Immune Modulators for Treating COVID-19
Public ClinicalTrials.gov record NCT04593940. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
Randomized Master Protocol for Immune Modulators for Treating COVID-19
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
ACTIV-1 IM is a master protocol designed to evaluate multiple investigational agents for the treatment of moderately or severely ill patients infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The research objectives are to evaluate each agent with respect to speed of recovery, mortality, illness severity, and hospital resource utilization. Each agent will be evaluated as add-on therapy to the standard of care (SoC) in use at the local clinics, including remdesivir (provided). The SoC may change during the course of the study based on other research findings. Comparisons of the agents among themselves is not a research objective. The study population corresponds to moderately and severely ill patients infected with the coronavirus disease 2019 (COVID-19) virus. Recruitment will target patients already hospitalized for treatment of COVID-19 infection as well as patients being treated for COVID-19 infection in Emergency Departments while waiting to be admitted to the hospital. Patients both in and out of the ICU are included in the study population.
Study identification
- NCT ID
- NCT04593940
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 1,971 participants
Conditions and interventions
Conditions
Interventions
- Infliximab Drug
- Abatacept Drug
- Remdesivir Drug
- cenicriviroc (closed to enrollment as of 3-Sep-2021) Drug
Drug
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Oct 15, 2020 (Actual)
- Primary completion
- Jan 30, 2022 (Actual)
- Completion
- Mar 5, 2022 (Actual)
- Last update posted
- Sep 25, 2023
2020 – 2022
United States locations
- U.S. sites
- 67
- U.S. states
- 31
- U.S. cities
- 57
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Banner University Medical Center | Phoenix | Arizona | 85006 | — |
| University of Arkansas Medical Sciences | Little Rock | Arkansas | 72205 | — |
| Scripps Clinical Medical Group | La Jolla | California | 92037 | — |
| UCLA - Ronald Reagan Medical Center | Los Angeles | California | 90095 | — |
| Riverside University | Moreno Valley | California | 92555 | — |
| UC Irvine Medical Center | Orange | California | 92868 | — |
| Stanford University Medical Center | Palo Alto | California | 94303 | — |
| UCLA Medical Center- Santa Monica | Santa Monica | California | 06037 | — |
| Medstar Washington Hospital Center | Washington D.C. | District of Columbia | 20010 | — |
| University of Florida-Jacksonville | Jacksonville | Florida | 32218 | — |
| University of Illinois at Chicago | Chicago | Illinois | 60607 | — |
| Northwestern University | Chicago | Illinois | 60611 | — |
| Loyola University Medical Center | Maywood | Illinois | 60153 | — |
| University of Iowa | Iowa City | Iowa | 52242 | — |
| University of Kansas | Kansas City | Kansas | 66160 | — |
| University of Kentucky | Lexington | Kentucky | 40536 | — |
| Tulane School of Medicine | New Orleans | Louisiana | 70112 | — |
| University Medical Center New Orleans | New Orleans | Louisiana | 70112 | — |
| Ochsner Medical Center | New Orleans | Louisiana | 70121 | — |
| Anne Arundel Medical Center | Annapolis | Maryland | 21401 | — |
| Johns Hopkins Medical Center | Baltimore | Maryland | 21202 | — |
| Tufts Medical Center | Boston | Massachusetts | 02111 | — |
| Brigham and Women's Hospital | Boston | Massachusetts | 02115 | — |
| Boston Medical Center | Boston | Massachusetts | 02118 | — |
| Beth Israel Deaconess Medical Center | Boston | Massachusetts | 02215 | — |
| U Mass Memorial Medical Center | Worcester | Massachusetts | 01655 | — |
| U Mass University Medical Center | Worcester | Massachusetts | 01655 | — |
| MidMichigan Medical Center- Gratiot | Alma | Michigan | 48640 | — |
| MidMichigan Medical Center - Midland | Midland | Michigan | 48670 | — |
| Mayo Clinic | Rochester | Minnesota | 55905 | — |
| University of Mississippi Medical Center | Jackson | Mississippi | 39216 | — |
| University of Missouri Health Care | Columbia | Missouri | 65212 | — |
| Washington University School of Medicine | St Louis | Missouri | 63110 | — |
| Trinitas Hospital | Elizabeth | New Jersey | 07207 | — |
| Hackensack University Medical Center | Hackensack | New Jersey | 07601 | — |
| Rutgers New Jersey Medical School | New Brunswick | New Jersey | 08901 | — |
| NYU Brooklyn | Brooklyn | New York | 11220 | — |
| University at Buffalo | Buffalo | New York | 14203 | — |
| Flushing Hospital Medical Center | Flushing | New York | 11355 | — |
| Jamaica Hospital Medical Center | Jamaica | New York | 11418 | — |
| NYU Long Island | Long Island City | New York | 10016 | — |
| New York University Langone Medical Center | New York | New York | 10016 | — |
| Harlem Hospital Center | New York | New York | 10037 | — |
| Weill Cornell Medicine | New York | New York | 10065 | — |
| St Lawrence Health System | Potsdam | New York | 13676 | — |
| University of Rochester Medical Center-Strong Memorial Hospital | Rochester | New York | 14642 | — |
| University of North Carolina - Chapel Hill | Chapel Hill | North Carolina | 27599 | — |
| Duke University | Durham | North Carolina | 27710 | — |
| Wake Forest University | Winston-Salem | North Carolina | 27157 | — |
| Mercy Saint Vincent Medical Center | Toledo | Ohio | 43608 | — |
| University of Oklahoma Health Sciences Center | Oklahoma City | Oklahoma | 73104 | — |
| Oregon Health and Science University | Portland | Oregon | 97239 | — |
| Temple University Hospital | Philadelphia | Pennsylvania | 19140 | — |
| Reading Hospital Study | Wyomissing | Pennsylvania | 19610 | — |
| Avera McKennan Hospital | Sioux Falls | South Dakota | 57105 | — |
| University of Tennessee Medical Center | Knoxville | Tennessee | 37920 | — |
| Methodist Health System Clinical Research Institute | Dallas | Texas | 75203 | — |
| University of Texas Health Science Center - Houston | Houston | Texas | 77030 | — |
| University of Texas Health Science Center at San Antonio | San Antonio | Texas | 78229 | — |
| Trinity Mother Frances Hospital | Tyler | Texas | 75701 | — |
| University of Texas Health Center at Tyler | Tyler | Texas | 75708 | — |
| University of Utah | Salt Lake City | Utah | 84108 | — |
| Virginia Commonwealth University Medical Center | Richmond | Virginia | 23298 | — |
| University of Washington Medical Center | Seattle | Washington | 98195 | — |
| Providence Medical Research Center | Spokane | Washington | 99204 | — |
| West Virginia University | Morgantown | West Virginia | 26505 | — |
| Gundersen Health System | La Crosse | Wisconsin | 54601 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 24 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT04593940, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Sep 25, 2023 · Synced Oct 22, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT04593940 live on ClinicalTrials.gov.