ClinicalTrials.gov record
Tomivosertib Combined With Pembrolizumab in Subjects With PD-L1 Positive NSCLC (KICKSTART)
ClinicalTrials.gov ID: NCT04622007
Public ClinicalTrials.gov record NCT04622007. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Randomized, Double-Blind, Placebo-Controlled Trial of Tomivosertib in Combination With Anti-PD-(L)1 Therapy in Subjects With NSCLC as First Line Therapy or When Progressing on Single-Agent First-Line Anti PD (L)1 Therapy
Study identification
- NCT ID
- NCT04622007
- Recruitment status
- Not listed
- Study type
- Interventional
- Phase
- Phase 2
- Lead sponsor
- Effector Therapeutics
- Industry
- Enrollment
- 68 participants
Conditions and interventions
Conditions
Interventions
- Tomivosertib Drug
- Pembrolizumab Biological
- Pemetrexed Drug
Drug · Biological
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Jun 1, 2021
- Primary completion
- Oct 13, 2024
- Completion
- Dec 8, 2024
- Last update posted
- Apr 29, 2024
2021 – 2024
United States locations
- U.S. sites
- 131
- U.S. states
- 24
- U.S. cities
- 108
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Southern Cancer Center | Daphne | Alabama | 36526 | — |
| Southern Cancer Center, PC (Mobile Infirmary Circle) | Mobile | Alabama | 36607 | — |
| Southern Cancer Center, PC (Airport Blvd) | Mobile | Alabama | 36608 | — |
| Southern Cancer Center, PC (Dauphin St) | Mobile | Alabama | 36608 | — |
| Arizona Oncology Associates, PC - HAL (W Bell Rd) | Glendale | Arizona | 85308 | — |
| Arizona Oncology Associates, PC - NAHOA (W. McDowell) | Goodyear | Arizona | 85395 | — |
| Arizona Oncology Associates, PC - HAL | Phoenix | Arizona | 85016 | — |
| Arizona Oncology Associates, PC-NAHOA (N. Windsong) | Prescott Valley | Arizona | 86314 | — |
| Arizona Oncology Associates (N. Pima Rd) | Scottsdale | Arizona | 85258 | — |
| Arizona Oncology Associates, PC - HAL | Scottsdale | Arizona | 85258 | — |
| Arizona Oncology Associates, PC - HAL | Tempe | Arizona | 85284 | — |
| Arizona Oncology Associates, PC - HOPE (W. Orange Grove) | Tucson | Arizona | 85704 | — |
| Arizona Oncology Associates, PC - HOPE (W. Rudasill Rd) | Tucson | Arizona | 85704 | — |
| Arizona Oncology Associates, PC - HOPE | Tucson | Arizona | 85711 | — |
| Arizona Oncology Associates, PC - HOPE (West St.) | Tucson | Arizona | 85745 | — |
| University of California, Los Angeles (UCLA) - Alhambra | Alhambra | California | 91801 | — |
| Comprehensive Blood And Cancer Center | Bakersfield | California | 93309 | — |
| TOI Clincal Research | Cerritos | California | 90703 | — |
| California Cancer Associates for Research & Excellence (San Diego Pacific Oncology and Hematology Associates) - Encinitas | Encinitas | California | 92024 | — |
| City of Hope - Long Beach Elm | Long Beach | California | 90813 | — |
| Cancer and Blood Specialty Clinic | Los Alamitos | California | 90720 | — |
| University of California, Los Angeles (UCLA) | Los Angeles | California | 90025 | — |
| USC Norris Comprehensive Cancer Center | Los Angeles | California | 90033 | — |
| Mercy Cancer Center | Merced | California | 95340 | — |
| Mercy UC Davis Center Center | Merced | California | 95340 | — |
| Keck Medicine of USC Norris Oncology/Hematology | Newport Beach | California | 92663 | — |
| University of California - Irvine Medical Center | Orange | California | 92868 | — |
| University of California, Los Angeles (UCLA) - Porter Ranch | Porter Ranch | California | 91326 | — |
| St. Mary's Medical Center - San Francisco | San Francisco | California | 94117 | — |
| Dignity Health- SLO Oncology and Hematology | San Luis Obispo | California | 93401 | — |
| University of California, Los Angeles (UCLA) - San Luis Obispo | San Luis Obispo | California | 93401 | — |
| California Cancer Associates for Research & Excellence (San Diego Pacific Oncology and Hematology Associates) - San Marcos Cancer Center | San Marcos | California | 92069 | — |
| Mission Hope Cancer Center | Santa Maria | California | 93454 | — |
| Dignity Health St. Joseph's Medical Center Stockton | Stockton | California | 95204 | — |
| Stockton Hematology Oncology Medical Group (Stockton) | Stockton | California | 95204 | — |
| Santa Clarita - UCLA | Valencia | California | 91355 | — |
| Ventura - UCLA | Ventura | California | 93003 | — |
| PIH Health Hospital - Whittier | Whittier | California | 90602 | — |
| Rocky Mountain Cancer Centers (South Potomac St) | Aurora | Colorado | 80012 | — |
| Rocky Mountain Cancer Centers (Arapahoe Ave) | Boulder | Colorado | 80303 | — |
| Rocky Mountain Cancer Centers (E Arapahoe Rd) | Centennial | Colorado | 80112 | — |
| Rocky Mountain Cancer Centers | Colorado Springs | Colorado | 80907 | — |
| Rocky Mountain Cancer Centers, Colorado Springs CO (Peregrine) | Colorado Springs | Colorado | 80923 | — |
| Rocky Mountain Cancer Centers (Williams St) | Denver | Colorado | 80218 | — |
| Rocky Mountain Cancer Centers (E. Hale Parkway) | Denver | Colorado | 80220 | — |
| Rocky Mountain Cancer Centers (West 2nd Place) | Lakewood | Colorado | 80228 | — |
| Rocky Mountain Cancer Centers (W Dry Creek Circle) | Littleton | Colorado | 80120-4413 | — |
| Rocky Mountain Cancer Centers (Ridge Gate Parkway) | Lone Tree | Colorado | 80124 | — |
| Rocky Mountain Cancer Centers (E. Ken Pratt Blvd) | Longmont | Colorado | 80504 | — |
| Rocky Mountain Cancer Centers (Ridge Gate Parkway) | Pueblo | Colorado | 81008 | — |
| Rocky Mountain Cancer Centers (Huron St) | Thornton | Colorado | 80260 | — |
| ASCLEPES Research Centers | Brooksville | Florida | 34613 | — |
| Memorial Healthcare System | Hollywood | Florida | 33021 | — |
| Cancer Care Centers of Brevard (Melbourne) | Melbourne | Florida | 32935 | — |
| University of Florida (UF) Health Cancer Center - Orlando Health | Orlando | Florida | 32806 | — |
| Cancer Care Centers of Brevard | Palm Bay | Florida | 32901 | — |
| Memorial Cancer Institute at Memorial West Hospital | Pembroke Pines | Florida | 33028 | — |
| Woodlands Medical Specialists, PA | Pensacola | Florida | 32503 | — |
| John B. Amos Cancer Center | Columbus | Georgia | 31904 | — |
| Fort Wayne Medical Oncology and Hematology | Fort Wayne | Indiana | 46804 | — |
| Baptist Health - Lexington | Lexington | Kentucky | 40503 | — |
| Baptist Health - Louisville | Louisville | Kentucky | 40207 | — |
| Luminus Health Research Institute, Inc. | Annapolis | Maryland | 21401 | — |
| Maryland Oncology Hematology, P.A. (Rockledge Dr) | Bethesda | Maryland | 20817 | — |
| Maryland Oncology Hematology, P.A. (Matapeake Business Dr) | Brandywine | Maryland | 20613 | — |
| Maryland Oncology Hematology, P.A. (Woodyard Rd) | Clinton | Maryland | 20735 | — |
| Maryland Oncology Hematology, P.A | Columbia | Maryland | 21044 | — |
| Maryland Oncology Hematology, P.A. (Thomas Johnson Dr) | Frederick | Maryland | 21702 | — |
| Maryland Oncology Hematology, P.A. (Good Luck Rd) | Lanham | Maryland | 20706 | — |
| Maryland Oncology Hematology, P.A. (Medical Center Drive) | Rockville | Maryland | 20850 | — |
| Maryland Oncology Hematology, P.A. (Healing Way) | Silver Spring | Maryland | 20904 | — |
| Tufts Medical Center | Boston | Massachusetts | 02111 | — |
| Henry Ford Hospital | Detroit | Michigan | 48202 | — |
| Metro Minnesota CCOP | Saint Louis Park | Minnesota | 55416 | — |
| Mercy Cancer Center | Joplin | Missouri | 64804 | — |
| Washington University School of Medicine | St Louis | Missouri | 63110 | — |
| St. Vincent Frontier Cancer Center | Billings | Montana | 59102 | — |
| Broome Oncology | Binghamton | New York | 13905 | — |
| Broome Oncology, LLC (Harrison St) | Johnson City | New York | 13790 | — |
| Columbia University Medical Center | New York | New York | 10032 | — |
| Columbia University | New York | New York | 10032 | — |
| Messino Cancer Center | Asheville | North Carolina | 28806 | — |
| Mercy Hematology and Oncology Associates | Canton | Ohio | 44708 | — |
| Gabrail Cancer Center | Canton | Ohio | 44718 | — |
| VA Medical Center- Dayton | Dayton | Ohio | 45428 | — |
| Tri-County Hematology & Oncology Associates | Dover | Ohio | 44622 | — |
| Kettering Medical Center | Kettering | Ohio | 45429 | — |
| Tri-County Hematology & Oncology Associates - Massillon | Massillon | Ohio | 44646 | — |
| University of Toledo | Toledo | Ohio | 43614 | — |
| Willamette Valley Cancer Institute and Research Ctr | Eugene | Oregon | 97401 | — |
| Providence Portland Medical Center | Portland | Oregon | 97213 | — |
| Prisma Health Cancer Institute | Greenville | South Carolina | 29615 | — |
| Prairie Lakes Cancer Center | Watertown | South Dakota | 57201 | — |
| Texas Oncology - West Texas (Antilley Rd) | Abilene | Texas | 79606-5208 | — |
| Texas Oncology-Austin Midtown (W. 38th St) | Austin | Texas | 78705 | — |
| Texas Oncology-Austin Central (Balcones Dr.) | Austin | Texas | 78731 | — |
| Texas Oncology - South Austin | Austin | Texas | 78745 | — |
| Texas Oncology Gulf Coast - Beaumont (College St) | Beaumont | Texas | 77701 | — |
| Texas Oncology Gulf Coast - Beaumont Mamie McFaddin Ward Cancer Center | Beaumont | Texas | 77702 | — |
| Texas Oncology - Bedford | Bedford | Texas | 76022 | — |
| Texas Oncology-Carrollton (N Josey Lane) | Carlton | Texas | 75010 | — |
| Texas Oncology - Dallas Presbyterian Hospital | Dallas | Texas | 75231 | — |
| Texas Oncology-Baylor Charles A. Sammons Cancer Center | Dallas | Texas | 75246 | — |
| Texas Oncology - Denton | Denton | Texas | 76201 | — |
| Texas Oncology - West Texas (Grandview Ave) | El Paso | Texas | 79902 | — |
| Texas Oncology - West Texas | El Paso | Texas | 79902 | — |
| Texas Oncology - West Texas (Gateway Blvd E) | El Paso | Texas | 79915 | — |
| Texas Oncology - West Texas (Joe Battle Dr) | El Paso | Texas | 79938 | — |
| Texas Oncology - Flower Mound - Carrollton | Flower Mound | Texas | 75028 | — |
| Texas Oncology - Fort Worth Cancer Center | Fort Worth | Texas | 76104 | — |
| Texas Oncology-Grapevine | Grapevine | Texas | 76051 | — |
| Valley Cancer Associates | Harlingen | Texas | 78550 | — |
| Texas Oncology - Memorial City | Houston | Texas | 77024 | — |
| Oncology Consultants | Houston | Texas | 77030 | — |
| Texas Oncology Gulf Coast (Willowbrook) | Houston | Texas | 77070 | — |
| Texas Oncology - Longview Cancer Center | Longview | Texas | 75601 | — |
| Texas Oncology - West Texas (Odessa) | Odessa | Texas | 79761 | — |
| Texas Oncology - Palestine | Palestine | Texas | 75801 | — |
| Texas Oncology - Paris | Paris | Texas | 75460 | — |
| Texas Oncology - Plano East | Plano | Texas | 75075 | — |
| Texas Oncology - Tyler | Tyler | Texas | 75702 | — |
| Texas Oncology - Waco | Waco | Texas | 76712 | — |
| Texas Oncology Golf Coast - Deke Slayton Cancer Center | Webster | Texas | 77598 | — |
| Virginia Cancer Specialists, PC (Kenmore Ave) | Alexandria | Virginia | 22304 | — |
| Virginia Cancer Specialists, PC (N George Mason Dr) | Arlington | Virginia | 22205 | — |
| Virginia Cancer Specialists, PC | Fairfax | Virginia | 22031 | — |
| Virginia Cancer Specialists, PC (Lake Manassas Dr) | Gainesville | Virginia | 20155 | — |
| Virginia Cancer Specialists, PC (Riverside Pkwy) | Leesburg | Virginia | 20176 | — |
| Providence Regional Cancer Partnership | Everett | Washington | 98201 | — |
| MultiCare Regional Cancer Center | Spokane | Washington | 99204 | — |
| West Virginia University Cancer Institute | Morgantown | West Virginia | 26506 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 13 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT04622007, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Apr 29, 2024 · Synced Jul 22, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete protocol, eligibility criteria, and contact information for NCT04622007 live on ClinicalTrials.gov.