Efficacy and Safety of Elpipodect (MK-8189) in Participants With an Acute Episode of Schizophrenia (MK-8189-008)
Public ClinicalTrials.gov record NCT04624243. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase 2B Randomized, Double-Blind, Placebo- and Active-Controlled Trial of the Efficacy and Safety of MK-8189 in Participants Experiencing an Acute Episode of Schizophrenia
Study identification
- NCT ID
- NCT04624243
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 2
- Lead sponsor
- Merck Sharp & Dohme LLC
- Industry
- Enrollment
- 499 participants
Conditions and interventions
Conditions
Interventions
- Elpipodect Drug
- Placebo to MK-8189 Drug
- Placebo to risperidone Drug
- Risperidone Drug
Drug
Eligibility (public fields only)
- Age range
- 18 Years to 55 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Dec 14, 2020
- Primary completion
- Jun 20, 2024
- Completion
- Jun 20, 2024
- Last update posted
- Apr 28, 2026
2020 – 2024
United States locations
- U.S. sites
- 35
- U.S. states
- 15
- U.S. cities
- 30
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Pillar Clinical Research ( Site 1047) | Bentonville | Arkansas | 72712-3873 | — |
| Woodland International Research Group, LLC ( Site 1002) | Little Rock | Arkansas | 72211 | — |
| Woodland Research Northwest, LLC ( Site 1036) | Rogers | Arkansas | 72758 | — |
| CITRIALS ( Site 1010) | Bellflower | California | 90706 | — |
| ProScience Research Group ( Site 1046) | Culver City | California | 90230 | — |
| Collaborative Neuroscience Research, LLC ( Site 1041) | Garden Grove | California | 92845 | — |
| Behavioral Research Specialists, LLC ( Site 1032) | Glendale | California | 91206 | — |
| CITRIALS ( Site 1016) | Riverside | California | 92506 | — |
| Artemis Institute for Clinical Research ( Site 1019) | San Diego | California | 92103 | — |
| California Neuropsychopharmacology Clinical Research Institute, LLC (CNRI-San Diego, LLC) ( Site 103 | San Diego | California | 92123 | — |
| Schuster Medical Research Institute ( Site 1023) | Sherman Oaks | California | 91403 | — |
| Behavioral Clinical Research ( Site 1058) | Hollywood | Florida | 33021 | — |
| Research Centers of America ( Hollywood )-Central Nervous System (CNS) ( Site 1065) | Hollywood | Florida | 33024 | — |
| Premier Clinical Research Institute ( Site 1049) | Miami | Florida | 33122 | — |
| Behavioral Clinical Research , Inc ( Site 1013) | Miami Lakes | Florida | 33016 | — |
| Fort Lauderdale Behavioral Health Center ( Site 1028) | Oakland Park | Florida | 33334 | — |
| Health Synergy Clinical Research ( Site 1051) | Stuart | Florida | 34997 | — |
| Atlanta Center For Medical Research ( Site 1022) | Atlanta | Georgia | 30331 | — |
| CenExel iResearch, LLC ( Site 1039) | Decatur | Georgia | 30030 | — |
| Ascension Saint Elizabeth ( Site 1000) | Chicago | Illinois | 60622 | — |
| Uptown Research Institute ( Site 1052) | Chicago | Illinois | 60640 | — |
| Pillar Clinical Research, LLC ( Site 1038) | Chicago | Illinois | 60641 | — |
| Benchmark Research ( Site 1054) | Shreveport | Louisiana | 71101 | — |
| CBH Health ( Site 1044) | Gaithersburg | Maryland | 20877 | — |
| Massachusetts General Hospital ( Site 1035) | Boston | Massachusetts | 02114 | — |
| Arch Clinical Trials ( Site 1048) | St Louis | Missouri | 63141 | — |
| Altea Research Institute ( Site 1012) | Las Vegas | Nevada | 89102 | — |
| Hassman Research Institute Marlton Site ( Site 1040) | Marlton | New Jersey | 08053 | — |
| Richmond Behavioral Associates ( Site 1064) | Staten Island | New York | 10314 | — |
| New Hope Clinical Research ( Site 1050) | Charlotte | North Carolina | 28211 | — |
| Midwest Clinical Research ( Site 1059) | Dayton | Ohio | 45417 | — |
| Midwest Clinical Research Center ( Site 1033) | Dayton | Ohio | 45417 | — |
| Neuro-Behavioral Clinical Research ( Site 1055) | North Canton | Ohio | 44720 | — |
| Community Clinical Research ( Site 1057) | Austin | Texas | 78754 | — |
| Pillar Clinical Research, LLC ( Site 1004) | Richardson | Texas | 75080 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 86 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT04624243, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Apr 28, 2026 · Synced Apr 29, 2026
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Open the official record
The complete protocol, eligibility criteria, and contact information for NCT04624243 live on ClinicalTrials.gov.