Adaptive COVID-19 Treatment Trial 4 (ACTT-4)
Public ClinicalTrials.gov record NCT04640168. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Multicenter, Adaptive, Randomized Blinded Controlled Trial of the Safety and Efficacy of Investigational Therapeutics for the Treatment of COVID-19 in Hospitalized Adults (ACTT-4)
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
ACTT-4 will evaluate the combination of baricitinib and remdesivir compared to dexamethasone and remdesivir. Subjects will be assessed daily while hospitalized. If the subjects are discharged from the hospital, they will have a study visit at Days 15, 22, and 29. For discharged subjects, it is preferred that the Day 15 and 29 visits are in person to obtain safety laboratory tests, oropharyngeal (OP) swabs, plasma (Day 29), and serum for secondary research as well as clinical outcome data. However, if infection control or other restrictions limit the ability of the subject to return to the clinic, these visits may be conducted by phone, and only clinical data will be obtained. The Day 22 visit does not have laboratory tests or collection of samples and is conducted by phone. The primary objective is to evaluate the clinical efficacy of baricitinib + remdesivir versus dexamethasone + remdesivir as assessed by the mechanical ventilation free survival by Day 29.
Study identification
- NCT ID
- NCT04640168
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 1,010 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years to 99 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Dec 2, 2020 (Actual)
- Primary completion
- May 18, 2021 (Actual)
- Completion
- Jun 18, 2021 (Actual)
- Last update posted
- Jun 28, 2022
2020 – 2021
United States locations
- U.S. sites
- 61
- U.S. states
- 27
- U.S. cities
- 53
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| University of Alabama at Birmingham School of Medicine - Infectious Disease | Birmingham | Alabama | 35233 | — |
| UCSF Fresno Center for Medical Education and Research - Clinical Research Center | Fresno | California | 93701 | — |
| University of California San Diego Health - Jacobs Medical Center | La Jolla | California | 29037 | — |
| University of California Los Angeles Medical Center - Westwood Clinic | Los Angeles | California | 90095 | — |
| University of California Irvine Medical Center - Infectious Disease | Orange | California | 92868-3298 | — |
| VA Palo Alto Health Care System - Infectious Diseases | Palo Alto | California | 94304-1207 | — |
| University of California Davis Medical Center - Internal Medicine - Infectious Disease | Sacramento | California | 95817-1460 | — |
| Kaiser Permanente San Diego Medical Center | San Diego | California | 92123 | — |
| Naval Medical Center San Diego - Infectious Disease Clinic | San Diego | California | 92314 | — |
| University of California San Francisco - Zuckerberg San Francisco General Hospital - Division of Human Immunodeficiency Virus, Infectious Disease, and Global Medicine | San Francisco | California | 94110-2859 | — |
| Stanford University - Stanford Hospital and Clinics - Pediatrics - Infectious Diseases | Stanford | California | 94305-2200 | — |
| Cedars Sinai Medical Center | West Hollywood | California | 90048-1804 | — |
| VA Eastern Colorado Health Care System | Aurora | Colorado | 80045 | — |
| Denver Health Division of Hospital Medicine - Main Campus | Denver | Colorado | 80204 | — |
| Georgetown University Medical Center - Division of Infectious Diseases | Washington D.C. | District of Columbia | 20007 | — |
| University of Florida Health - Shands Hospital - Division of Infectious Diseases and Global Medicine | Gainesville | Florida | 32610 | — |
| University of Florida Health - Jacksonville - Department of Emergency Medicine | Jacksonville | Florida | 32209 | — |
| University of Miami Miller School of Medicine - Infectious Diseases | Miami | Florida | 33136 | — |
| Emory Vaccine Center - The Hope Clinic | Decatur | Georgia | 30030-1705 | — |
| Atlanta VA Medical Center - Infectious Diseases Clinic | Decatur | Georgia | 30033 | — |
| Tripler Army Medical Center | Honolulu | Hawaii | 96859 | — |
| Northwestern Hospital - Infectious Disease | Chicago | Illinois | 60611-2908 | — |
| University of Illinois at Chicago College of Medicine - Division of Infectious Diseases | Chicago | Illinois | 60612 | — |
| University of Iowa Hospitals & Clinics - Department of Internal Medicine | Iowa City | Iowa | 52242 | — |
| Tulane University - Section of Pulmonary Diseases, Critical Care, and Environmental Medicine | New Orleans | Louisiana | 70112 | — |
| University of Maryland School of Medicine - Center for Vaccine Development - Baltimore | Baltimore | Maryland | 21201-1509 | — |
| Johns Hopkins Hospital - Medicine - Infectious Diseases | Baltimore | Maryland | 21287-0005 | — |
| Walter Reed National Military Medical Center | Bethesda | Maryland | 20889 | — |
| National Institutes of Health - Clinical Center, National Institute of Allergy and Infectious Diseases Laboratory Of Immunoregulation, Clinical Research Section | Bethesda | Maryland | 20892-1504 | — |
| Massachusetts General Hospital - Infectious Diseases | Boston | Massachusetts | 02114-2621 | — |
| University of Massachusetts Medical School - Infectious Diseases and Immunology | Worcester | Massachusetts | 01655-0002 | — |
| University of Michigan - Infectious Disease Clinic at Taubman Center | Ann Arbor | Michigan | 48109 | — |
| University of Minnesota Medical Center, Fairview - Infectious Diseases and International Medicine | Minneapolis | Minnesota | 55455-0341 | — |
| Saint Louis University - Center for Vaccine Development | St Louis | Missouri | 63104-1015 | — |
| University of Nebraska Medical Center - Infectious Diseases | Omaha | Nebraska | 68105 | — |
| CHI Health Creighton University Medical Center - Bergan Mercy - Pulmonary Medicine | Omaha | Nebraska | 68124 | — |
| Atlantic Health System - Morristown Medical Center | Morristown | New Jersey | 07960 | — |
| University of New Mexico Clinical and Translational Science Center | Albuquerque | New Mexico | 87106 | — |
| New York University School of Medicine - Langone Medical Center - Microbiology - Parasitology | New York | New York | 10016-6402 | — |
| University of Rochester Medical Center - Vaccine Research Unit | Rochester | New York | 14642-0001 | — |
| Montefiore Medical Center - Infectious Diseases | The Bronx | New York | 10467-2401 | — |
| Duke Human Vaccine Institute - Duke Vaccine and Trials Unit | Durham | North Carolina | 27704 | — |
| Womack Army Medical Center - Pulmonary and Respiratory Services | Fort Bragg | North Carolina | 28310 | — |
| University of Oklahoma Health Science Center - Surgery | Oklahoma City | Oklahoma | 73104 | — |
| Kaiser Permanente Northwest - Center for Health Research | Portland | Oregon | 97227 | — |
| Penn State Health Milton S. Hershey Medical Center - Division of Infectious Diseases | Hershey | Pennsylvania | 17033 | — |
| Hospital of the University of Pennsylvania - Infectious Diseases | Philadelphia | Pennsylvania | 19104-4238 | — |
| University of Pittsburgh - Medicine - Infectious Diseases | Pittsburgh | Pennsylvania | 15213-2582 | — |
| Baylor Scott & White Health - Baylor University Medical Center - North Texas Infectious Disease Consultants | Dallas | Texas | 75246 | — |
| University of Texas Southwestern Medical Center - Internal Medicine - Infectious Diseases | Dallas | Texas | 75390-8884 | — |
| Brooke Army Medical Center | Fort Sam Houston | Texas | 78234 | — |
| University of Texas Medical Branch - Division of Infectious Disease | Galveston | Texas | 77555-0435 | — |
| Methodist Hospital - Houston | Houston | Texas | 77030-2703 | — |
| Baylor College of Medicine - Molecular Virology and Microbiology | Houston | Texas | 77030-3411 | — |
| University of Texas Health Science Center at San Antonio - Infectious Diseases | San Antonio | Texas | 78229-3901 | — |
| University of Utah - Infectious Diseases | Salt Lake City | Utah | 84132-0002 | — |
| University of Virginia - Acute Care Surgery | Charlottesville | Virginia | 22908-0816 | — |
| Naval Medical Center Portsmouth - Infectious Disease Division | Portsmouth | Virginia | 23708 | — |
| EvergreenHealth Infectious Disease Service | Kirkland | Washington | 98034 | — |
| Providence Sacred Heart Medical Center | Spokane | Washington | 99204 | — |
| Madigan Army Medical Center - Infectious Disease Clinic | Tacoma | Washington | 98431 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 11 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT04640168, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Jun 28, 2022 · Synced Oct 17, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT04640168 live on ClinicalTrials.gov.