Efficacy, Safety and Tolerability of AZD9977 and Dapagliflozin in Participants With Heart Failure and Chronic Kidney Disease
Public ClinicalTrials.gov record NCT04595370. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase 2b, Randomised, Double-Blind, Active Controlled, Multi Centre Study to Evaluate the Efficacy, Safety and Tolerability of Oral AZD9977 and Dapagliflozin Treatment in Patients With Heart Failure and Chronic Kidney Disease
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
The purpose of the study is to evaluate the efficacy and safety of AZD9977 in combination with dapagliflozin compared with dapagliflozin alone and to assess the dose-response relationship, dapagliflozin alone and 3 doses of AZD9977 combined with dapagliflozin on urinary albumin to creatinine ratio (UACR). The study will be conducted in participants with heart failure (HF) with left ventricular ejection fraction (LVEF \[below 60%\]) and chronic kidney disease (CKD) with estimated glomerular filtration rate (eGFR \[between ≥ 20 and ≤ 60 mL/min/1.73 m\^2, with at least 20% of participants with eGFR ≥ 20 to \<30 mL/min/1.73\^2 and a maximum of 35% of participants with eGFR ≥ 45 mL/min/1.73 m\^2\]).
Study identification
- NCT ID
- NCT04595370
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 2
- Enrollment
- 153 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 21 Years to 130 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Jan 26, 2021 (Actual)
- Primary completion
- Sep 22, 2023 (Actual)
- Completion
- Sep 22, 2023 (Actual)
- Last update posted
- Nov 19, 2024
2021 – 2023
United States locations
- U.S. sites
- 26
- U.S. states
- 11
- U.S. cities
- 25
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Research Site | Beverly Hills | California | 90211 | — |
| Research Site | Fountain Valley | California | 92708 | — |
| Research Site | Northridge | California | 91324 | — |
| Research Site | South Gate | California | 90280 | — |
| Research Site | Hialeah | Florida | 33016 | — |
| Research Site | Homestead | Florida | 33032 | — |
| Research Site | Jacksonville | Florida | 32216 | — |
| Research Site | Miami | Florida | 33155 | — |
| Research Site | Ocala | Florida | 34474 | — |
| Research Site | Tampa | Florida | 33603 | — |
| Research Site | Augusta | Georgia | 30904 | — |
| Research Site | Columbus | Georgia | 31904 | — |
| Research Site | Baltimore | Maryland | 21287 | — |
| Research Site | Methuen | Massachusetts | 01844 | — |
| Research Site | St Louis | Missouri | 63136 | — |
| Research Site | The Bronx | New York | 10455 | — |
| Research Site | New Bern | North Carolina | 28562 | — |
| Research Site | Rapid City | South Dakota | 57701 | — |
| Research Site | Memphis | Tennessee | 38119 | — |
| Research Site | Houston | Texas | 77087 | — |
| Research Site | Houston | Texas | 77099 | — |
| Research Site | Kingwood | Texas | 77339 | — |
| Research Site | McKinney | Texas | 75069 | — |
| Research Site | San Antonio | Texas | 78207 | — |
| Research Site | Sherman | Texas | 75092 | — |
| Research Site | Webster | Texas | 77598 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 130 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT04595370, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Nov 19, 2024 · Synced Oct 24, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT04595370 live on ClinicalTrials.gov.