Efficacy of Amniotic Suspension Allograft in Patients With Osteoarthritis of the Knee
Public ClinicalTrials.gov record NCT04636229. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase 3 Prospective, Multicenter, Double-blind, Randomized, Placebo-controlled Study to Evaluate the Efficacy of Amniotic Suspension Allograft (ASA) in Patients With Osteoarthritis of the Knee
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
This study is being conducted to evaluate the efficacy and safety of ASA compared to placebo in the management of osteoarthritis (OA) symptoms of the knee.
Study identification
- NCT ID
- NCT04636229
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 516 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Dec 14, 2020 (Actual)
- Primary completion
- Jul 30, 2023 (Actual)
- Completion
- Aug 19, 2025 (Actual)
- Last update posted
- Oct 16, 2025
2020 – 2025
United States locations
- U.S. sites
- 38
- U.S. states
- 17
- U.S. cities
- 33
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Central Research Associates | Birmingham | Alabama | 35205 | — |
| Alabama Clinical Therapeutics | Birmingham | Alabama | 35235 | — |
| AMR Mobile | Mobile | Alabama | 36608 | — |
| Arizona Arthritis & Rheumatology Research | Glendale | Arizona | 85306 | — |
| Fiel Family & Sports Medicine/ CCT Research | Tempe | Arizona | 85283 | — |
| Arizona Arthritis & Rheumatology Research | Tucson | Arizona | 85704 | — |
| Tri West Research Associates | El Cajon | California | 92020 | — |
| Horizon Clinical Research Center | La Mesa | California | 91942 | — |
| Actca, A Member of the Allliance Inc. | Los Angeles | California | 90036 | — |
| University of California at Los Angeles | Los Angeles | California | 90095 | — |
| Stanford Medicine | Redwood City | California | 94063 | — |
| University of California at Davis | Sacramento | California | 95186 | — |
| AARDS Research, Inc. | Aventura | Florida | 33180 | — |
| Gulfcoast Research Institute | Sarasota | Florida | 34232 | — |
| Pinnacle Trials, Inc. | Stockbridge | Georgia | 30281 | — |
| Injury Care Research | Boise | Idaho | 83713 | — |
| Chicago Clinical Research Institute Inc | Chicago | Illinois | 60607 | — |
| Rush University Medical Center | Chicago | Illinois | 60612 | — |
| Affinity Health | Oak Brook | Illinois | 60523 | — |
| Sinai Hospital of Baltimore | Baltimore | Maryland | 21215 | — |
| Klein & Associates, MD, PA | Hagerstown | Maryland | 21740 | — |
| Tufts Medical Center | Boston | Massachusetts | 02111 | — |
| Methodist Physicians Clinic/ CCT Researc | Fremont | Nebraska | 68025 | — |
| Physician Research Collaboration | Lincoln | Nebraska | 68516 | — |
| NYU Langone Health | New York | New York | 10016 | — |
| Hospital for Special Surgery | New York | New York | 10021 | — |
| Lenox Hill Hospital (Northwell Health) | New York | New York | 10075 | — |
| M3 Emerging Medical Research, LLC | Durham | North Carolina | 27704 | — |
| Moore Orthopedics and Sports Medicine | Morehead City | North Carolina | 28557 | — |
| M3 Emerging Medical Research, LLC | Raleigh | North Carolina | 27612 | — |
| Lehigh Center for Clinical Research | Allentown | Pennsylvania | 18104 | — |
| University Orthopedics Center | Altoona | Pennsylvania | 16602 | — |
| University Orthopedic Center | State College | Pennsylvania | 16801 | — |
| PCPMG Clinical Research Unit, LLC | Greenville | South Carolina | 29501 | — |
| Coastal Carolina Research Center | North Charleston | South Carolina | 29406 | — |
| Affinity Health | Nashville | Tennessee | 37203 | — |
| Cedar Health Research, LLC | Burleson | Texas | 76028 | — |
| Spectrum Medical, Inc | Danville | Virginia | 24541 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT04636229, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Oct 16, 2025 · Synced Oct 23, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT04636229 live on ClinicalTrials.gov.