MRCT Evaluating NCX 470 vs. Latanoprost in Subjects With Open-Angle Glaucoma or Ocular Hypertension
Public ClinicalTrials.gov record NCT04630808. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase 3, Randomized, Multi-Regional, Double-Masked, Parallel-Group Trial Evaluating the Safety and Efficacy of NCX 470 0.1% vs. Latanoprost 0.005% in Subjects With Open-Angle Glaucoma or Ocular Hypertension (Denali)
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
The objective of this clinical study is to evaluate the safety and efficacy of NCX 470 Ophthalmic Solution in lowering intraocular pressure (IOP) in subjecs with ocular hypertension or open-angle glaucoma. Subjects will be randomized in a 1:1 ratio to NCX 470 0.1% or to latanoprost 0.005% to be administered to both eyes once daily in the evening for up to 12 months.
Study identification
- NCT ID
- NCT04630808
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 696 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years to 84 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Nov 9, 2020 (Actual)
- Primary completion
- Apr 11, 2025 (Actual)
- Completion
- Jun 25, 2025 (Actual)
- Last update posted
- Sep 8, 2025
2020 – 2025
United States locations
- U.S. sites
- 63
- U.S. states
- 24
- U.S. cities
- 57
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Nicox Clinical Site | Dothan | Alabama | 36301 | — |
| Nicox Clinical Site | Chandler | Arizona | 85224 | — |
| Nicox Clinical Site | Phoenix | Arizona | 85003 | — |
| Nicox Clinical Site | Burbank | California | 91505 | — |
| Nicox Clinical Site | Garden Grove | California | 92843 | — |
| Nicox Clinical Site | Huntington Beach | California | 92647 | — |
| Nicox Clinical Site | La Jolla | California | 92037 | — |
| Nicox Clinical Site | Murrieta | California | 92562 | — |
| Nicox Clinical Site | Newport Beach | California | 92663 | — |
| Nicox Clinical Site | Pasadena | California | 91107 | — |
| Nicox Clinical Site | Petaluma | California | 94954 | — |
| Nicox Clinical Site | Redlands | California | 92373 | — |
| Nicox Clinical Site | San Francisco | California | 94115 | — |
| Nicox Clinical Site | Danbury | Connecticut | 06810 | — |
| Nicox Clinical Site | Boynton Beach | Florida | 33437 | — |
| Nicox Clinical Site | Delray Beach | Florida | 33484 | — |
| Nicox Clinical Site | Fort Lauderdale | Florida | 33309 | — |
| Nicox Clinical Site | Fort Myers | Florida | 33901 | — |
| Nicox Clinical Site | Jacksonville | Florida | 32256 | — |
| Nicox Clinical Site | Jupiter | Florida | 33477 | — |
| Nicox Clinical Site | Lakeland | Florida | 33805 | — |
| Nicox Clinical Site | Largo | Florida | 33770 | — |
| Nicox Clinical Site | Mt. Dora | Florida | 32757 | — |
| Nicox Clinical Site | Venice | Florida | 34285 | — |
| Nicox Clinical Site | Morrow | Georgia | 30260 | — |
| Nicox Clinical Site | Roswell | Georgia | 30076 | — |
| Nicox Clinical Site | Peoria | Illinois | 61615 | — |
| Nicox Clinical Site | Rock Island | Illinois | 61201 | — |
| Nicox Clinical Site | Indianapolis | Indiana | 46202 | — |
| Nicox Clinical Site | Bangor | Maine | 04401 | — |
| Nicox Clinical Site | Boston | Massachusetts | 02114 | — |
| Nicox Clinical Site | Lancaster | Massachusetts | 01523 | — |
| Nicox Clinical Site | Grand Rapids | Michigan | 49546 | — |
| Nicox Clinical Site | Chaska | Minnesota | 55318 | — |
| Nicox Clinical Site | Kansas City | Missouri | 64111 | — |
| Nicox Clinical Site | St Louis | Missouri | 63128 | — |
| Nicox Clinical Site | Clifton Park | New York | 12065 | — |
| Nicox Clinical Site | The Bronx | New York | 10467 | — |
| Nicox Clinical Site | Troy | New York | 12180 | — |
| Nicox Clinical Site | Asheville | North Carolina | 28803 | — |
| Nicox Clinical Site | Winston-Salem | North Carolina | 27101 | — |
| Nicox Clinical Site | Fargo | North Dakota | 58103 | — |
| Nicox Clinical Site | Cincinnati | Ohio | 45236 | — |
| Nicox Clinical Site | Cincinnati | Ohio | 45242 | — |
| Nicox Clinical Site | Eugene | Oregon | 97401 | — |
| Nicox Clinical Site | Cranberry Township | Pennsylvania | 16066 | — |
| Nicox Clinical Site | Kingston | Pennsylvania | 18704 | — |
| Nicox Clinical Site | Memphis | Tennessee | 38119 | — |
| Nicox Clinical Site | Memphis | Tennessee | 38120 | — |
| Nicox Clinical Site | Austin | Texas | 78731 | — |
| Nicox Clinical Site | El Paso | Texas | 79922 | — |
| Nicox Clinical Site | Houston | Texas | 77008 | — |
| Nicox Clinical Site | Houston | Texas | 77025 | — |
| Nicox Clinical Site | Mission | Texas | 78572 | — |
| Nicox Clinical Site | San Antonio | Texas | 78212 | — |
| Nicox Clinical Site | San Antonio | Texas | 78229 | — |
| Nicox Clinical Site | San Antonio | Texas | 78238 | — |
| Nicox Clinical Site | Sugar Land | Texas | 77479 | — |
| Nicox Clinical Site | St. George | Utah | 84790 | — |
| Nicox Clinical Site | Falls Church | Virginia | 22042 | — |
| Nicox Clinical Site | Bellevue | Washington | 98004 | — |
| Nicox Clinical Site | Seattle | Washington | 98104 | — |
| Nicox Clinical Site | Seattle | Washington | 98125 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 25 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT04630808, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Sep 8, 2025 · Synced Oct 20, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT04630808 live on ClinicalTrials.gov.