A Research Study to Compare a Medicine Called Semaglutide Against Placebo in People With Peripheral Arterial Disease and Type 2 Diabetes
Public ClinicalTrials.gov record NCT04560998. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
All trial information on this site comes from the official ClinicalTrials.gov public API (clinicaltrials.gov/api/v2), run by the U.S. National Library of Medicine. We only display that public information; we do not add opinions, endorsements, or any other intent. Always review the official ClinicalTrials.gov record for the latest information.
Official title
Effects of Semaglutide on Functional Capacity in Patients With Type 2 Diabetes and Peripheral Arterial Disease
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
This study is done to see if semaglutide has an effect on walking ability compared with placebo (dummy medicine) in people with peripheral arterial disease (PAD) and type 2 diabetes. Participants will either get semaglutide or placebo ("dummy") medicine - which treatment participants get is decided by chance. Semaglutide is a medicine for type 2 diabetes that can be prescribed by doctors in some countries. Participants will get the study medicine (semaglutide or placebo) in a pre-filled pen for injection. Participants must inject it once a week into the stomach area, thigh, or upper arm, at any time of the day. The study will last for about 59 weeks. Participants will have 8 clinic visits and 1 phone call with the study doctor. At some clinic visits, participants will have blood tests. At some visits participants will also do a treadmill test to measure how far they can walk. Women cannot take part if pregnant, breast-feeding or planning to become pregnant during the study period.
Study identification
- NCT ID
- NCT04560998
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 792 participants
Conditions and interventions
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Oct 1, 2020 (Actual)
- Primary completion
- Jun 5, 2024 (Actual)
- Completion
- Jul 12, 2024 (Actual)
- Last update posted
- Jun 5, 2026
2020 – 2024
United States locations
- U.S. sites
- 88
- U.S. states
- 29
- U.S. cities
- 67
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Cardiology, PC | Birmingham | Alabama | 35211 | — |
| Cardiovascular Associates of the Southeast | Birmingham | Alabama | 35243 | — |
| Univ of Alabama Birmingham | Birmingham | Alabama | 35294 | — |
| Chandler Regional Medical Center | Chandler | Arizona | 85224 | — |
| Abrazo Diabetes Care Center | Glendale | Arizona | 85308 | — |
| Central Arkansas Veteran's Healthcare System | Little Rock | Arkansas | 72205 | — |
| Cardio Innovation & Resch Ctr | Long Beach | California | 90813 | — |
| Angel City Research, Inc. | Los Angeles | California | 90010 | — |
| St. Joseph Heritage Healthcare_Mission Viejo | Mission Viejo | California | 92691 | — |
| Adventist Hlth St Helena Hosp | St. Helena | California | 94574 | — |
| Stanford University Medical Center | Stanford | California | 94305 | — |
| Stanford University_Stanford | Stanford | California | 94305 | — |
| Rocky Mount Reg VA Med-DN | Aurora | Colorado | 80045 | — |
| UC Health Heart & Vascular Center | Aurora | Colorado | 80045 | — |
| Univ of Colorado at Denver | Aurora | Colorado | 80045 | — |
| Bay Area Cardiology Associates, P.A. | Brandon | Florida | 33511 | — |
| Clearwater Cardiovascular Consultants | Clearwater | Florida | 33756 | — |
| Tampa Bay Medical Research | Clearwater | Florida | 33761 | — |
| Jacksonville Ctr For Clin Res | Jacksonville | Florida | 32216 | — |
| CV Res Ctr of S Florida | Miami | Florida | 33173 | — |
| Cardiovascular Institute of Central Florida | Ocala | Florida | 34471 | — |
| DMI Research | Pinellas Park | Florida | 33782 | — |
| Cardiovascular Ctr of Sarasota | Sarasota | Florida | 34239 | — |
| University of South Florida | Tampa | Florida | 33606 | — |
| Piedmont Heart Institute | Atlanta | Georgia | 30309 | — |
| Accel Research Site-Georgia | Eatonton | Georgia | 31024 | — |
| Reg Infectious Dis Infuse Ctr | La Grange | Georgia | 30240 | — |
| Aiyan Diabetes Center | Martinez | Georgia | 30907 | — |
| Atlanta Heart Specialists, LLC | Tucker | Georgia | 30084 | — |
| Northwestern University_Chicago | Chicago | Illinois | 60611 | — |
| Endeavor Health Glenbook Hosp | Glenview | Illinois | 60026 | — |
| Central IL Diabetes and Clinical Research | Springfield | Illinois | 62701 | — |
| Cardiovascular Rsrch of NW_IN | Munster | Indiana | 46321 | — |
| Central Cardio Assoc HPS | Elizabethtown | Kentucky | 42701 | — |
| Cambridge Medical Trials | Alexandria | Louisiana | 71301 | — |
| LOUISIANA HEART Center | Covington | Louisiana | 70433 | — |
| Clinical Trials of Ame, LLC | Monroe | Louisiana | 71201 | — |
| Ascension Saint Agnes Heart Ca | Baltimore | Maryland | 21229 | — |
| Boston Medical Center_Boston_1 | Boston | Massachusetts | 02118 | — |
| Boston Medical Center_Cary | Boston | Massachusetts | 02118 | — |
| Steward St. Elizabeth's Medical Center | Boston | Massachusetts | 02135 | — |
| Minneapolis Cardiology Assoc | Minneapolis | Minnesota | 55407-1195 | — |
| University of Minnesota_Minneapolis_1 | Minneapolis | Minnesota | 55455 | — |
| Amicis Centers of Clinical Research | St Louis | Missouri | 63128 | — |
| Nebraska West Iowa Hlth System | Omaha | Nebraska | 68105 | — |
| Methodist Phys Clin Heart Cons | Omaha | Nebraska | 68114 | — |
| Dartmouth-Hitchcock Med Ctr | Lebanon | New Hampshire | 03766 | — |
| NJ Heart | Linden | New Jersey | 07036 | — |
| NYU Langone Med Assoc Chelsea | New York | New York | 10001 | — |
| Mount Sinai Hosp at NYC | New York | New York | 10029 | — |
| UNC- Chapel Hill | Chapel Hill | North Carolina | 27599 | — |
| NC Heart and Vascular Research | Raleigh | North Carolina | 27607 | — |
| Accellacare_NC | Wilmington | North Carolina | 28401 | — |
| Lillestol Research LLC | Fargo | North Dakota | 58104 | — |
| MetroHealth Medical Center | Cleveland | Ohio | 44109 | — |
| Mount Carmel Heart and Vascular | Columbus | Ohio | 43213 | — |
| Advanced Med Res Maumee | Maumee | Ohio | 43537 | — |
| South Oklahoma Heart Research, LLC | Oklahoma City | Oklahoma | 73135 | — |
| Capital Area Research LLC | Camp Hill | Pennsylvania | 17011 | — |
| Penn Presb Med Ctr | Philadelphia | Pennsylvania | 19104 | — |
| Thomas Jefferson Univ Di Rsrch Ctr | Philadelphia | Pennsylvania | 19107 | — |
| Temple University Hospital | Philadelphia | Pennsylvania | 19140 | — |
| Vanderbilt U Med Ctr_Nashville | Nashville | Tennessee | 37232 | — |
| PharmaTex Research | Amarillo | Texas | 79106 | — |
| St. David's Medical Center | Austin | Texas | 78705 | — |
| Soltero Cardiovascular Research Center | Dallas | Texas | 75226 | — |
| Velocity Clinical Res-Dallas | Dallas | Texas | 75230 | — |
| UT Southwestern Med Cntr | Dallas | Texas | 75390-9302 | — |
| UT Southwestern | Dallas | Texas | 75390 | — |
| Houston Methodist Hospital | Houston | Texas | 77030-2703 | — |
| Northwest Houston Cardiology, P.A. | Houston | Texas | 77070 | — |
| Houston Heart & Vascular Associates | Humble | Texas | 77338 | — |
| Texas Cardiology Associates of Houston | Kingwood | Texas | 77339 | — |
| Texas Tech University Health Science Center | Lubbock | Texas | 79430-8183 | — |
| North Dallas Research Associates | McKinney | Texas | 75069 | — |
| Clinical Trials of Texas, LLC | San Antonio | Texas | 78229 | — |
| Univ Of Texas Hlth Science Cntr | San Antonio | Texas | 78229 | — |
| UT Health San Antonio | San Antonio | Texas | 78229 | — |
| San Antonio Endovascular and Heart Institute | San Antonio | Texas | 78258 | — |
| Cardiovascular Associates East Texas | Tyler | Texas | 75701 | — |
| Victoria Heart and Vasc Ctr | Victoria | Texas | 77901 | — |
| Alpine Research Organization Inc | Farmington | Utah | 84025 | — |
| Inova Heart and Vascular Institute | Falls Church | Virginia | 22042-3300 | — |
| Carient Heart and Vascular | Manassas | Virginia | 20109 | — |
| Roanoke Heart Institute | Roanoke | Virginia | 24014 | — |
| Selma Medical Associates | Winchester | Virginia | 22601-3834 | — |
| Winchester Medical Center | Winchester | Virginia | 22601 | — |
| Aspirus Research Institute | Wausau | Wisconsin | 54401 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 195 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT04560998, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Jun 5, 2026 · Synced Nov 9, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT04560998 live on ClinicalTrials.gov.