A Study of Sotatercept for the Treatment of Pulmonary Arterial Hypertension (MK-7962-003/A011-11)(STELLAR)
Public ClinicalTrials.gov record NCT04576988. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase 3, Randomized, Double-Blind, Placebo-Controlled Study to Compare the Efficacy and Safety of Sotatercept Versus Placebo When Added to Background Pulmonary Arterial Hypertension (PAH) Therapy for the Treatment of PAH
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
The objectives of this study are to evaluate the efficacy and safety of sotatercept (MK-7962) treatment (plus background pulmonary arterial hypertension (PAH) therapy) versus placebo (plus background PAH therapy) at 24 weeks in adults with PAH. The primary hypothesis of the study is that the participants receiving sotatercept will have improved 6-minute walk distance (6MWD) at 24 weeks compared to participants receiving placebo.
Study identification
- NCT ID
- NCT04576988
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 3
- Lead sponsor
- Acceleron Pharma, Inc., a wholly-owned subsidiary of Merck & Co., Inc., Rahway, NJ USA
- Industry
- Enrollment
- 324 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Jan 25, 2021 (Actual)
- Primary completion
- Aug 26, 2022 (Actual)
- Completion
- Dec 6, 2022 (Actual)
- Last update posted
- Sep 19, 2024
2021 – 2022
United States locations
- U.S. sites
- 39
- U.S. states
- 24
- U.S. cities
- 35
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Arizona Pulmonary Specialists (Site 1010) | Phoenix | Arizona | 85012 | — |
| Pulmonary Associates, PA (Site 1008) | Phoenix | Arizona | 85032 | — |
| University of Arizona (Site 1006) | Tucson | Arizona | 85724 | — |
| University of California San Diego Medical Center (Site 1002) | San Diego | California | 92037 | — |
| University of California - Davis Medical Center (Site 1064) | Sherman Oaks | California | 95817 | — |
| Stanford University Medical Center (Site 1024) | Stanford | California | 94305 | — |
| Harbor UCLA Medical Center (Site 1028) | Torrance | California | 90502 | — |
| University of Colorado Hospital (Site 1013) | Aurora | Colorado | 80045 | — |
| The George Washington University Medical Faculty Associates (Site 1025) | Washington D.C. | District of Columbia | 20037 | — |
| Mayo Clinic Jacksonville (Site 1045) | Jacksonville | Florida | 32256 | — |
| University of South Florida (Site 1043) | Tampa | Florida | 33606 | — |
| The Emory Clinic (Site 1030) | Atlanta | Georgia | 30322 | — |
| Norton Pulmonary Specialists (Site 1066) | Louisville | Kentucky | 40202 | — |
| Tufts Medical Center - PPDS (Site 1012) | Boston | Massachusetts | 02111 | — |
| Brigham and Women's Hospital (Site 1014) | Boston | Massachusetts | 02115 | — |
| University of Michigan (Site 1011) | Ann Arbor | Michigan | 48109-5936 | — |
| University of Minnesota (Site 1062) | Minneapolis | Minnesota | 55455 | — |
| Mayo Clinic (Site 1023) | Rochester | Minnesota | 55905 | — |
| University of Kansas Medical Center (Site 1020) | Kansas City | Missouri | 66160-7232 | — |
| Washington University School of Medicine (Site 1022) | St Louis | Missouri | 63110 | — |
| Nebraska Medical Center (Site 1053) | Omaha | Nebraska | 68105 | — |
| Renown Institute for Heart & Vascular Health (Site 1055) | Reno | Nevada | 89502-1262 | — |
| New York Presbyterian Hospital (Site 1046) | New York | New York | 10032 | — |
| Duke University Medical Center (Site 1026) | Durham | North Carolina | 27710 | — |
| University of Cincinnati Medical Center (Site 1035) | Cincinnati | Ohio | 45219-2316 | — |
| The Carl and Edyth Lindner Center for Research and Education at the Christ Hospital (Site 1001) | Cincinnati | Ohio | 45219 | — |
| University Hospitals Cleveland Medical Center (Site 1005) | Cleveland | Ohio | 44106 | — |
| The Ohio State University Wexner Medical Center (Site 1032) | Columbus | Ohio | 43210 | — |
| Oregon Health and Science University (Site 1054) | Portland | Oregon | 97232 | — |
| University of Pennsylvania (Site 1047) | Philadelphia | Pennsylvania | 19104 | — |
| UPMC Presbyterian. UPMC Presbyterian Hospital (Site 1059) | Pittsburgh | Pennsylvania | 15213 | — |
| Rhode Island Hospital (Site 1033) | Providence | Rhode Island | 02903 | — |
| Medical University of South Carolina - PPDS (Site 1003) | Charleston | South Carolina | 29425-8900 | — |
| Statcare Pulmonary Consultants - Knoxville (Site 1031) | Knoxville | Tennessee | 37919 | — |
| Vanderbilt University Medical Center (Site 1027) | Nashville | Tennessee | 37232 | — |
| CHI St. Luke's Health Baylor College of Medicine Medical Center (Site 1044) | Houston | Texas | 77030 | — |
| Houston Methodist Hospital (Site 1009) | Houston | Texas | 77030 | — |
| University of Utah - PPDS (Site 1049) | Salt Lake City | Utah | 84132 | — |
| University of Washington Medical Center - Montlake (Site 1067) | Seattle | Washington | 98195-0001 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 81 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT04576988, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Sep 19, 2024 · Synced Oct 22, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT04576988 live on ClinicalTrials.gov.