A Study of Olezarsen (Formerly Known as AKCEA-APOCIII-LRx) Administered to Patients With Familial Chylomicronemia Syndrome (FCS)
Public ClinicalTrials.gov record NCT04568434. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Randomized, Double-Blind, Placebo-Controlled, Phase 3 Study of AKCEA-APOCIII-LRx Administered Subcutaneously to Patients With Familial Chylomicronemia Syndrome (FCS)
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
The purpose of the study was to evaluate the efficacy of olezarsen as compared to placebo on the percent change in fasting triglycerides (TG) from baseline.
Study identification
- NCT ID
- NCT04568434
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 66 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Nov 18, 2020 (Actual)
- Primary completion
- Jul 14, 2023 (Actual)
- Completion
- Oct 17, 2023 (Actual)
- Last update posted
- Mar 6, 2025
2020 – 2023
United States locations
- U.S. sites
- 17
- U.S. states
- 13
- U.S. cities
- 16
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Diabetes/Lipid Management & Research Center | Huntington Beach | California | 92648 | — |
| University of California, San Francisco (UCSF) - Medical Center | San Francisco | California | 94143 | — |
| Excel Medical Clinical Trials, LLC | Boca Raton | Florida | 33434 | — |
| NorthShore University Health System | Evanston | Illinois | 60201 | — |
| Advocate Health and Hospitals Corporation - Lutheran General Hospital | Park Ridge | Illinois | 60068 | — |
| Ascension St. Vincent Cardiovascular Research Institute | Indianapolis | Indiana | 46290 | — |
| University of Kansas Medical Center (KUMC) | Kansas City | Kansas | 66160 | — |
| University of Michigan- Endocrinology & Metabolism | Ann Arbor | Michigan | 48105 | — |
| New York University (NYU) Langone Medical Center | New York | New York | 10016 | — |
| Columbia University Medical Center | New York | New York | 10032 | — |
| Moses H. Cone Memorial Hospital | Greensboro | North Carolina | 27401 | — |
| University of Pennsylvania | Philadelphia | Pennsylvania | 19104 | — |
| Vanderbilt University | Nashville | Tennessee | 37232 | — |
| University of Texas Southwestern | Dallas | Texas | 75390 | — |
| Baylor College of Medicine | Houston | Texas | 77030 | — |
| York Clinical Research LLC | Norfolk | Virginia | 23510 | — |
| West Virginia University Heart and Vascular Institute | Morgantown | West Virginia | 26506 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 30 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT04568434, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Mar 6, 2025 · Synced Oct 21, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT04568434 live on ClinicalTrials.gov.