Efficacy and Safety of Molnupiravir (MK-4482) in Non-Hospitalized Adult Participants With COVID-19 (MK-4482-002)
Public ClinicalTrials.gov record NCT04575597. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase 2/3, Randomized, Placebo-Controlled, Double-Blind Clinical Study to Evaluate the Efficacy, Safety, and Pharmacokinetics of MK-4482 in Non-Hospitalized Adults With COVID-19.
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
This study aims to evaluate the safety, tolerability and efficacy of molnupiravir (MK-4482) compared to placebo. The primary hypothesis is that molnupiravir is superior to placebo as assessed by the percentage of participants who are hospitalized and/or die through Day 29
Study identification
- NCT ID
- NCT04575597
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 2, Phase 3
- Enrollment
- 1,735 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Oct 18, 2020
- Primary completion
- May 4, 2022
- Completion
- May 4, 2022
- Last update posted
- Jun 27, 2023
2020 – 2022
United States locations
- U.S. sites
- 32
- U.S. states
- 15
- U.S. cities
- 30
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Phoenix Medical Group ( Site 1822) | Peoria | Arizona | 85381 | — |
| Ruane Clinical Research Group, Inc. ( Site 2406) | Los Angeles | California | 90036 | — |
| Men's Health Foundation ( Site 1820) | Los Angeles | California | 90069 | — |
| Carbon Health Technologies Inc ( Site 2505) | North Hollywood | California | 91606 | — |
| UC Davis Medical Center ( Site 1833) | Sacramento | California | 95817 | — |
| Emerson Clinical Research Institute ( Site 1828) | Washington D.C. | District of Columbia | 20011 | — |
| JEM Research Institute ( Site 2508) | Atlantis | Florida | 33462 | — |
| Midway Immunology and Research Center ( Site 1837) | Ft. Pierce | Florida | 34982 | — |
| Indago Research & Health Center, Inc ( Site 1809) | Hialeah | Florida | 33012 | — |
| Advanced Research For Health Improvement LLC ( Site 1816) | Immokalee | Florida | 34142 | — |
| Advanced Medical Research, LLC ( Site 1864) | Miami | Florida | 33174 | — |
| Advanced Research For Health Improvement LLC ( Site 1813) | Naples | Florida | 34102 | — |
| Bliss Healthcare Services ( Site 1847) | Orlando | Florida | 32806 | — |
| Javara Inc. ( Site 1869) | Albany | Georgia | 31707 | — |
| IACT Health ( Site 1818) | Columbus | Georgia | 31904 | — |
| Javara Inc. ( Site 1868) | Fayetteville | Georgia | 30214 | — |
| Loretto Hospital ( Site 1886) | Chicago | Illinois | 60644 | — |
| Jadestone Clinical Research, LLC ( Site 2502) | Laurel | Maryland | 20708 | — |
| Michigan Center of Medical Research ( Site 2500) | Farmington Hills | Michigan | 48334 | — |
| University of Nebraska Medical Center ( Site 2414) | Omaha | Nebraska | 68198 | — |
| Amici Clinical Research LLC ( Site 2507) | Raritan | New Jersey | 08869 | — |
| University of New Mexico, Health Sciences Center ( Site 1819) | Albuquerque | New Mexico | 87131 | — |
| AXCES Research Group ( Site 2418) | Santa Fe | New Mexico | 87505 | — |
| Saint Hope Foundation, Inc. ( Site 1830) | Bellaire | Texas | 77401 | — |
| The Crofoot Research Center, Inc. ( Site 1812) | Houston | Texas | 77098 | — |
| Javara Inc. ( Site 1866) | Sugar Land | Texas | 77478 | — |
| Clinical Research Partners, LLC. ( Site 2503) | Richmond | Virginia | 23226 | — |
| Swedish Medical Center First Hill ( Site 1807) | Seattle | Washington | 98104 | — |
| Fred Hutchinson Cancer Center ( Site 1829) | Seattle | Washington | 98109 | — |
| Multicare Health System ( Site 1811) | Spokane | Washington | 99204 | — |
| Multicare Health System ( Site 1814) | University Place | Washington | 98466 | — |
| Medical College Of Wisconsin ( Site 2510) | Milwaukee | Wisconsin | 53226 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 141 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT04575597, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Jun 27, 2023 · Synced Sep 3, 2026
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Open the official record
The complete protocol, eligibility criteria, and contact information for NCT04575597 live on ClinicalTrials.gov.