oncology Parkside | Santa Monica | California | 90404 | — |
| UCLA Hematology/Oncology - Ventura | Ventura | California | 93003 | — |
| UCLA Hematology/Oncology - Westlake | Westlake Village | California | 91361 | — |
| University of Colorado Denver CTO/CTRC - Outpatient. | Aurora | Colorado | 80045 | — |
| University of Colorado Hospital - Anschutz Cancer Pavilion (ACP) | Aurora | Colorado | 80045 | — |
| University of Colorado Hospital - Anschutz Inpatient Pavilion (AIP) | Aurora | Colorado | 80045 | — |
| University of Colorado Hospital - Anschutz Outpatient Pavilion (AOP) | Aurora | Colorado | 80045 | — |
| UC Health Lone Tree Medical Center | Lone Tree | Colorado | 80124 | — |
| Georgetown University Medical Center | Washington D.C. | District of Columbia | 20007 | — |
| Washington Cancer Institute at MedStar Washington Hospital Center | Washington D.C. | District of Columbia | 20010 | — |
| Florida Cancer Specialists | Altamonte Springs | Florida | 32701 | — |
| Florida Cancer Specialists | Brandon | Florida | 33511 | — |
| Florida Cancer Specialists | Clearwater | Florida | 33761 | — |
| Florida Cancer Specialists | Gainesville | Florida | 32605 | — |
| Florida Cancer Specialists | Largo | Florida | 33770 | — |
| Florida Cancer Specialists | Lecanto | Florida | 34461 | — |
| Florida Cancer Specialists | Ocala | Florida | 34474 | — |
| Florida Cancer Specialists | Orange City | Florida | 32763 | — |
| Florida Cancer Specialists | Orlando | Florida | 32806 | — |
| Florida Cancer Specialists | St. Petersburg | Florida | 33705 | — |
| Florida Cancer Specialists | Tampa | Florida | 33607 | — |
| Florida Cancer Specialists | Tavares | Florida | 32778 | — |
| Florida Cancer Specialists | The Villages | Florida | 32159 | — |
| Florida Cancer Specialists | Trinity | Florida | 34655 | — |
| Florida Cancer Specialists | Winter Park | Florida | 32789 | — |
| Northside Hospital, Inc - GCS/Athens | Athens | Georgia | 30606 | — |
| Winship Cancer Institute @ Emory University Hospital Midtown | Atlanta | Georgia | 30308 | — |
| Emory University Hospital | Atlanta | Georgia | 30322 | — |
| The Emory Clinic | Atlanta | Georgia | 30322 | — |
| Winship Cancer Institute / Emory University School of Medicine | Atlanta | Georgia | 30322 | — |
| Winship Cancer Institute | Atlanta | Georgia | 30322 | — |
| Atlanta Cancer Care - Atlanta | Atlanta | Georgia | 30342 | — |
| Northside Hospital, Inc. - Central Research Department | Atlanta | Georgia | 30342 | — |
| Northside Hospital, Inc. - GCS/Center Pointe | Atlanta | Georgia | 30342 | — |
| Northside Hospital, Inc - GCS/Blairsville | Blairsville | Georgia | 30512 | — |
| Northside Hospital, Inc - GCS/Canton | Canton | Georgia | 30114 | — |
| Atlanta Cancer Care - Cumming | Cumming | Georgia | 30041 | — |
| Northside Hospital, Inc. - GCS/Decatur | Decatur | Georgia | 30033 | — |
| NHCI Suburban Hematology-oncology Associates - Duluth | Duluth | Georgia | 30096 | — |
| NHCI Suburban Hematology-oncology Associates - lawrenceville | Lawrenceville | Georgia | 30046 | — |
| Northside Hospital, Inc - GCS/Macon | Macon | Georgia | 31217 | — |
| Northside Hospital, Inc. - GCS/Marietta | Marietta | Georgia | 30060 | — |
| Atlanta Cancer Care - Stockbridge | Stockbridge | Georgia | 30281 | — |
| Harry and Jeanette Weinberg Cancer Institute at Franklin Square | Baltimore | Maryland | 21237 | — |
| Brigham and Women's Hospital | Boston | Massachusetts | 02115 | — |
| Dana-Farber Cancer Institute | Boston | Massachusetts | 02215 | — |
| Dana Farber Cancer Institute- Chestnut Hill | Newton | Massachusetts | 02459 | — |
| Mercy Hospital | Coon Rapids | Minnesota | 55433 | — |
| Minnesota Oncology Hematology, PA | Coon Rapids | Minnesota | 55433 | — |
| Mercy Hospital - Unity Campus | Fridley | Minnesota | 55432 | — |
| Minnesota Oncology Hematology, PA | Fridley | Minnesota | 55433 | — |
| Minnesota Oncology Hematology, PA | Minneapolis | Minnesota | 55404 | — |
| Abbott Northwestern Hospital | Minneapolis | Minnesota | 55407 | — |
| Allina Health Cancer institute | Minneapolis | Minnesota | 55407 | — |
| Mayo Clinic | Rochester | Minnesota | 55905 | — |
| Allina Health Cancer Institute | Saint Paul | Minnesota | 55102 | — |
| Minnesota Oncology Hematology PA | Saint Paul | Minnesota | 55102 | — |
| Minnesota Oncology Hematology, PA | Saint Paul | Minnesota | 55102 | — |
| United Hospital | Saint Paul | Minnesota | 55102 | — |
| Oncology Hematology West, PC dba Nebraska Cancer Specialists | Omaha | Nebraska | 68114 | — |
| Oncology Hematology West, PC dba Nebraska Cancer Specialists | Omaha | Nebraska | 68124 | — |
| Oncology Hematology West, PC dba Nebraska Cancer Specialists | Omaha | Nebraska | 68130 | — |
| Oncology Hematology West, PC dba Nebraska Cancer Specialists | Papillion | Nebraska | 68046 | — |
| MSK Basking Ridge | Basking Ridge | New Jersey | 07920 | — |
| Hackensack University Medical Center | Hackensack | New Jersey | 07601 | — |
| MSK Monmouth | Middletown | New Jersey | 07748 | — |
| MSK Bergen | Montvale | New Jersey | 07645 | — |
| MSK Commack | Commack | New York | 11725 | — |
| MSK Westchester | Harrison | New York | 10604 | — |
| Memorial Sloan Kettering Cancer Center - Investigational Drug Service Pharmacy | Long Island City | New York | 11101 | — |
| Evelyn H. Lauder Breast and Imaging Center (BAIC). | New York | New York | 10065 | — |
| MSK Nassau | Uniondale | New York | 11553 | — |
| Providence Cancer Institute Franz Clinic | Portland | Oregon | 97213 | — |
| Providence Portland Medical Center | Portland | Oregon | 97213 | — |
| UPMC Hillman Cancer Center Passavant North | Cranberry Township | Pennsylvania | 16066 | — |
| UPMC Hillman Cancer Center Erie | Erie | Pennsylvania | 16505 | — |
| UPMC Hillman Cancer Center Mountainview | Greensburg | Pennsylvania | 15601 | — |
| UPMC Hillman Cancer Center UPMC East | Monroeville | Pennsylvania | 15146 | — |
| UPMC Hillman Cancer Center Upper Saint Clair | Pittsburgh | Pennsylvania | 15102 | — |
| Magee-Womens Hospital of UPMC | Pittsburgh | Pennsylvania | 15213 | — |
| University of Pittsburgh Cancer Institute Investigational Drug Service UPMC Hillman Cancer Center | Pittsburgh | Pennsylvania | 15232 | — |
| UPMC Cancer Centers William M. Cooper Ambulatory Care Pavilion of the Hillman Cancer Center | Pittsburgh | Pennsylvania | 15232 | — |
| UPMC Hillman Cancer Center UPMC Passavant | Pittsburgh | Pennsylvania | 15237 | — |
| UPMC Hillman Cancer Center Uniontown | Uniontown | Pennsylvania | 15401 | — |
| UPMC Hillman Cancer Center Washington | Washington | Pennsylvania | 15301 | — |
| Tennessee Oncology, PLLC | Chattanooga | Tennessee | 37403 | — |
| Sarah Cannon Research Institute | Chattanooga | Tennessee | 37404 | — |
| Tennessee Oncology, PLLC | Chattanooga | Tennessee | 37404 | — |
| Tennessee Oncology, PLLC | Cleveland | Tennessee | 37311 | — |
| Tennessee Oncology, PLLC | Dickson | Tennessee | 37055 | — |
| Tennessee Oncology, PLLC | Franklin | Tennessee | 37067 | — |
| Tennessee Oncology, PLLC | Gallatin | Tennessee | 37066 | — |
| Tennessee Oncology, PLLC | Hendersonville | Tennessee | 37075 | — |
| Tennessee Oncology, PLLC | Hermitage | Tennessee | 37076 | — |
| Tennessee Oncology, PLLC | Lebanon | Tennessee | 37909 | — |
| Tennessee Oncology, PLLC | Murfreesboro | Tennessee | 37129 | — |
| Tennessee Oncology, PLLC | Nashville | Tennessee | 37203 | — |
| The Sarah Cannon Research Institute | Nashville | Tennessee | 37203 | — |
| Tennessee Oncology, PLLC | Nashville | Tennessee | 37205 | — |
| Tennessee Oncology, PLLC | Nashville | Tennessee | 37207 | — |
| Tennessee Oncology, PLLC | Nashville | Tennessee | 37211 | — |
| Tennessee Oncology, PLLC | Shelbyville | Tennessee | 37160 | — |
| Tennessee Oncology, PLLC | Smyrna | Tennessee | 37167 | — |
| The University of Texas M.D. Anderson Cancer Center | Houston | Texas | 77030 | — |
| U.T. MD Anderson Cancer Center | Houston | Texas | 77030 | — |
| US Oncology Investigational Product Center (IPC) | Irving | Texas | 75063 | — |
| US Oncology Investigational Products Center (IPC) | Irving | Texas | 75063 | — |
| US Oncology lnvestigational Products Center (IPC) | Irving | Texas | 75063 | — |
| Oncology & Hematology Associates of Southwest Virginia, Inc. D.B.A Blue Ridge Cancer Care | Blacksburg | Virginia | 24060 | — |
| Virginia Cancer Specialists, PC | Fairfax | Virginia | 22031 | — |
| Virginia Cancer Specialists, PC | Gainesville | Virginia | 20155 | — |
| Virginia Cancer Specialists, PC | Leesburg | Virginia | 20176 | — |
| Oncology & Hematology Associates of Southwest Virginia, Inc. D.B.A Blue Ridge Cancer Care | Low Moor | Virginia | 24457 | — |
| Virginia Cancer Specialists, PC | Reston | Virginia | 20190 | — |
| Oncology & Hematology Associates of Southwest Virginia, Inc. D.B.A Blue Ridge Cancer Care | Roanoke | Virginia | 24014 | — |
| Oncology & Hematology Associates of Southwest Virginia, Inc. D.B.A Blue Ridge Cancer Care | Salem | Virginia | 24153 | — |
| Oncology & Hematology Associates of Southwest Virginia, Inc. D.B.A Blue Ridge Cancer Care | Wytheville | Virginia | 24382 | — |
| Fred Hutchinson Cancer Center | Seattle | Washington | 98109 | — |
| University of Washington Medical Center | Seattle | Washington | 98195 | — |
| UW Health Oncology - One South Park | Madison | Wisconsin | 53715 | — |
| University of Wisconsin Clinical Science Center | Madison | Wisconsin | 53792 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT04539938, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Mar 22, 2026 · Synced May 11, 2026
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Open the official record
The complete protocol, eligibility criteria, and contact information for NCT04539938 live on ClinicalTrials.gov.