A Study to Evaluate the Efficacy, Safety and Pharmacokinetics (PK) of a Higher Dose of Ocrelizumab in Adults With Primary Progressive Multiple Sclerosis (PPMS)
Public ClinicalTrials.gov record NCT04548999. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase IIIB Multicenter, Randomized, Double-blind, Controlled Study to Evaluate the Efficacy, Safety and Pharmacokinetics of a Higher Dose of Ocrelizumab in Adults With Primary Progressive Multiple Sclerosis
Study identification
- NCT ID
- NCT04548999
- Recruitment status
- Active, not recruiting
- Study type
- Interventional
- Phase
- Phase 3
- Lead sponsor
- Hoffmann-La Roche
- Industry
- Enrollment
- 769 participants
Conditions and interventions
Conditions
Interventions
- Ocrelizumab Drug
- Antihistamine Drug
- Methylprednisolone Drug
Drug
Eligibility (public fields only)
- Age range
- 18 Years to 55 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Dec 2, 2020
- Primary completion
- Jun 29, 2025
- Completion
- Sep 7, 2027
- Last update posted
- Mar 29, 2026
2020 – 2027
United States locations
- U.S. sites
- 24
- U.S. states
- 16
- U.S. cities
- 24
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Alabama Neurology Associates | Homewood | Alabama | 35209 | — |
| 21st Century Neurology | Phoenix | Arizona | 85004 | — |
| University of California Irvine | Irvine | California | 92697 | — |
| Stanford University Medical Center | Stanford | California | 94305 | — |
| University of Colorado Denver | Aurora | Colorado | 80045 | — |
| Advanced Neurosciences Research LLC | Fort Collins | Colorado | 80524 | — |
| MS and Neuromuscular Center of Excellence | Clearwater | Florida | 33761 | — |
| University of South Florida | Tampa | Florida | 33612 | — |
| Baptist Health Lexington | Nicholasville | Kentucky | 40356 | — |
| International Neurorehabilitation Institute | Lutherville | Maryland | 21093 | — |
| Massachusetts General Hospital. | Boston | Massachusetts | 02114 | — |
| University of Massachusetts Medical School | Worcester | Massachusetts | 01655 | — |
| Michigan Institute for Neurological Disorders | Farmington Hills | Michigan | 48334 | — |
| Washington University School of Medicine | St Louis | Missouri | 63110 | — |
| Jersey Shore University Medical Centre | Neptune City | New Jersey | 07753 | — |
| Northwell Health | Great Neck | New York | 11021 | — |
| Lenox Hill Hospital | New York | New York | 10075 | — |
| Cleveland Clinic | Cleveland | Ohio | 44195 | — |
| Neurology Clinic PC | Cordova | Tennessee | 38018 | — |
| Advanced Neurosciences Institute | Nashville | Tennessee | 37205 | — |
| University of Texas Southwestern Medical Center | Dallas | Texas | 75390 | — |
| Lone Star Neurology of San Antonio | San Antonio | Texas | 78258 | — |
| Texas Institute for Neurological Disorders | Sherman | Texas | 75092 | — |
| Wheaton Franciscan Healthcare - St. Francis Outpatient Center | Milwaukee | Wisconsin | 53215 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 125 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT04548999, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Mar 29, 2026 · Synced Jul 22, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete protocol, eligibility criteria, and contact information for NCT04548999 live on ClinicalTrials.gov.