HORIZON: A Phase II Study to Evaluate the Safety and Efficacy of Two Doses of GT005
Public ClinicalTrials.gov record NCT04566445. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
HORIZON: A Phase II, Open-label, Outcomes-assessor Masked, Multicentre, Randomised, Controlled Study to Evaluate the Safety and Efficacy of Two Doses of GT005 Administered as a Single Subretinal Injection in Subjects With Geographic Atrophy Secondary to Dry Age-related Macular Degeneration
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
The purpose of this clinical study was to evaluate the safety and efficacy of two doses of GT005 administered as a single subretinal injection in subjects with geographic atrophy secondary to age-related macular degeneration (AMD).
Study identification
- NCT ID
- NCT04566445
- Recruitment status
- Terminated
- Study type
- Interventional
- Phase
- Phase 2
- Enrollment
- 255 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 55 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Sep 28, 2020 (Actual)
- Primary completion
- Jun 10, 2024 (Actual)
- Completion
- Jun 10, 2024 (Actual)
- Last update posted
- Jan 28, 2026
2020 – 2024
United States locations
- U.S. sites
- 45
- U.S. states
- 23
- U.S. cities
- 44
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Retinal Research Institute (retina consultants of AZ) | Phoenix | Arizona | 85053 | — |
| Retina Vitreous Associates Medical Group | Beverly Hills | California | 90211 | — |
| Retina Consultants of Orange County | Fullerton | California | 92835 | — |
| Northern California Retina Vitreous Associates | Mountain View | California | 94040 | — |
| Byers Eye Institute at Stanford | Palo Alto | California | 94303 | — |
| Retina Consultants of San Diego | Poway | California | 92064 | — |
| University of California (UC) Davis Medical Group Eye Center | Sacramento | California | 95817 | — |
| Southwest Retina Research Center | Durango | Colorado | 81303 | — |
| Rand Eye Institute | Deerfield Beach | Florida | 33064 | — |
| VitreoRetinal Associates, P.A. | Gainesville | Florida | 32607 | — |
| Bascom Palmer Eye Institute | Miami | Florida | 33136 | — |
| Retina Vitreous Associates of Florida | St. Petersburg | Florida | 33711 | — |
| Southeast Retina Center | Augusta | Georgia | 30909 | — |
| Georgia Retina PC | Marietta | Georgia | 30060 | — |
| Illinois Retina Associates | Chicago | Illinois | 60657 | — |
| University Retina Macula Associates PC | Lemont | Illinois | 60452 | — |
| Midwest Eye Institute Northside | Indianapolis | Indiana | 46290 | — |
| Wolfe Eye Clinic | West Des Moines | Iowa | 50266 | — |
| Retina Associates, LLC | Shawnee Mission | Kansas | 66204 | — |
| The Retina Care Center | Baltimore | Maryland | 21209 | — |
| Ophthalamic Consultants of Boston (OCB) | Boston | Massachusetts | 02114 | — |
| Retina Associates of Michigan | Grand Blanc | Michigan | 48439 | — |
| Associated Retinal Consultants PC | Royal Oak | Michigan | 48073 | — |
| Sierra Eye Associates | Reno | Nevada | 89502 | — |
| Columbia University Medical Center | New York | New York | 10032 | — |
| Retina Associates of Western New York | Rochester | New York | 14620 | — |
| Duke Eye Center | Durham | North Carolina | 27705 | — |
| Cincinnati Eye Institute | Cincinnati | Ohio | 45242 | — |
| Cleveland Clinic | Cleveland | Ohio | 44195 | — |
| Oregon Retina | Eugene | Oregon | 97401 | — |
| Casey Eye Institute - OHSU | Portland | Oregon | 97239 | — |
| Erie Retinal Surgery ,INC | Erie | Pennsylvania | 16507 | — |
| Mid Atlantic Retina - Wills Eye Hospital | Philadelphia | Pennsylvania | 19107 | — |
| Palmetto Retina Center | West Columbia | South Carolina | 29169 | — |
| Charles Retina Institute | Germantown | Tennessee | 38138 | — |
| Southeastern Retina Associates, PC | Knoxville | Tennessee | 37922 | — |
| Austin Research Center for Retina, PLLC | Austin | Texas | 78705 | — |
| Retina Consultants of Houston-TMC | Bellaire | Texas | 77401 | — |
| Retina Foundation of the Southwest | Dallas | Texas | 75231 | — |
| Texas Retina Associates (Dallas) | Dallas | Texas | 75231 | — |
| Retinal Consultants of San Antonio | San Antonio | Texas | 78240 | — |
| Retina Consultants of Houston | The Woodlands | Texas | 77384 | — |
| Rocky Mountain Retina Consultants | Salt Lake City | Utah | 84107 | — |
| Department of Ophthalmology UW Medicine | Seattle | Washington | 98104-2499 | — |
| Retina Center Northwest | Silverdale | Washington | 98383 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 17 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT04566445, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Jan 28, 2026 · Synced Oct 18, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT04566445 live on ClinicalTrials.gov.