A Study of JNJ-63733657 in Participants With Early Alzheimer's Disease
Public ClinicalTrials.gov record NCT04619420. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
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Official title
A Randomized, Double-blind, Placebo-controlled, Parallel-group, Multicenter Study With a Long-Term Extension Treatment Period to Assess the Efficacy and Safety of JNJ-63733657, an Anti-tau Monoclonal Antibody, in Participants With Early Alzheimer's Disease
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
The primary purpose of this study is to evaluate the effect of JNJ-63733657 versus placebo on clinical decline as measured by the Integrated Alzheimer's Disease Rating Scale (iADRS), a composite of cognition and function.
Study identification
- NCT ID
- NCT04619420
- Recruitment status
- Terminated
- Study type
- Interventional
- Phase
- Phase 2
- Enrollment
- 523 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 55 Years to 80 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Jan 6, 2021 (Actual)
- Primary completion
- Oct 17, 2025 (Actual)
- Completion
- Mar 3, 2026 (Actual)
- Last update posted
- Nov 5, 2026
2021 – 2026
United States locations
- U.S. sites
- 55
- U.S. states
- 21
- U.S. cities
- 50
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| University of Alabama Birmingham | Birmingham | Alabama | 35233 | — |
| Dignity Health | Phoenix | Arizona | 85013 | — |
| Irvine Clinical Research | Irvine | California | 92614 | — |
| University of California San Diego Medical Center | La Jolla | California | 92037 | — |
| University of California - Los Angeles | Los Angeles | California | 90095 | — |
| Stanford University Medical Center | Palo Alto | California | 94304 | — |
| Pacific Research Network Prn | San Diego | California | 92103 | — |
| Syrentis Clinical Research | Santa Ana | California | 92705 | — |
| Yale University School Of Medicine | New Haven | Connecticut | 06510 | — |
| Georgetown University Clinical Research Unit CRU | Washington D.C. | District of Columbia | 20007 | — |
| JEM Research LLC | Atlantis | Florida | 33462 | — |
| Brain Matters Research | Delray Beach | Florida | 33445 | — |
| Neuropsychiatric Research Center of SWFL | Fort Myers | Florida | 33912 | — |
| Clinical NeuroScience Solutions Inc | Jacksonville | Florida | 32256 | — |
| Alphab Global Research | Jupiter | Florida | 33458 | — |
| K2 Medical Research | Maitland | Florida | 32751 | — |
| Tandem Intermediate LLC | Maitland | Florida | 32751 | — |
| Merritt Island Medical Research, LLC | Merritt Island | Florida | 32952 | — |
| University of Miami Miller School of Medicine | Miami | Florida | 33136 | — |
| Miami Jewish Health System | Miami | Florida | 33137 | — |
| Aqualane Clinical Research | Naples | Florida | 34105 | — |
| Renstar Medical Research | Ocala | Florida | 34470 | — |
| Sensible Healthcare | Ocoee | Florida | 34761 | — |
| Axiom Clinical Research of Florida | Tampa | Florida | 33609 | — |
| Stedman Clinical Trials | Tampa | Florida | 33613 | — |
| University of South Florida - Health Byrd Alzheimer Institute | Tampa | Florida | 33613 | — |
| Charter Research | The Villages | Florida | 32162 | — |
| ClinCloud Clinical Research | Viera | Florida | 32904 | — |
| Alzheimers Research and Treatment Center | Wellington | Florida | 33414 | — |
| Palm Beach Neurology and Premier Research Institute | West Palm Beach | Florida | 33407 | — |
| Conquest Research | Winter Park | Florida | 32789 | — |
| The Emory Clinic | Atlanta | Georgia | 30329 | — |
| Sandhill Research | Decatur | Georgia | 30030 | — |
| Great Lakes Clinical Trials | Chicago | Illinois | 60640 | — |
| Alexian Brothers Medical Center - Neuroscience Research Institute | Elk Grove Village | Illinois | 60007 | — |
| Indiana University | Indianapolis | Indiana | 46202 | — |
| Massachusetts General Hospital | Boston | Massachusetts | 02114 | — |
| Beth Israel Deaconess Medical Center | Boston | Massachusetts | 02215 | — |
| Anil Nair dba Alzheimer's Disease Center | Braintree | Massachusetts | 02184 | — |
| Hattiesburg Clinic | Hattiesburg | Mississippi | 39401 | — |
| Washington University School Of Medicine | St Louis | Missouri | 63110 | — |
| NeuroCognitive Institute | Mount Arlington | New Jersey | 07856 | — |
| Princeton Medical Institute | Princeton | New Jersey | 08540 | — |
| Advanced Memory Research Institute of NJ | Toms River | New Jersey | 08755 | — |
| Neurological Associates of Albany, PC | Albany | New York | 12208 | — |
| Velocity Clinical Research | East Syracuse | New York | 13057 | — |
| New York University Medical Center | New York | New York | 10016 | — |
| Wake Forest Health Sciences | Winston-Salem | North Carolina | 27157 | — |
| Cleveland Clinic Lou Revo Center for Brain Health | Cleveland | Ohio | 44195 | — |
| Wexner Medical Center at the Ohio State University | Columbus | Ohio | 43221 | — |
| Keystone Clinical Studies LLC | Plymouth Meeting | Pennsylvania | 19462 | — |
| Brown University School of Medicine | Providence | Rhode Island | 02906 | — |
| The University of Texas Health Science Center at Houston | Houston | Texas | 77054 | — |
| Memory Clinic Inc | Bennington | Vermont | 05201 | — |
| University of Virginia | Charlottesville | Virginia | 22903 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 67 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT04619420, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Nov 5, 2026 · Synced Nov 6, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT04619420 live on ClinicalTrials.gov.