A Study of MK-3655 in Individuals With Pre-cirrhotic Nonalcoholic Steatohepatitis (NASH) (MK-3655-001)
Public ClinicalTrials.gov record NCT04583423. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase 2b Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Efficacy and Safety of MK-3655 in Individuals With Pre-cirrhotic Nonalcoholic Steatohepatitis.
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
This study will evaluate the effect of each dose of MK-3655 versus placebo on the percentage of individuals with NASH resolution without worsening of fibrosis after 52 weeks. The primary hypothesis of the study is that at least 1 dose of MK-3655 is superior to placebo with respect to the percentage of individuals with NASH resolution without worsening of fibrosis after 52 weeks.
Study identification
- NCT ID
- NCT04583423
- Recruitment status
- Terminated
- Study type
- Interventional
- Phase
- Phase 2
- Enrollment
- 183 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years to 80 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Nov 11, 2020 (Actual)
- Primary completion
- Apr 13, 2023 (Actual)
- Completion
- Apr 13, 2023 (Actual)
- Last update posted
- Jul 17, 2025
2020 – 2023
United States locations
- U.S. sites
- 48
- U.S. states
- 16
- U.S. cities
- 40
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Adobe Clinical Research, LLC ( Site 2644) | Tucson | Arizona | 85712 | — |
| Arizona Liver Health ( Site 9026) | Tucson | Arizona | 85712 | — |
| Del Sol Research Management ( Site 2674) | Tucson | Arizona | 85715 | — |
| Arkansas Gastroenterology - North Little Rock ( Site 9015) | North Little Rock | Arkansas | 72117 | — |
| Hope Clinical Research, Inc. ( Site 2601) | Canoga Park | California | 91303 | — |
| Velocity Clinical Research, Huntington Park ( Site 9022) | Huntington Park | California | 90255 | — |
| UCSD - Altman Clinical and Translational Research Institute -UC San Diego NAFLD Research Center ( Si | La Jolla | California | 92037 | — |
| Ruane Clinical Research Group, Inc ( Site 9014) | Los Angeles | California | 90036 | — |
| Velocity Clinical Research, Westlake ( Site 9013) | Los Angeles | California | 90057 | — |
| Catalina Research Institute, LLC ( Site 2643) | Montclair | California | 91763 | — |
| Velocity Clinical Research, Panorama City ( Site 9001) | Panorama City | California | 91402 | — |
| California Liver Research Institute ( Site 9025) | Pasadena | California | 91105 | — |
| Quest Clinical Research ( Site 9011) | San Francisco | California | 94115 | — |
| Velocity Clinical Research, Santa Ana ( Site 9002) | Santa Ana | California | 92704 | — |
| Peak Gastroenterology Associates ( Site 2645) | Colorado Springs | Colorado | 80920 | — |
| Top Medical Research, Inc ( Site 2673) | Cutler Bay | Florida | 33189 | — |
| Covenant Metabolic Specialists, LLC ( Site 9027) | Fort Myers | Florida | 33912 | — |
| North Florida South Georgia Veterans Health System ( Site 2613) | Gainesville | Florida | 32608 | — |
| Indago Research and Health Center Inc ( Site 2610) | Hialeah | Florida | 33012 | — |
| Sweet Hope Research Specialty Inc ( Site 2660) | Hialeah | Florida | 33016 | — |
| Genoma Research Group, Inc. ( Site 2669) | Miami | Florida | 33173 | — |
| Floridian Clinical Research, LLC ( Site 2656) | Miami Lakes | Florida | 33016-1518 | — |
| Ocean Blue Medical Research Center Inc ( Site 2667) | Miami Springs | Florida | 33166 | — |
| Sensible Healthcare Llc ( Site 2607) | Ocoee | Florida | 34761 | — |
| Synexus Research ( Site 2672) | Orlando | Florida | 32806 | — |
| Southeast Clinical Research Center ( Site 9003) | Dalton | Georgia | 30720 | — |
| The University of Iowa ( Site 2655) | Iowa City | Iowa | 52242 | — |
| Legacy Clinical Solutions: Tandem Clinical Research, LLC ( Site 2650) | Marrero | Louisiana | 70072 | — |
| The National Diabetes & Obesity Research Institute ( Site 9017) | Biloxi | Mississippi | 39532 | — |
| Kansas City Research Institute ( Site 9018) | Kansas City | Missouri | 64131 | — |
| Excel Clinical Research, LLC ( Site 2603) | Las Vegas | Nevada | 89109 | — |
| Velocity Clinical Research, Syracuse ( Site 9016) | East Syracuse | New York | 13057 | — |
| NYU Langone Health, New York ( Site 2627) | New York | New York | 10016 | — |
| Hillmont G.I. ( Site 9019) | Flourtown | Pennsylvania | 19031 | — |
| Regional Gastroenterology Associates of Lancaster, LTD ( Site 9020) | Lancaster | Pennsylvania | 17601 | — |
| Regional Gastroenterology Associates of Lancaster, LTD ( Site 9004) | Wyomissing | Pennsylvania | 19610 | — |
| Premier Medical Group ( Site 9010) | Clarksville | Tennessee | 37040 | — |
| Texas Clinical Research Institute ( Site 2619) | Arlington | Texas | 76012 | — |
| The Liver Institute at Methodist Dallas Medical Center ( Site 2638) | Dallas | Texas | 75203 | — |
| DHR Health Institute for Research and Development ( Site 9006) | Edinburg | Texas | 78539 | — |
| South Texas Research Institute ( Site 9012) | Edinburg | Texas | 78539 | — |
| Baylor College of Medicine - Advanced Liver Therapies ( Site 2670) | Houston | Texas | 77030 | — |
| The Crofoot Research Center, Inc. ( Site 2611) | Houston | Texas | 77098 | — |
| Quality Research ( Site 9024) | San Antonio | Texas | 78209 | — |
| American Research Corporation at Texas Liver Institute ( Site 2634) | San Antonio | Texas | 78215 | — |
| Clinical Trials of Texas, LLC ( Site 2614) | San Antonio | Texas | 78229 | — |
| Impact Research Institute ( Site 2685) | Waco | Texas | 76710 | — |
| Virginia Commonwealth University Health System ( Site 2657) | Richmond | Virginia | 23298 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 132 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT04583423, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Jul 17, 2025 · Synced Oct 21, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT04583423 live on ClinicalTrials.gov.