Flexible-Dose, Adjunctive Therapy Trial in Adults With Parkinson's Disease With Motor Fluctuations (TEMPO-3)
Public ClinicalTrials.gov record NCT04542499. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase 3, Double-Blind, Randomized, Placebo-Controlled, Parallel-Group, Flexible-Dose, 27-Week Trial to Evaluate the Efficacy, Safety, and Tolerability of Tavapadon as Adjunctive Therapy for Parkinson's Disease in Levodopa-Treated Adults With Motor Fluctuations (TEMPO-3 Trial)
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
The purpose of this study is to assess the effect of tavapadon on the change from baseline in total daily hours of "on" time without troublesome dyskinesia in L-Dopa-treated participants with Parkinson's Disease (PD) who are experiencing motor fluctuations.
Study identification
- NCT ID
- NCT04542499
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 507 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 40 Years to 80 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Sep 23, 2020 (Actual)
- Primary completion
- Jan 29, 2024 (Actual)
- Completion
- Feb 15, 2024 (Actual)
- Last update posted
- Apr 4, 2025
2020 – 2024
United States locations
- U.S. sites
- 54
- U.S. states
- 22
- U.S. cities
- 51
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Pheonix, Arizona | Phoenix | Arizona | 85004 | — |
| Little Rock, Arkansas | Little Rock | Arkansas | 72205 | — |
| Fountain Valley, California | Fountain Valley | California | 92708 | — |
| Fresno, California | Fresno | California | 93710 | — |
| Long beach, California | Long Beach | California | 90806 | — |
| Los Angeles, California | Los Angeles | California | 90048 | — |
| Pasadena, California | Pasadena | California | 91105 | — |
| Reseda, California | Reseda | California | 91335 | — |
| Denver, Colorado | Denver | Colorado | 80210 | — |
| Englewood, Colorado | Englewood | Colorado | 80113 | — |
| Adventura, Florida | Adventura | Florida | 33180 | — |
| Atlantis, Florida | Atlantis | Florida | 33462 | — |
| Boca Raton, Florida | Boca Raton | Florida | 33486 | — |
| Boca Raton, Florida | Boca Raton | Florida | 33487 | — |
| Coral Springs, Florida | Coral Springs | Florida | 33067 | — |
| Hallandale Beach, Florida | Hallandale | Florida | 33009 | — |
| Maitland, Florida | Maitland | Florida | 32751 | — |
| Ocala, Florida | Ocala | Florida | 34470 | — |
| Port Charlotte, Florida | Port Charlotte | Florida | 33980 | — |
| Port Orange, Florida | Port Orange | Florida | 32127 | — |
| Tampa, Florida | Tampa | Florida | 33615 | — |
| Winter Park, Florida | Winter Park | Florida | 32792 | — |
| Augusta, Georgia | Augusta | Georgia | 30912 | — |
| Chicago, Illinois | Chicago | Illinois | 60612 | — |
| Elk Grove Village, Illinois | Elk Grove Village | Illinois | 60007 | — |
| Kansas City, Kansas | Kansas City | Kansas | 66160 | — |
| Lexington, Kentucky | Lexington | Kentucky | 40536 | — |
| Scarborough, Maine | Scarborough | Maine | 04074 | — |
| Boston, Massachusettes | Boston | Massachusetts | 02215 | — |
| Boston Neuro Research Center | North Dartmouth | Massachusetts | 02747 | — |
| Farmington Hills, Michigan | Farmington Hills | Michigan | 48334 | — |
| West Bloomfield, Michigan | West Bloomfield | Michigan | 48322 | — |
| Saint Louis, Missouri | St Louis | Missouri | 63110 | — |
| Las Vegas, Nevada | Las Vegas | Nevada | 89106 | — |
| Las Vegas, Nevada | Las Vegas | Nevada | 89118 | — |
| Syracuse, New York | Syracuse | New York | 13210 | — |
| Asheville, North Carolina | Asheville | North Carolina | 28806 | — |
| Cincinnati, Ohio | Cincinnati | Ohio | 45212 | — |
| Cleveland, Ohio | Cleveland | Ohio | 44195 | — |
| Columbus, Ohio | Columbus | Ohio | 43221 | — |
| Dayton, Ohio | Dayton | Ohio | 45459 | — |
| Toledo, Ohio | Toledo | Ohio | 43614 | — |
| Memphis, Tennessee | Memphis | Tennessee | 38157 | — |
| Cypress, Texas | Cypress | Texas | 77429 | — |
| Georgetown, Texas | Georgetown | Texas | 78628 | — |
| Houston, Texas | Houston | Texas | 77030 | — |
| Lubbock, Texas | Lubbock | Texas | 79410 | — |
| Round Rock, Texas | Round Rock | Texas | 78681 | — |
| Burlington, Vermont | Burlington | Vermont | 05401 | — |
| Richmond, Virginia | Richmond | Virginia | 23229 | — |
| Richmond, Virginia | Richmond | Virginia | 23233 | — |
| Virginia Beach, Virginia | Virginia Beach | Virginia | 23456 | — |
| Kirkland, Washington | Kirkland | Washington | 98034 | — |
| Spokane, Washington | Spokane | Washington | 99202 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 92 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT04542499, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Apr 4, 2025 · Synced Oct 30, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT04542499 live on ClinicalTrials.gov.