Clinical Trials Finder
Independent ClinicalTrials.gov directory
ClinicalTrials.gov record
Recruiting Phase 2Phase 3 Interventional

Phase 2 Trial of Adagrasib Monotherapy and in Combination With Pembrolizumab and a Phase 3 Trial of Adagrasib in Combination in Patients With a KRAS G12C Mutation KRYSTAL-7

ClinicalTrials.gov ID: NCT04613596

Public ClinicalTrials.gov record NCT04613596. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

View official ClinicalTrials.gov record → Back to search
ClinicalTrials.gov public records Last synced Apr 22, 2026, 9:00 AM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Official title

A Phase 2 Trial of Adagrasib Monotherapy and in Combination With Pembrolizumab and a Phase 3 Trial of Adagrasib in Combination With Pembrolizumab Versus Pembrolizumab in Patients With Advanced Non-Small Cell Lung Cancer With KRAS G12C Mutation

Study identification

NCT ID
NCT04613596
Recruitment status
Recruiting
Study type
Interventional
Phase
Phase 2, Phase 3
Lead sponsor
Mirati Therapeutics Inc.
Industry
Enrollment
806 participants

Conditions and interventions

Interventions

  • Adagrasib Drug
  • Pembrolizumab Drug

Drug

Eligibility (public fields only)

Age range
18 Years and older
Sex
All
Healthy volunteers
Not listed

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date
Dec 1, 2020
Primary completion
Oct 30, 2028
Completion
Oct 30, 2029
Last update posted
Mar 17, 2026

2020 – 2029

United States locations

U.S. sites
220
U.S. states
36
U.S. cities
171
Facility City State ZIP Site status
Local Institution - 007-556-A Goodyear Arizona 85395 Not yet recruiting
USOR - Arizona Oncology - Prescott Valley Prescott Valley Arizona 86301 Recruiting
Local Institution - 007-568-A Safford Arizona 85546 Not yet recruiting
Local Institution - 007-568-B Safford Arizona 85546 Not yet recruiting
Local Institution - 007-568-C Safford Arizona 85546 Not yet recruiting
Local Institution - 007-568-D Safford Arizona 85546 Not yet recruiting
Local Institution - 007-568-E Safford Arizona 85546 Not yet recruiting
Arizona Clinical Research Center Tucson Arizona 85715 Recruiting
Highlands Oncology Group - Springdale Springdale Arkansas 72762 Recruiting
Providence - Saint Joseph Home Health - Anaheim Anaheim California 92805 Recruiting
The Oncology Institute of Hope and Innovation - Corporate Office Cerritos California 90703 Recruiting
Local Institution - 007-777 Fountain Valley California 92708 Not yet recruiting
Local Institution - 007-778 Laguna Hills California 92653 Not yet recruiting
Local Institution - 007-898-B Long Beach California 90805 Not yet recruiting
MemorialCare - Long Beach Medical Center Long Beach California 90806 Recruiting
TRIO - Cancer & Blood Specialty Clinic - Los Alamitos Los Alamitos California 90720 Recruiting
Local Institution - 007-579 Los Angeles California 90048 Withdrawn
Local Institution - Unk045 Rancho Mirage California 92270 Active, not recruiting
San Francisco Veterans Affairs Medical Center San Francisco California 94121 Recruiting
UCSF Helen Diller Family Comprehensive Cancer Center San Francisco California 94158 Recruiting
Local Institution - 007-898-C Santa Ana California 92705 Not yet recruiting
Providence Medical Group - Santa Rosa Santa Rosa California 95403 Recruiting
Stockton Hematology Oncology Medical Group (SHOMG) - Stockton (Suite B) Stockton California 95219 Recruiting
Local Institution - 007-898-A Whittier California 90602 Not yet recruiting
Local Institution - 007-872-H Aurora Colorado 80012 Not yet recruiting
Local Institution - 007-872-D Boulder Colorado 80303 Not yet recruiting
Local Institution - 007-872-L Centennial Colorado 80112 Not yet recruiting
Local Institution - 007-872-C Colorado Springs Colorado 80907 Not yet recruiting
Local Institution - 007-872-K Colorado Springs Colorado 80920 Not yet recruiting
Local Institution - 007-872-E Denver Colorado 80218 Not yet recruiting
Local Institution - 007-872-I Denver Colorado 80220 Not yet recruiting
Local Institution - 007-872-A Lakewood Colorado 80228 Not yet recruiting
Local Institution - 007-872-J Littleton Colorado 80218 Not yet recruiting
USOR - Rocky Mountain Cancer Centers - Lone Tree Lone Tree Colorado 80124 Recruiting
Local Institution - 007-872-G Longmont Colorado 80504 Not yet recruiting
Local Institution - 007-872-B Pueblo Colorado 81003 Not yet recruiting
Local Institution - 007-872-F Thornton Colorado 80260 Not yet recruiting
Eastern Connecticut Hematology and Oncology Associates Norwich Connecticut 06360 Recruiting
Local Institution - 007-5476 Washington D.C. District of Columbia 20010 Not yet recruiting
GenesisCare USA Aventura Florida 33180 Recruiting
Bay Pines Veterans Affairs Healthcare System Bay Pines Florida 33744 Recruiting
Local Institution - 007-922-A Bonita Springs Florida 34135 Not yet recruiting
Local Institution - 007-922-D Bradenton Florida 34211 Not yet recruiting
Local Institution - 007-922-E Cape Coral Florida 33909 Not yet recruiting
Local Institution - 007-896-A Celebration Florida 34747 Not yet recruiting
Local Institution - 007-926-B Daytona Beach Florida 32117 Not yet recruiting
Local Institution - 007-562-B Fleming Island Florida 32003 Not yet recruiting
SCRI - Florida Cancer Specialists - South Region Research Office Fort Myers Florida 33901 Recruiting
Local Institution - 007-922-B Fort Myers Florida 33905 Not yet recruiting
Local Institution - 007-922-C Fort Myers Florida 33908 Not yet recruiting
21st Century Oncology of Jacksonville - North Lee Street Jacksonville Florida 32204 Recruiting
Local Institution - 007-562-D Jacksonville Florida 32204 Not yet recruiting
Local Institution - 007-562-E Jacksonville Florida 32207 Not yet recruiting
Local Institution - 007-562-G Jacksonville Florida 32218 Not yet recruiting
Local Institution - 007-829 Jacksonville Florida 32224 Withdrawn
Cancer Specialists of North Florida - Southpoint Jacksonville Florida 32256 Recruiting
Local Institution - 007-562-C Jacksonville Florida 32258 Not yet recruiting
Local Institution - 007-562-F Jacksonville Beach Florida 32250 Not yet recruiting
Miami Veterans Affairs Healthcare System Miami Florida 33125-1624 Recruiting
Local Institution - 007-922-F Naples Florida 34102 Not yet recruiting
Local Institution - 007-922-G Naples Florida 34102 Not yet recruiting
AdventHealth Orlando Orlando Florida 32803 Recruiting
USOR - Woodlands Medical Specialists Pensacola Florida 32503 Recruiting
Local Institution - 007-922-H Port Charlotte Florida 33980 Not yet recruiting
Local Institution - 007-562-A Saint Augustine Florida 32086 Not yet recruiting
Local Institution - 007-922-I Sarasota Florida 34232 Not yet recruiting
Local Institution - 007-922-J Sarasota Florida 34236 Not yet recruiting
Local Institution - 007-926-D Stuart Florida 34994 Not yet recruiting
Local Institution - 007-924-A Tallahassee Florida 32308 Not yet recruiting
SCRI - Florida Cancer Specialists - Tallahassee Cancer Center Tallahassee Florida 32308 Recruiting
James A. Haley Veterans Hospital Tampa Florida 33612 Recruiting
Local Institution - Unk065 Tampa Florida 33612 Active, not recruiting
Local Institution - 007-922-L Venice Florida 34285 Not yet recruiting
Local Institution - 007-922-K Venice Florida 34292 Not yet recruiting
Local Institution - 007-926-C Vero Beach Florida 32960 Not yet recruiting
Local Institution - 007-926-A Wellington Florida 33414 Not yet recruiting
SCRI - Florida Cancer Specialists - West Palm Beach West Palm Beach Florida 33401 Recruiting
Local Institution - Unk072 Weston Florida 33331 Active, not recruiting
University Cancer & Blood Center (UCBC) - Athens Athens Georgia 30607 Recruiting
Local Institution - Unk052 Atlanta Georgia 30318 Active, not recruiting
Local Institution - 007-786-C Carrollton Georgia 30117 Not yet recruiting
Local Institution - 007-786-A Cartersville Georgia 30121 Not yet recruiting
Local Institution - 007-786-D Douglasville Georgia 30134 Not yet recruiting
Local Institution - 007-786-B Hiram Georgia 30141 Not yet recruiting
Central Georgia Cancer Care - Macon Macon Georgia 31201 Recruiting
Northwest Georgia Oncology Centers Wellstar - Marietta Marietta Georgia 30060 Recruiting
Local Institution - 007-897 Honolulu Hawaii 96813 Withdrawn
Local Institution - Unk005 Honolulu Hawaii 96813 Active, not recruiting
Local Institution - 007-883-A Arlington Heights Illinois 60005 Not yet recruiting
Local Institution - 007-955 Chicago Illinois 60612 Withdrawn
University of Chicago Chicago Illinois 60637 Recruiting
Loyola University Medical Center Maywood Illinois 60153 Recruiting
USOR - Illinois Cancer Specialists - Niles Niles Illinois 60714 Recruiting
Advocate Medical Group Oncology Park Ridge Illinois 60068 Recruiting
Local Institution - Unk061 Peoria Illinois 61603-3200 Active, not recruiting
Goshen Center for Cancer Care Goshen Indiana 46526 Recruiting
Local Institution - 007-942-B Chanute Kansas 66720 Not yet recruiting
Local Institution - 007-942-D El Dorado Kansas 67042 Not yet recruiting
Local Institution - 007-942-E Independence Kansas 67301 Not yet recruiting
Local Institution - 007-942-F Kingman Kansas 67068 Not yet recruiting
Local Institution - 007-942-G Liberal Kansas 67901 Not yet recruiting
Local Institution - 007-942-H McPherson Kansas 67460 Not yet recruiting
MidAmerica Cancer Care - Research Merriam Kansas 66204 Recruiting
Local Institution - 007-942-I Newton Kansas 67114 Not yet recruiting
Local Institution - 007-942-J Parsons Kansas 67357 Not yet recruiting
Local Institution - 007-942-K Pratt Kansas 67124 Not yet recruiting
Local Institution - 007-942-L Salina Kansas 67401 Not yet recruiting
Local Institution - 007-942-M Wellington Kansas 67152 Not yet recruiting
Local Institution - Unk032 Westwood Kansas 66205 Active, not recruiting
Local Institution - 007-942-A Wichita Kansas 67208 Not yet recruiting
Cancer Center of Kansas - Wichita - Heritage Plaza Wichita Kansas 67214 Recruiting
Local Institution - 007-942-N Winfield Kansas 67156 Not yet recruiting
Lexington Medical Cancer Center Hematology/Oncology Lexington Kentucky 40503 Recruiting
University of Louisville Louisville Kentucky 40202 Recruiting
Local Institution - 007-388-A Louisville Kentucky 40245 Not yet recruiting
Local Institution - Unk011 Baton Rouge Louisiana 70809 Active, not recruiting
Local Institution - 007-994-A Covington Louisiana 70433 Not yet recruiting
Pontchartrain Cancer Center - Covington Office Covington Louisiana 70433 Recruiting
The Sidney Kimmel Comprehensive Cancer Center Baltimore Maryland 21231 Recruiting
Dana-Farber Cancer Institute Boston Massachusetts 02215 Recruiting
Dana-Farber Cancer Institute at St. Elizabeths Medical Center Brighton Massachusetts 02135 Recruiting
Brigham and Womens/Mass General Health Care Center at Foxborough Foxborough Massachusetts 02035 Recruiting
Dana-Farber Cancer Institute - Merrimack Valley Methuen Massachusetts 01844 Recruiting
Dana-Farber Brigham and Womens Cancer Center at Milford Regional Milford Massachusetts 01757 Recruiting
Dana-Farber Brigham Cancer Center at South Shore Health South Weymouth Massachusetts 02190 Recruiting
USOR - Minnesota Oncology - Burnsville Burnsville Minnesota 55337 Recruiting
Local Institution - 007-589A Edina Minnesota 55435 Not yet recruiting
Local Institution - Unk006 Minneapolis Minnesota 55404 Active, not recruiting
Local Institution - 007-822 Minneapolis Minnesota 55455 Withdrawn
Local Institution - 007-830 Rochester Minnesota 55905 Withdrawn
Jackson Oncology Associates - The Hederman Cancer Center Jackson Mississippi 39202 Recruiting
Local Institution - 007-590D Grand Island Nebraska 68803 Not yet recruiting
Local Institution - 007-590A Omaha Nebraska 68114-4108 Not yet recruiting
Local Institution - 007-590B Omaha Nebraska 68124 Not yet recruiting
Nebraska Cancer Specialists - Midwest Cancer Center - Legacy Omaha Nebraska 68130 Recruiting
Local Institution - 007-590C Papillion Nebraska 68046 Not yet recruiting
OptumCare Nevada Las Vegas Nevada 89106 Recruiting
Local Institution - 007-938A Las Vegas Nevada 89148 Not yet recruiting
Local Institution - 007-938B Las Vegas Nevada 89148 Not yet recruiting
Local Institution - 007-993 Belleville New Jersey 07109 Withdrawn
Astera Cancer Care - East Brunswick East Brunswick New Jersey 08816 Recruiting
John Theurer Cancer Center Hackensack New Jersey 07601 Recruiting
Local Institution - 007-975-A Somerset New Jersey 08873-5002 Not yet recruiting
Local Institution - 007-975-B Somerset New Jersey 08873-5002 Not yet recruiting
Local Institution - 007-975-C Somerset New Jersey 08873-5002 Not yet recruiting
Local Institution - 007-975-D Somerset New Jersey 08873-5002 Not yet recruiting
Holy Name Medical Center Teaneck New Jersey 07666 Recruiting
New York Oncology Hematology - Albany Medical Center Albany New York 12208 Recruiting
Local Institution - Unk077 Rhinebeck New York 12572 Active, not recruiting
Montefiore Medical Center The Bronx New York 10467 Recruiting
Duke University Medical Center Durham North Carolina 27710 Recruiting
Local Institution - 007-893-B Cincinnati Ohio 45211 Not yet recruiting
USOR - Oncology Hematology Care - Blue Ash Cincinnati Ohio 45242 Recruiting
Local Institution - 007-893-C Cincinnati Ohio 45245 Not yet recruiting
University Hospitals Cleveland Medical Center Cleveland Ohio 44106 Recruiting
Mark H. Zangmeister Cancer Center Columbus Ohio 43219 Recruiting
Local Institution - 007-893-A Fairfield Ohio 45014 Not yet recruiting
Kettering Health Cancer Center - Main Campus Kettering Ohio 45429 Recruiting
Tricounty Hematology and Oncology - Massillon Massillon Ohio 44646 Recruiting
USOR - Willamette Valley Cancer Institute and Research Center - Eugene Eugene Oregon 97401 Recruiting
Local Institution - 007-885B Portland Oregon 97213 Not yet recruiting
Local Institution - 007-885A Portland Oregon 97227 Not yet recruiting
Oregon Oncology Specialists Salem Oregon 97301 Recruiting
Local Institution - 007-885C Tigard Oregon 97223 Not yet recruiting
Local Institution - Unk041 Allentown Pennsylvania 18103-6218 Active, not recruiting
Veterans Affairs Pittsburgh Healthcare System - University Drive Campus Pittsburgh Pennsylvania 15240 Recruiting
Local Institution - 007-960 Providence Rhode Island 02903 Withdrawn
Local Institution - Unk038 Charleston South Carolina 29414 Active, not recruiting
Local Institution - 007-5475 Spartanburg South Carolina 29303 Withdrawn
Avera Cancer Institute Sioux Falls South Dakota 57105 Recruiting
Local Institution - 007-928-L Dickson Tennessee 37055 Not yet recruiting
Local Institution - 007-928-J Franklin Tennessee 37067 Not yet recruiting
Local Institution - 007-928-G Gallatin Tennessee 37066 Not yet recruiting
West Cancer Center & Research Institute - East Campus Germantown Tennessee 38138 Recruiting
Local Institution - 007-928-A Hendersonville Tennessee 37075 Not yet recruiting
Local Institution - 007-928-D Hermitage Tennessee 37076 Not yet recruiting
Local Institution - 007-928-H Lebanon Tennessee 37090 Not yet recruiting
Local Institution - 007-928-F Murfreesboro Tennessee 37129 Not yet recruiting
Local Institution - 007-928-B Nashville Tennessee 37203 Not yet recruiting
Tennessee Oncology - Nashville - Centennial Clinic - Medical Oncology Nashville Tennessee 37203 Recruiting
Local Institution - 007-928-K Nashville Tennessee 37205 Not yet recruiting
Local Institution - 007-928-E Nashville Tennessee 37207 Not yet recruiting
Local Institution - 007-928-C Nashville Tennessee 37211 Not yet recruiting
Local Institution - 007-928-M Shelbyville Tennessee 37160 Not yet recruiting
Local Institution - 007-928-I Smyrna Tennessee 37167 Not yet recruiting
Local Institution - 007-554B Abilene Texas 79606 Not yet recruiting
Local Institution - 007-554G Amarillo Texas 79124 Not yet recruiting
Local Institution - 007-879-A Arlington Texas 76012 Not yet recruiting
Local Institution - 007-879-B Arlington Texas 76014 Not yet recruiting
Local Institution - 007-892-B Austin Texas 78705 Not yet recruiting
Local Institution - 007-892-A Austin Texas 78731 Not yet recruiting
USOR - Texas Oncology - Dallas Fort Worth (DFW) - South Austin Austin Texas 78745 Recruiting
Local Institution - 007-879-C Bedford Texas 76022 Not yet recruiting
Local Institution - Unk059 Dallas Texas 75204 Active, not recruiting
Local Institution - 007-592 Dallas Texas 75216 Withdrawn
Texas Oncology - Dallas Fort Worth (DFW) - Baylor Charles A. Sammons Cancer Center Dallas Texas 75246 Recruiting
USOR - Texas Oncology Northeast Texas - Denison Denison Texas 75020 Recruiting
Local Institution - 007-554E El Paso Texas 79902 Not yet recruiting
Local Institution - 007-554C El Paso Texas 79915 Not yet recruiting
Local Institution - 007-554F El Paso Texas 79938 Not yet recruiting
USOR - Texas Oncology - Fredericksburg Fredericksburg Texas 78624 Recruiting
Local Institution - 007-848 Houston Texas 77030 Active, not recruiting
Local Institution - 007-999 Irving Texas 75063 Not yet recruiting
Local Institution - 007-890-B Longview Texas 75601 Not yet recruiting
Local Institution - 007-554A Midland Texas 79701 Not yet recruiting
USOR - Texas Oncology - Dallas Fort Worth (DFW) - Odessa West Texas Cancer Center Odessa Texas 79761 Recruiting
USOR - Texas Oncology - The Woodlands The Woodlands Texas 77380 Recruiting
Local Institution - 007-890-A Tyler Texas 75702 Not yet recruiting
Local Institution - 007-554D Wichita Falls Texas 76310 Not yet recruiting
Local Institution - 007-912 Salt Lake City Utah 84112 Withdrawn
Local Institution - 007-814-A Alexandria Virginia 22304 Not yet recruiting
Local Institution - 007-814-D Arlington Virginia 22201 Not yet recruiting
USOR - Virginia Cancer Specialists - Fairfax Office Fairfax Virginia 22031 Recruiting
Local Institution - 007-814-B Gainesville Virginia 20155 Not yet recruiting
Local Institution - 007-814-C Leesburg Virginia 20176 Not yet recruiting
Virginia Cancer Institute - West End Richmond Virginia 23229 Recruiting
USOR - Northwest Cancer Specialists, P.C. dba Compass Oncology - Vancouver Cancer Center Vancouver Washington 98684 Recruiting
Local Institution - Unk064 Huntington West Virginia 25705 Active, not recruiting
Local Institution - Unk057 Madison Wisconsin 53715 Active, not recruiting
Local Institution - Unk068 Madison Wisconsin 53792 Active, not recruiting

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

Non-U.S. locations

This page focuses on the U.S. directory. The official record also lists 544 non-U.S. sites.

About this trial record page

What this page shows
Public field values for ClinicalTrials.gov record NCT04613596, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do
No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from
Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh
Last update posted Mar 17, 2026 · Synced Apr 22, 2026

Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.

Open the official record

The complete protocol, eligibility criteria, and contact information for NCT04613596 live on ClinicalTrials.gov.

View official ClinicalTrials.gov record →