A Study to Assess the Efficacy, Safety, and Tolerability of Brensocatib in Participants With Non-Cystic Fibrosis Bronchiectasis
Public ClinicalTrials.gov record NCT04594369. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase 3, Randomized, Double-Blind, Placebo-Controlled Study to Assess the Efficacy, Safety, and Tolerability of Brensocatib Administered Once Daily for 52 Weeks in Subjects With Non-Cystic Fibrosis Bronchiectasis - The ASPEN Study
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
The primary objective of this study is to evaluate the effect of brensocatib at 10 mg and 25 mg compared with placebo on the rate of pulmonary exacerbations (PEs) over the 52-week treatment period.
Study identification
- NCT ID
- NCT04594369
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 1,767 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 12 Years to 85 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Dec 1, 2020 (Actual)
- Primary completion
- Oct 28, 2024 (Actual)
- Completion
- Oct 28, 2024 (Actual)
- Last update posted
- Dec 16, 2025
2020 – 2024
United States locations
- U.S. sites
- 67
- U.S. states
- 29
- U.S. cities
- 64
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| USA013 | Birmingham | Alabama | 35233 | — |
| USA080 | Conway | Arkansas | 72032 | — |
| USA044 | Little Rock | Arkansas | 72205 | — |
| USA104 | Fresno | California | 93702 | — |
| USA055 | Los Angeles | California | 90048 | — |
| USA029 | Newport Beach | California | 92663 | — |
| USA102 | Northridge | California | 91324 | — |
| USA022 | Palm Springs | California | 92262 | — |
| USA024 | Sacramento | California | 95817 | — |
| USA035 | San Diego | California | 92120 | — |
| USA078 | Santa Barbara | California | 93105 | — |
| USA027 | Ventura | California | 93003 | — |
| USA075 | Denver | Colorado | 80206 | — |
| USA017 | Farmington | Connecticut | 06030 | — |
| USA001 | Washington D.C. | District of Columbia | 20007 | — |
| USA015 | Clearwater | Florida | 33765 | — |
| USA076 | Gainesville | Florida | 32610 | — |
| USA082 | Jacksonville | Florida | 32224 | — |
| USA039 | Kissimmee | Florida | 34746 | — |
| USA072 | Leesburg | Florida | 34748 | — |
| USA037 | Miami | Florida | 33126 | — |
| USA019 | Miami Lakes | Florida | 33014 | — |
| USA049 | Naples | Florida | 34102 | — |
| USA052 | Orlando | Florida | 32825 | — |
| USA103 | Plantation | Florida | 33324 | — |
| USA084 | Sarasota | Florida | 34239 | — |
| USA089 | St. Petersburg | Florida | 33704 | — |
| USA074 | St. Petersburg | Florida | 33707 | — |
| USA120 | Tampa | Florida | 33606 | — |
| USA012 | Atlanta | Georgia | 30342 | — |
| USA053 | Augusta | Georgia | 30912 | — |
| USA073 | Chicago | Illinois | 60611 | — |
| USA061 | Maywood | Illinois | 60153 | — |
| USA115 | Hammond | Indiana | 46324 | — |
| USA063 | Iowa City | Iowa | 52242 | — |
| USA031 | Kansas City | Kansas | 66160 | — |
| USA020 | New Orleans | Louisiana | 70112 | — |
| USA051 | New Orleans | Louisiana | 70112 | — |
| USA003 | Baltimore | Maryland | 21224 | — |
| USA079 | Boston | Massachusetts | 02114 | — |
| USA064 | Springfield | Massachusetts | 01199 | — |
| USA010 | Rochester | Minnesota | 55905 | — |
| USA006 | Chesterfield | Missouri | 63017 | — |
| USA059 | St Louis | Missouri | 63110 | — |
| USA110 | Lincoln | Nebraska | 68510 | — |
| USA065 | Toms River | New Jersey | 08755 | — |
| USA066 | New Hyde Park | New York | 11042 | — |
| USA021 | New York | New York | 10017 | — |
| USA085 | New York | New York | 10032 | — |
| USA033 | Gastonia | North Carolina | 28054 | — |
| USA096 | Huntersville | North Carolina | 28078 | — |
| USA026 | Winston-Salem | North Carolina | 27103 | — |
| USA067 | Cincinnati | Ohio | 45267 | — |
| USA093 | Cleveland | Ohio | 44195 | — |
| USA023 | Portland | Oregon | 97239 | — |
| USA038 | DuBois | Pennsylvania | 15801 | — |
| USA046 | Philadelphia | Pennsylvania | 19104 | — |
| USA005 | Charleston | South Carolina | 29425 | — |
| USA036 | Rock Hill | South Carolina | 29732 | — |
| USA041 | Franklin | Tennessee | 37067 | — |
| USA109 | Nashville | Tennessee | 37232 | — |
| USA097 | Dallas | Texas | 75246 | — |
| USA050 | McKinney | Texas | 75069 | — |
| USA011 | San Antonio | Texas | 78258 | — |
| USA002 | Tyler | Texas | 75708 | — |
| USA034 | Williamsburg | Virginia | 23188 | — |
| USA088 | Vancouver | Washington | 98664 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 306 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT04594369, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Dec 16, 2025 · Synced Oct 26, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT04594369 live on ClinicalTrials.gov.