Study of Efficacy and Safety of LNP023 in Primary IgA Nephropathy Patients
Public ClinicalTrials.gov record NCT04578834. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Multi-center, Randomized, Double-blind, Placebo-controlled, Parallel Group, Phase III Study to Evaluate the Efficacy and Safety of LNP023 in Primary IgA Nephropathy Patients
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
The study is designed as a multicenter, randomized, double-blind, placebo controlled study to demonstrate the superiority of iptacopan (LNP023) at a dose of 200 mg b.i.d. compared to placebo on top of maximally tolerated ACEi or ARB on reduction of proteinuria and slowing renal disease progression in primary IgA Nephropathy patients.
Study identification
- NCT ID
- NCT04578834
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 518 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years to 100 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Jan 25, 2021 (Actual)
- Primary completion
- Sep 19, 2025 (Actual)
- Completion
- Sep 19, 2025 (Actual)
- Last update posted
- Dec 23, 2025
2021 – 2025
United States locations
- U.S. sites
- 22
- U.S. states
- 17
- U.S. cities
- 22
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| AZ Kidney Dise and Hypertension Ctr | Glendale | Arizona | 85306 | — |
| AKDHC Medical Research ServicesLLC | Phoenix | Arizona | 85016 | — |
| UCLA Medical Center | Los Angeles | California | 90095 | — |
| Kaiser Permanente | San Diego | California | 92111 | — |
| North America Research Institute | San Dimas | California | 91773 | — |
| University of Colorado Anschutz | Aurora | Colorado | 80045 | — |
| Nephrology Associates PA | Newark | Delaware | 19713 | — |
| Boise Kidney and Hypertension | Boise | Idaho | 83706 | — |
| CaRe Research | Chubbuck | Idaho | 83202 | — |
| Nep Assoc of Northern Illinois | Hinsdale | Illinois | 60521 | — |
| Renal Associates of Baton Rouge | Baton Rouge | Louisiana | 80808 | — |
| Johns Hopkins Hospital | Baltimore | Maryland | 21287 | — |
| Brigham and Womens Hosp Harvard Med School | Boston | Massachusetts | 02115 | — |
| University of Michigan | Ann Arbor | Michigan | 48109 | — |
| Mayo Clinic Rochester | Rochester | Minnesota | 55905 | — |
| Clin Rsrch Consult a JCCT Company | Kansas City | Missouri | 64111 | — |
| DaVita Clinical Research | Las Vegas | Nevada | 89146 | — |
| New Jersey Kidney Care | Jersey City | New Jersey | 07305 | — |
| Columbia University Irving Medical | New York | New York | 10032 | — |
| Dallas Renal Group | Dallas | Texas | 75230 | — |
| Prolato Clinical Research Center | Houston | Texas | 77054 | — |
| Univ of Washington Medi Cen | Seattle | Washington | 98104 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 155 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT04578834, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Dec 23, 2025 · Synced Oct 21, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT04578834 live on ClinicalTrials.gov.