A Study to Evaluate the Efficacy, Durability, and Safety of KSI-301 Compared to Aflibercept in Patients With Macular Edema Due to Retinal Vein Occlusion (RVO)
Public ClinicalTrials.gov record NCT04592419. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Prospective, Randomized, Double-masked, Active Comparator-controlled, Multi-center, Two-arm, Phase 3 Study to Evaluate the Efficacy and Safety of Intravitreal KSI-301 Compared With Intravitreal Aflibercept in Participants With Visual Impairment Due to Treatment-naïve Macular Edema Secondary to Retinal Vein Occlusion (RVO)
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
This Phase 3 study will evaluate the efficacy, durability, and safety of KSI-301 compared to aflibercept, in participants with macular edema due to treatment-naïve branch (BRVO) or central retinal vein occlusion (CRVO).
Study identification
- NCT ID
- NCT04592419
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 568 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Sep 25, 2020 (Actual)
- Primary completion
- Jun 10, 2022 (Actual)
- Completion
- Jan 19, 2023 (Actual)
- Last update posted
- Jun 26, 2024
2020 – 2023
United States locations
- U.S. sites
- 81
- U.S. states
- 28
- U.S. cities
- 78
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Northwest Arkansas Retina Associates | Phoenix | Arizona | 85014 | — |
| Retinal Research Institute, LLC | Phoenix | Arizona | 85014 | — |
| Retina Vitreous Associates | Beverly Hills | California | 90211 | — |
| Eye Medical Center of Fresno | Fresno | California | 93720 | — |
| Retina Consultants of Orange County | Fullerton | California | 92835 | — |
| UCSD Jacobs Retina Center | La Jolla | California | 92037 | — |
| Northern California Retina Vitreous Associates | Mountain View | California | 94040 | — |
| Retina Consultants of San Diego | Poway | California | 92064 | — |
| Retina Consultants of Southern California | Redlands | California | 92374 | — |
| Retinal Consultants Medical Group Inc | Sacramento | California | 95819 | — |
| Orange County Retina Medical Group | Santa Ana | California | 92705 | — |
| California Retina Consultants | Santa Maria | California | 93454 | — |
| Colorado Retina Associates PC | Lakewood | Colorado | 80228 | — |
| Conneticut Eye Consultants | Danbury | Connecticut | 06810 | — |
| Retina Group of New England | Waterford | Connecticut | 06385 | — |
| Florida Eye Clinic | Altamonte Springs | Florida | 32701 | — |
| Retina Group of Florida | Boca Raton | Florida | 33431 | — |
| Florida Eye Microsurgical Institute | Boynton Beach | Florida | 33426 | — |
| The Macula Center/ Blue Ocean Clinical Research | Clearwater | Florida | 33761 | — |
| Rand Eye Institute | Deerfield Beach | Florida | 33064 | — |
| National Ophthalmic Research Institute | Fort Myers | Florida | 33912 | — |
| Vitreo Retinal Associates | Gainesville | Florida | 32607 | — |
| Florida Eye Associates | Melbourne | Florida | 32901 | — |
| Florida Retina Institute | Orlando | Florida | 32806 | — |
| Retina Specialty Institute | Pensacola | Florida | 32503 | — |
| Fort Lauderdale Eye Institute | Plantation | Florida | 33324 | — |
| Southern Vitreoretinal Associates | Tallahassee | Florida | 32308 | — |
| Retina Associates of Florida | Tampa | Florida | 33609 | — |
| Center for Retina & Macular Disease | Winter Haven | Florida | 33880 | — |
| Southeast Retina Center | Augusta | Georgia | 30909 | — |
| Springfield Clinic LLP | Springfield | Illinois | 62703 | — |
| Talley Eye | Evansville | Indiana | 47710 | — |
| Wolfe Eye Clinic | West Des Moines | Iowa | 50266 | — |
| Retina Associates PA | Lenexa | Kansas | 66215 | — |
| Vitreo Retinal Consultants and Surgeons | Wichita | Kansas | 67214 | — |
| Retina Associates of Kentucky | Lexington | Kentucky | 40509 | — |
| Maine Eye Center | Portland | Maine | 04102 | — |
| Retina Group of Washington | Chevy Chase | Maryland | 20815 | — |
| Cumberland Valley Retina Consultants PC | Hagerstown | Maryland | 21740 | — |
| Ophthalmic Consultants of Boston | Boston | Massachusetts | 02114 | — |
| Vitreo Retinal Associates PC | Worcester | Massachusetts | 01603 | — |
| Foundation for Vision Research | Grand Rapids | Michigan | 49525 | — |
| Associated Retinal Consultants PC | Royal Oak | Michigan | 78073 | — |
| Vitreoretinal Surgery PA | Edina | Minnesota | 55435 | — |
| Retina Consultants of NV | Henderson | Nevada | 89052 | — |
| Sierra Eye Associates | Reno | Nevada | 89502 | — |
| The Retina Center of New Jersey | Bloomfield | New Jersey | 07017 | — |
| NJ Retina | Teaneck | New Jersey | 07605 | — |
| Vitreo Retinal Consultants | Hauppauge | New York | 11788 | — |
| Retina-Vitreous Surgeons of Central NY | Liverpool | New York | 13088 | — |
| Ocli Vision | Oceanside | New York | 11572 | — |
| Retina Associates of Western NY | Rochester | New York | 14620 | — |
| Asheville Eye Associates | Asheville | North Carolina | 28803 | — |
| Charlotte Eye Ear Nose & Throat Associates, P.A. | Charlotte | North Carolina | 28210 | — |
| Retina Associates of Cleveland | Beachwood | Ohio | 44122 | — |
| Retina Associates of Cleveland | Cleveland | Ohio | 44130 | — |
| Retina Northwest | Portland | Oregon | 97210 | — |
| Retina Consultants, LLC | Salem | Oregon | 97302 | — |
| Cascade Medical Research Institute | Springfield | Oregon | 97477 | — |
| Retina Research of Beaufort | Beaufort | South Carolina | 29902 | — |
| Retina Consultants of Carolina | Greenville | South Carolina | 29605 | — |
| Charleston Neuroscience Institute | Ladson | South Carolina | 29456 | — |
| Pametto Retina Center | West Columbia | South Carolina | 29501 | — |
| Black Hills Regional Eye Institute | Rapid City | South Dakota | 57701 | — |
| Charles Retina Institute | Germantown | Tennessee | 38138 | — |
| Southeastern Retina Associates PC | Knoxville | Tennessee | 37909 | — |
| Tennessee Retina PC | Nashville | Tennessee | 37203 | — |
| Retina Research Institute of Texas | Abilene | Texas | 79606 | — |
| Austin Research Center for Retina | Austin | Texas | 78705 | — |
| Austin Retina Associates | Austin | Texas | 78705 | — |
| Retina Research Center | Austin | Texas | 78705 | — |
| Retina Consultants of Texas | Houston | Texas | 77030 | — |
| Retina Consultants of Texas - (Katy) | Katy | Texas | 77494 | — |
| Texas Retina Associates | Plano | Texas | 75075 | — |
| Austin Retina Associates (Round Rock) | Round Rock | Texas | 78681 | — |
| Medical Center Ophthalmology Associates | San Antonio | Texas | 78240 | — |
| Retina Consultants of Texas - (Woodlands) | The Woodlands | Texas | 77384 | — |
| Strategic Clinical Research Group, LLC | Willow Park | Texas | 76087 | — |
| Retina Institute of Virginia | Richmond | Virginia | 23235 | — |
| Retina Center Northwest | Silverdale | Washington | 98383 | — |
| Spokane Eye | Spokane | Washington | 99204 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 60 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT04592419, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Jun 26, 2024 · Synced Oct 18, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT04592419 live on ClinicalTrials.gov.